Post-tubal sterilization problems correlated with ovarian steroidogenesis

Cattanach, John F.; Milne, Barrie J.

doi:10.1016/0010-7824(88)90157-6

Cited by 52 publications

(26 citation statements)

References 10 publications

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“…This includes clinical reports showing that menstrual disorders (Neil et al, 1975;Sorenson and Ladehoff, 1979;DeStefano et al, 1985) and alterations in oestrogen and progesterone levels (Cattanach and Milne, 1988;Helm amd Sjoberg, 1983;Hakverdi et al, 1994) have been seen following tubal ligations. Future studies involving prospective designs may be most useful, given the potential in case-control studies, such as ours, for difficulties in recall.…”

Section: Discussionmentioning

confidence: 99%

True

et al. 2000

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SummaryAlthough it has been demonstrated in previous studies that tubal ligation can have widespread effects on ovarian function, including a decrease in the risk of subsequent ovarian cancer, few studies have evaluated effects on breast cancer risk. In a population-based case-control study of breast cancer among women 20-54 years of age conducted in three geographic areas, previous tubal ligations were reported by 25.3% of the 2173 cases and 25.8% of the 1990 controls. Initially it appeared that tubal ligations might impart a slight reduction in risk, particularly among women undergoing the procedure at young ages (< 25 years). However, women were more likely to have had the procedure if they were black, less educated, young when they bore their first child, or multiparous. After accounting for these factors, tubal ligations were unrelated to breast cancer risk (relative risk (RR) = 1.09, 95% confidence interval (CI) 0.9-1.3), with no variation in risk by age at, interval since, or calendar year of the procedure. Subjects were asked to complete a month-by-month calendar documenting all contraceptive methods used since menarche. Pregnancies and other life events were first marked on the calendar to serve as a frame of reference for changes in contraceptive behaviour over time. Information recorded on the calendar regarding the occurrence of a tubal ligation was used to compute the age at, interval since, and calendar time of the procedure.Completed interviews were obtained from 2202 of the 2558 eligible cases (86.1%) and 2009 of the 2477 eligible controls (81.1%). Reasons for non-interview included subject refusals (6.4% in cases vs 14.0% in controls), death (0.4% vs 0.2%), illness (0.6% vs 0.2%), language problems (0.3% vs 1.4%), a move outside of the study area (0.6% vs 2.3%) and other miscellaneous reasons (0.2% vs 0.8%). In addition, physician consent for interview was denied for 5.4% of the cases. Among controls, an overall response rate of 73.4% was achieved through multiplication of the telephone screener and interview response rates. To assure comparability between the cases and controls, the 29 cases who indicated on interview that they did not have a residential telephone and the 19 controls with a history of breast cancer were eliminated, leaving 2173 cases and 1990 controls available for analysis.Since the median interval between diagnosis and interview was 87 days for cases, all information on risk factors, including that pertaining to tubal ligations, was truncated at the date of diagnosis for cases or the date at completion of the telephone screener for controls. The relationship of breast cancer risk factors to tubal ligation among the controls was assessed by calculating χ 2 statistics. The relationship of tubal ligation to breast cancer risk was assessed through calculation of odds ratios to approximate relative risks (RRs). Logistic regression analyses were used to obtain maximum likelihood estimates of RRs and their 95% confidence intervals (CI) (Breslow and Day, 1980). The significance of in...

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Section: Discussionmentioning

confidence: 99%

True

et al. 2000

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“…There studies, it was reported that the decreasing ovarian function was associated with disturbed utero-ovarian blood flow/ hypoxia subsequent to the surgical procedure (3,(9)(10)(11). In contrast to these studies, it has also been reported that tubal sterilization and/or the method of sterilization per se had no effect on ovarian function.…”

Section: Discussionmentioning

confidence: 99%

The comparison of the degree of apoptosis in ovaries and fallopian tubes between two different surgical interventions for tubal ligation: a rat-model

Mümüşoğlu¹,

Hacıvelioğlu²,

Karakoc-Sokmensuer³

et al. 2017

J Turkish German Gynecol Assoc

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Objective:To compare the degree of apoptosis in ovaries and tubal epithelium observed secondary to tubal ligation either by Pomeroy's method or bipolar electrocauterization in a rat model. Material and Methods:A total of 24 female Sprague-Dawley rats were randomly assigned into 3 study groups: control (n=8), Pomeroy (n=8), and the electrocauterization group (n=8). Apoptotic cells were detected on the primary, secondary, tertiary follicles of the ovaries, and on the tubal epithelium using terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end-labeling. The apoptotic index was calculated for each group by the percentage of the stained cells.

