Post Vaccination Optic Neuritis: Observations From the SARS-CoV-2 Pandemic

Alvarez, Lidia Martinez; Neo, Yan Ning; Davagnanam, Indran; Ashenhurst, Michael; Acheson, James; Abdel-Hay, Ahmed; Alshowaeir, Daniah; Bakheet, Mashair; Balaguer, Óscar; Batra, Ruchika; Braithwaite, Tasanee; Bremner, Fion; Britton, Zelie; Brownlee, Wallace; Burke, Ailbhe; Carreras, Anna; Costello, Fiona; Coulette, Sarah; Ramirez, Nieves De Las Rivas; Deschamps, Romain; Fraser, Clare; Galleguillos, Lorna; Ortiz, Hector Fernandez Jimenez; Flores-Rivera, José; Tilikete, Caroline; Guajardo, J.; Khaleeli, Zhaleh; Lardeux, Pierre; Lagrou, Lisa; Martin, Ruth Elwood; Meira, Dália; Miszkiel, Katherine; Muñoz, Silvia; Nowak, Victoria; Ogunbowale, Lola; O’Sullivan, Eoin D.; Paul, Friedemann; Rodríguez‐Morales, Alfonso J.; Dalmau, Bernardo Sánchez; Sadun, Federico; Síva, Aksel; Spörri, Muriel; Stangel, Martin; Trip, Anand; Toosy, Ahmed; Tütüncü, Melih; Wattjes, Mike P.; Woolmore, John; Wong, Sui; Zvorničanin, Jasmin; Cruz, Franz Marie; Petzold, Axel

doi:10.2139/ssrn.3889990

Cited by 11 publications

(17 citation statements)

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“…Although MOG-IgG was not tested in these cases, these clinical presentations are highly characteristic of MOG antibody disease (57–63). Therefore, it is possible that similarly to the described cases of ON presenting after the COVID vaccination (22,23), at least some can retrospectively be attributed to MOG-IgG.…”

Section: Discussionmentioning

confidence: 90%

“…A total of 14 case reports and 2 case series have been selected for inclusion in the final report. Overall, 76 cases of post-COVID-vaccination adverse events have been reported, including ON (n = 61) (22)(23)(24)(25), optic disc edema as atypical presentation of Guillain-Barre syndrome (n = 1…”

Section: Resultsmentioning

confidence: 99%

“…PLEX was administered in 6 cases (not reported whether in conjunction with steroids or as a sole treatment). The visual outcome was overall good (median logMAR 0.0), but poor for some individuals (MAX logMAR 3.0; the number of cases not reported) (22).…”

Section: Resultsmentioning

confidence: 99%

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Neuro-Ophthalmological Complications of the COVID-19 Vaccines: A Systematic Review

Lotan¹,

Lydston²,

Lévy³

2022

Journal of Neuro-Ophthalmology

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Section: Discussionmentioning

confidence: 90%

Section: Resultsmentioning

confidence: 99%

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Neuro-Ophthalmological Complications of the COVID-19 Vaccines: A Systematic Review

Lotan¹,

Lydston²,

Lévy³

2022

Journal of Neuro-Ophthalmology

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“…In our experience, recovery of high contrast visual acuities in post-SARS-CoV-2 vaccination is good with a group average of logMAR 0.0. 35 Inner retinal layer atrophy can be substantial despite the good functional outcome as illustrated in Figure 4. Interestingly, a proportion of individuals with postvaccination ON were myelin oligodendrocyte glycoprotein seropositive.…”

Section: Cranial Nervementioning

confidence: 99%

“…It may take several years for databases to have fully maturated to answer the following 4 questions inspired by our own observations. 35 First, the worry at onset of the pandemic was that the incidence of many conditions triggered by infection may increase. The early impression on one such condition, postinfectious ON, does not give a signal in that direction.…”

Section: Pupil Abnormalitiesmentioning

confidence: 99%

Neuro-Ophthalmic Implications of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Related Infection and Vaccination

Petzold

2022

Asia-Pacific Journal of Ophthalmology

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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic created a unique opportunity to study the effects of infection and vaccination on disease. The year 2020 was dominated by infection and its consequences. The year 2021 was dominated by vaccination and its consequences. It will still take several years for full maturation of databases required for robust epidemiological studies. Therefore, this review on the implications for neuro-ophthalmology draws on resources presently available including reported adverse reactions to vaccination. Illustrative clinical cases are presented. The spectrum of pathology following infection with SARS-CoV-2 falls into 4 main categories: autoimmune, vascular, sequelae of brain damage, and miscellaneous. This review is exhaustive, but the most common conditions discussed relate to headaches and associated symptoms; vertigo, diplopia, and nystagmus; vascular complications of the eye and brain; cranial nerve (mono-)neuropathies; photophobia, ocular discomfort, and optic neuritis. Of the 36 main adverse reactions reviewed, vaccine-induced immune thrombotic thrombocytopenia is a novel complication requiring specific hematological management. Updated diagnostic criteria are summarized. It is relevant to remember taking a medication history because of side effects and to recognize the relevance of comorbidities. The clinical assessment can frequently be performed virtually. Consensus recommendations on telemedicine and the virtual assessment are summarized in a practical and compressed format. The review concludes with an epidemiological tetralogy to interrogate, in future studies, associations with (1) SARS-CoV-2 pandemic infection, (2) SARS-CoV-2 worldwide vaccination, and (3) the possibility of a rebound effect of infections in the pandemic aftermath.

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Eye Complications Following COVID-19

Saxena

Dhiman

2022

Post COVID-19 Complications and Management

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Post Vaccination Optic Neuritis: Observations From the SARS-CoV-2 Pandemic

Cited by 11 publications

References 0 publications

Neuro-Ophthalmological Complications of the COVID-19 Vaccines: A Systematic Review

Neuro-Ophthalmological Complications of the COVID-19 Vaccines: A Systematic Review

Neuro-Ophthalmic Implications of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Related Infection and Vaccination

Eye Complications Following COVID-19

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