Postacne Scarring: A Review of its Pathophysiology and Treatment

Goodman, Greg

doi:10.1046/j.1524-4725.2000.99232.x

Cited by 123 publications

(96 citation statements)

References 103 publications

(102 reference statements)

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“…In addition, tissues are also destroyed by enzymatic activities and by the actions of inflammatory mediators released from disrupted acne follicles and cysts. 32 Although laser skin resurfacing has revolutionized the treatment of atrophic acne scars, they still present a major therapeutic challenge. Ablative laser resurfacing using CO 2 or Er:YAG lasers has an efficacy of 25% to 90% for treating acne scars 14 and is considered the ''gold'' standard.…”

Section: Discussionmentioning

confidence: 99%

Comparison of a 585-nm pulsed dye laser and a 1064-nm Nd:YAG laser for the treatment of acne scars: A randomized split-face clinical study

Lee

Choi

Min

et al. 2009

Journal of the American Academy of Dermatology

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Section: Discussionmentioning

confidence: 99%

Comparison of a 585-nm pulsed dye laser and a 1064-nm Nd:YAG laser for the treatment of acne scars: A randomized split-face clinical study

Lee

Choi

Min

et al. 2009

Journal of the American Academy of Dermatology

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“…1,2 For atrophic scars, chemical peels, excisional surgery, punch grafting, and dermabrasion have been performed with limited success because of potential side effects and the need for multiple treatments. 3 This article discusses novel and future techniques in the treatment of abnormal scarring (Table I) …”

mentioning

confidence: 99%

Novel Opportunities in the Treatment and Prevention of Scarring

2004

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Numerous treatments have been described for the treatment and prevention of scars, but the optimal management strategy is yet to be defined. In this article we present and evaluate new opportunities for the treatment and prevention of hypertrophic scars, keloids, and atrophic scars. Clinical, animal, and in vitro studies reporting novel techniques for the treatment and prevention of scarring were identified primarily from the MEDLINE/PubMed database. We found that a variety of new treatments exist with potential effectiveness for the treatment of hypertrophic scars and keloids, including interferon, imiquimod 5% cream, tacrolimus, botulinum toxin, 5-fluorouracil, bleomycin, and verapamil. For atrophic scars, different types of lasers represent modern treatment modalities with satisfactory results. Several agents have been reported to be effective in reducing scarring in vitro and in animal studies, representing potential opportunities for scarring management. We conclude that several novel modalities may be potential therapies for scarring.

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“…Several modalities have been advocated to treat acne scarring, including surgical techniques (punch grafts, punch excisions, subcision), resurfacing techniques (dermabrasion, ablative laser treatment, chemical peels), non-ablative laser treatment, autologous fat transfer, and injection of dermal fillers [1,2]. A combination of different modalities is typically required to achieve satisfactory results, and each technique carries different risks and side effects.…”

Section: Introductionmentioning

confidence: 99%

Treatment of acne scars using the plasma skin regeneration (PSR) system

et al. 2008

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Background and Objectives: Acne scarring is a common and difficult to treat condition. The plasma skin regeneration (PSR) system is a novel device that causes delayed ablation of the epidermis and controlled thermal modification to the underlying dermis. PSR has previously been shown to be a safe and effective treatment for facial rhytides and benign skin lesions. In this study, we investigated the safety and efficacy of single-treatment, highenergy, double-pass PSR for the treatment of acne scarring. Study Design/Materials and Methods: Ten patients with acne scarring and Fitzpatrick skin types I-III were included in the study. All patients underwent a single PSR treatment with two high-energy passes (3.5-4.0 J). Treatments were performed in an outpatient clinic setting. Nine patients completed 6 months of follow-up. Improvement was determined by patient questionnaires and physician evaluation of digital photographs taken prior to treatment and at 3 and 6 months post-treatment. Results: On average, patients reported 34% improvement in their acne scarring at 3 months and 33% improvement at 6 months. Blinded physician ratings of patient photos demonstrated 19% improvement at 3 months and 34% at 6 months. Re-epithelialization was complete by 4-6 days after treatment, and no serious adverse events were encountered. Conclusion: PSR appears to provide a safe and effective single treatment, minimal downtime alternative for the treatment of acne scarring. Additional studies are warranted to further demonstrate the safety and efficacy of this device.

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Postacne Scarring: A Review of its Pathophysiology and Treatment

Abstract: Atrophic postacne scars may be satisfactorily treated in many patients, but multiple methods are often required to ensure the best results.

Cited by 123 publications

References 103 publications

Comparison of a 585-nm pulsed dye laser and a 1064-nm Nd:YAG laser for the treatment of acne scars: A randomized split-face clinical study

Comparison of a 585-nm pulsed dye laser and a 1064-nm Nd:YAG laser for the treatment of acne scars: A randomized split-face clinical study

Novel Opportunities in the Treatment and Prevention of Scarring

Treatment of acne scars using the plasma skin regeneration (PSR) system

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