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“…4 In 1987, Riedel HH et al 5 found that the levels of estrogen and progesterone decrease after fallopian tube sterilization and hysterectomy.…”

Section: Introductionmentioning

confidence: 99%

“…The alteration of the ovarian function by sterilization has been hypothesized to be responsible for menstrual abnormalities and hormonal disturbances that characterize the so-called posttubal ligation syndrome. 3,4 The logic behind this theory is that the vascularization of the ovaries by either ovarian artery or the uteroovarian anastomoses as well as the fallopian tube destruction reduce the utero-ovarian arterial blood flow in the mesosalpinx, which leads to ovarian tissue damage. 4 In 1987, Riedel HH et al 5 found that the levels of estrogen and progesterone decrease after fallopian tube sterilization and hysterectomy.…”

Section: Introductionmentioning

confidence: 99%

“…3,4 The logic behind this theory is that the vascularization of the ovaries by either ovarian artery or the uteroovarian anastomoses as well as the fallopian tube destruction reduce the utero-ovarian arterial blood flow in the mesosalpinx, which leads to ovarian tissue damage. 4 In 1987, Riedel HH et al 5 found that the levels of estrogen and progesterone decrease after fallopian tube sterilization and hysterectomy. 5 Nonetheless, Kusche M et al 6 in 1994 contradicted this finding by stating that no endocrinological parameters in the perimenopause were found, neither did cycle anomalies and ovarian deficiency symptoms in terms of climacteric complaints occur earlier, nor did early onset of menopause occur more often in the operated group.…”

Section: Introductionmentioning

confidence: 99%

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Tubal ligation and early menopause: a case-control study

Tayeh¹,

Naba²,

Habib³

et al. 2018

OGIJ

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Submit Manuscript | http://medcraveonline.com Abbreviations: BMI, body mass index; FSH, follicle stimulating hormone; HDF, hôtel-dieu de france BackgroundThe effect of the use of tubal sterilization as a birth control method on ovarian function, ovarian reserve and menopausal age is questionable. In fact, bilateral salpingectomy or tubal ligation 1 and conservative abdominal hysterectomy 2 were sometimes related to decrease ovarian function and premature menopause. The decrease of hormonal secretion will cause endocrine disorders manifested by decreased libido, vaginal dryness, mood swings and vasomotor symptoms. The alteration of the ovarian function by sterilization has been hypothesized to be responsible for menstrual abnormalities and hormonal disturbances that characterize the so-called posttubal ligation syndrome.3,4 The logic behind this theory is that the vascularization of the ovaries by either ovarian artery or the uteroovarian anastomoses as well as the fallopian tube destruction reduce the utero-ovarian arterial blood flow in the mesosalpinx, which leads to ovarian tissue damage. 4 In 1987, Riedel HH et al. 5 found that the levels of estrogen and progesterone decrease after fallopian tube sterilization and hysterectomy.5 Nonetheless, Kusche M et al. 6 in 1994 contradicted this finding by stating that no endocrinological parameters in the perimenopause were found, neither did cycle anomalies and ovarian deficiency symptoms in terms of climacteric complaints occur earlier, nor did early onset of menopause occur more often in the operated group. In this context, the objective of the present study was to compare age at menopause between the women having already undergone tubal ligation and the control group having intact fallopian tubes. Also, we review literature about the long-term safety of tubal ligation. Methods Study settings and populationFor the purpose of this case-control study, we retrospectively reviewed the medical records of all women (cases) who had previously undergone bilateral tubal ligation between 1970 and 2010 at the department of Obstetrics and Gynecology, Hôtel-Dieu de France (HDF) University Hospital, Beirut, Lebanon.More than 200 patients were contacted of whom many were found to have changed their phone numbers. Eligible cases had to be menopaused; menopause was defined as having amenorrhea for more than 12 months with or without symptoms related to hormonal depletion. Exclusion criteria were patients who were operated for bilateral ovariectomy or salpingectomy or hysterectomy before their physiological menopause, and patients who got chemotherapy, radiation therapy or any hormonal therapy that could influence their reproductive function and alter their normal evolution towards menopause.The 50 cases were then compared to 50 randomly chosen menopaused women (controls) from the department of Obstetrics and Gynecology at HDF, who did not get any tubal ligation or gynecological surgeries (intact tubes, ovaries and uterus) but meeting the same eligibility criteria as the cases....

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Post-tubal sterilization problems correlated with ovarian steroidogenesis

Cited by 52 publications

References 10 publications

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The comparison of the degree of apoptosis in ovaries and fallopian tubes between two different surgical interventions for tubal ligation: a rat-model

Tubal ligation and early menopause: a case-control study

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