Post-yield and failure properties of cortical bone

Wolfram, Uwe; Schwiedrzik, Jakob

doi:10.1038/bonekey.2016.60

Cited by 69 publications

(46 citation statements)

References 132 publications

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“…To quantify the regions of high stress and the risk of loosening of different screws, the bone with the equivalent stress above 55 MPa around each screw was selected and their volume was calculated. This value is used according to the research result on yield stress of the tibia cortical bone in young patients . The value of 55 MPa equivalent stress is intended to be an indicator of regions of relatively high stress and consequent loosening.…”

Section: Methodsmentioning

confidence: 99%

Bone resorption triggered by high radial stress: The mechanism of screw loosening in plate fixation of long bone fractures

Feng

Lin

Fang

et al. 2019

Journal Orthopaedic Research

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Screw loosening is a common complication in plate fixation. However, the underlying mechanism is unclear. This study investigated screw loosening mechanisms by finite element analysis (FEA) simulation and clinical X‐ray feature analysis. Two FEA models incorporated bone heterogeneity and orthotropy, representing fracture fixation using dynamic compression plate (DCP) and locking compression plate (LCP), were developed. These models were used to examine the volume of bone exceeding a certain stress value around each screw under physiologically‐relevant loading conditions. These damaged bone was then separated and compared by the axial stress and radial stress of each screw. In addition, features of patients’ X‐ray images showing screw loosening were analyzed to validate the loosening features simulated by the models. The FEA study showed that more damaged bone was found at the central two screws which gradually decreased toward the two end screws in all groups. More bone was damaged by the radial stress of each screw than by the axial stress. The radiological analysis of screw loosening showed that bone loss occurred at the screw closest to the fracture line first then subsequent bone loss at the screws further away from the fracture line occurred. This study found that the two screws nearest to the fracture line are more vulnerable to loosening. The radial stress of the screw plays a larger role in screw loosening than the axial stress. Bone resorption triggered by the high radial stress of screws is indicated as the mechanism of screw loosening in the diaphyseal plate fixation. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:1498–1507, 2019.

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Section: Methodsmentioning

confidence: 99%

Bone resorption triggered by high radial stress: The mechanism of screw loosening in plate fixation of long bone fractures

Feng

Lin

Fang

et al. 2019

Journal Orthopaedic Research

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“…Overall, the enhanced morphometric parameters for the HI and MI groups during the normal cage activity period and at adulthood support the consequently improved mechanical properties. PYD, which is a measure of ductility, and PYE significantly increased in the HI group compared with the sham group. The greater PYD can be correlated to the higher stiffness and failure strength observed in the HI group .…”

Section: Discussionmentioning

confidence: 88%

Isolated Cyclic Loading During Adolescence Improves Tibial Bone Microstructure and Strength at Adulthood

et al. 2020

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Bone is a unique living tissue, which responds to the mechanical stimuli regularly imposed on it. Adolescence facilitates a favorable condition for the skeleton that enables the exercise to positively influence bone architecture and overall strength. However, it is still dubious for how long the skeletal benefits gained in adolescence is preserved at adulthood. The current study aims to use a rat model to investigate the effects of in vivo low‐ (LI), medium‐ (MI), and high‐ (HI) intensity cyclic loadings applied during puberty on longitudinal bone development, morphometry, and biomechanics during adolescence as well as at adulthood. Forty‐two young (4‐week‐old) male rats were randomized into control, sham, LI, MI, and HI groups. After a 5 day/week for 8 weeks cyclic loading regime applied on the right tibia, loaded rats underwent a subsequent 41‐week, normal cage activity period. Right tibias were removed at 52 weeks of age, and a comprehensive assessment was performed using μCT, mechanical testing, and finite element analysis. HI and MI groups exhibited reduced body weight and food intake at the end of the loading period compared with shams, but these effects disappeared afterward. HI cyclic loading increased BMD, bone volume fraction, trabecular thickness, trabecular number, and decreased trabecular spacing after loading. All loading‐induced benefits, except BMD, persisted until the end of the normal cage activity period. Moreover, HI loading induced enhanced bone area, periosteal perimeter, and moment of inertia, which remained up to the 52nd week. After the normal cage activity at adulthood, the HI group showed increased ultimate force and stress, stiffness, postyield displacement and energy, and toughness compared with the sham group. Overall, our findings suggest that even though both trabecular and cortical bone drifted through age‐related changes during aging, HI cyclic loading performed during adolescence can render lifelong benefits in bone microstructure and biomechanics. © 2020 The Authors. JBMR Plus published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research.

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“…Cortical and trabecular bones were supposed to obey isotropic and kinematic hardening respectively, as it was demonstrated by previous studies: Garcia (2006) and Wolfram and Jakob (2016) for cortical, Keaveny et al (1999) and Li et al (2010) for trabecular.…”

Section: Constitutive Lawmentioning

confidence: 87%

On dynamic behavior of bone: Experimental and numerical study of porcine ribs subjected to impact loads in dynamic three-point bending tests

Ayagara

Langlet

Hambli

2019

Journal of the Mechanical Behavior of Biomedical Materials

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This study covers the characterization of the dynamic behavior of isolated porcine ribs based on experimental and numerical approaches. A Split Hopkinson Pressure Bar (SHPB) setup for three-point bending tests was used. Data of 20 tests were considered to be comprehensible for experimental characterization, thereby, showing an influence of strain rate on both time for fracture and amplitudes of force response. A three-dimensional porcine rib model was generated from the DICOM (Digital Imaging and Communication in Medicine) images of High-Resolution peripheral Quantitative Computed Tomography (HR-pQCT) scans. Material properties having been fitted by power law regression equations based on apparent density were assigned to the numerical rib. A modified elastic-plastic constitutive law, capable of considering the effects of strain rate was adopted. An incremental and stress-state dependent damage law, capable of considering effects of strain rate on fracture propagation, non-linear damage accumulation and instabilities was coupled to the constitutive law. The Finite Element (FE) model shows high efficiency in predicting both force-displacement curve and the fracture patterns of tested ribs. Predictions prove the ability of the proposed model to investigate the fracture behavior of human ribs under dynamic loads.

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Post-yield and failure properties of cortical bone

Cited by 69 publications

References 132 publications

Bone resorption triggered by high radial stress: The mechanism of screw loosening in plate fixation of long bone fractures

Bone resorption triggered by high radial stress: The mechanism of screw loosening in plate fixation of long bone fractures

Isolated Cyclic Loading During Adolescence Improves Tibial Bone Microstructure and Strength at Adulthood

On dynamic behavior of bone: Experimental and numerical study of porcine ribs subjected to impact loads in dynamic three-point bending tests

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