Post-treatment Residual Clinicopathological Outcomes in Testicular Germ Cell Tumours

Nagaraj, Ranjitha Vodigenahalli; Rao, Vishal; Yoganarsimha, Jayakarthik; Fonseca, Daphne; Kodandapani, Suseela; Giridhar, Ashwin; Sharma, Rakesh; Rajappa, Senthil; Rao, T. Subramanyeshwar; Challa, Sundaram

doi:10.1007/s13193-021-01491-6

Cited by 1 publication

(4 citation statements)

References 21 publications

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“…[ 12 ] Malik et al and Nagaraj et al did not put forward their data on adjunctive procedures. [ 3 4 ] Singh et al had observed a similar frequency for adjunctive procedures. [ 5 ]…”

Section: Discussionmentioning

confidence: 99%

“…However, Nagaraj et al and Malik et al both reported 10% and 7% of viable tumors, respectively, the latter attributing this reduction to advancement in multimodality treatment. [ 3 4 ] Another possible hypothesis for the higher observation of viable tumors is that we included patients who received chemotherapy elsewhere and their protocols may not be standard. Furthermore, Nagaraj et al and Singh et al included seminoma in their cohort, and chemotherapy details were not available.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, Nagaraj et al and Singh et al included seminoma in their cohort, and chemotherapy details were not available. [ 4 5 ] Therefore, useful comparative deductions cannot be made.…”

Section: Discussionmentioning

confidence: 99%

“…[ 1 ] In India, about 30%–55% of the presenting population have International Union Against Cancer (UICC) prognostic group stage III disease at presentation, of which 20%–37% were of the Intermediate, and 13%–50% were of the Poor International Germ Cell Consensus Classifcation (IGCCC) prognostic risk groups at presentation. [ 2 3 4 5 6 ]…”

Section: Introductionmentioning

confidence: 99%

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Survival outcomes of postchemotherapy retroperitoneal lymph node dissection for nonseminomatous germ cell tumors: A retrospective cohort study from a single tertiary center in South India

Kumar,

Sadanala,

Nagasubramanian

et al. 2024

Indian Journal of Urology

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Introduction: Chemotherapy, postchemotherapy retroperitoneal lymph node dissection (pcRPLND), and metastasectomy remain the standard of care for the management of advanced nonseminomatous germ cell tumor (NSGCT). Methods: We retrospectively studied 73 patients who had pcRPLND at a single tertiary-care center (2003–2022). Surgical and clinicopathological features and oncological outcomes are presented. Results: The mean age was 28.27 years (15–48). Three-fourths had Stage III disease at diagnosis. International Germ Cell Cancer Collaborative Group risk stratification was 54.54% and 21.21% in intermediate risk, and poor risk, respectively. Sixty-two patients had Standard, 7 had Salvage and 4 underwent Desperation pcRPLND. Eleven patients (15.06%) required adjunctive procedures. Thirteen patients (17.8%) had ≥ class 3 Clavien–Dindo complications and postoperative mortality occurred in 5 (6.8%) patients. The histopathologies (HPE) of the pcRPLNDs were necrosis, teratoma, and viable tumor in 39.7%, 45.2%, and 15.1%, respectively. Seven patients underwent metastasectomy. An 85% size reduction in the size of RPLN predicted necrosis. There was 71.4% concordance between pcRPLND and metastasectomy HPEs. The median follow-up was 26.72 months (inter-quartile range – 13.25–47.84). The 2-year recurrence-free survival (RFS) rate was 93% (95% confidence interval [CI]–83%–97%) and the overall survival (OS) rate was 90% (95% CI–80%–95%). This is the largest series of pcRPLND for NSGCT in India to our knowledge. Conclusion: Although most of the cohort belonged to stage III, an RFS and OS rate of >90% at 2 years was achieved. We believe that successful management of postchemotherapy residual masses in NSGCT is contingent on the availability of multidisciplinary expertise and is therefore best done at tertiary-care referral centers.

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“…[ 12 ] Malik et al and Nagaraj et al did not put forward their data on adjunctive procedures. [ 3 4 ] Singh et al had observed a similar frequency for adjunctive procedures. [ 5 ]…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Furthermore, Nagaraj et al and Singh et al included seminoma in their cohort, and chemotherapy details were not available. [ 4 5 ] Therefore, useful comparative deductions cannot be made.…”

Section: Discussionmentioning

confidence: 99%