Post-traumatic stress disorders in patients with low-grade glioma and its association with survival

Health-related quality of life in adults with low-grade gliomas: a systematic review

“…Thirteen studies included a comparator and/or control group, comprising: HGG patients (n = 7) [34,38,39,43,45,46,53], non-cancer controls (NCC) (n = 6) [12,35,44,48,49,52], or benign brain tumour [34], suspected LGG [48], or non-Hodgkin's lymphoma (NHL)/chronic lymphocytic leukaemia (CLL) patients [12]. Thirteen different general, cancer-related, brain tumourspecific, or unidimensional HRQoL instruments were used, predominantly: EORTC QLQ-BN20 (n = 8) [12, 34, 41, 46-48, 53, 57], EORTC QLQ-C30 (n = 8) [34,40,41,46,47,52,53,57], SF-36 (n = 6) [12,42,44,45,48,49], FACT-Br (n = 3) [33,36,54], and EQ-5D (n = 2) [38,41]. Eleven studies used multiple HRQoL instruments [12, 33-35, 39, 41, 46-48, 50, 53, 57], often combining general (e.g.…”

“…Poor emotional functioning was reported in five (of 11) studies [33,34,40,52,54] and was significantly worse than NCCs in one (of one) of these [52]. General health perception was poor in four (of five) studies [12,42,48,49]; four (of four studies with an NCC group) found it was significantly worse in LGG patients than in NCCs [12,44,48,49]. Poor vitality was reported in four (of five) studies [12,42,48,49]; three (of four studies with an NCC group) found it was significantly worse than in NCCs [12,44,48], as well as suspected LGGs in one (of one) of these [48].…”

“…Studies were conducted across 13 countries: three each in the Netherlands [12, 30-32, 44, 48] and USA [33,36,37,39], two each in China [42,[54][55][56], Italy [35,45], India [34,46], Japan [47,53], and Norway [38,41], and one each in Australia [52], Finland [50,51], Germany [49], South Korea [43], Sweden [40], and Turkey [57] (Table 1; Supplementary Table S3). Sample size ranged from 15 to 260.…”

“…Only Affronti et al [33] reported ethnicity, for a predominantly white (93%) sample. Eleven studies reported SES [12,35,36,39,42,44,45,48,49,54,57] assessed through education, employment, or insurance status. Nine studies reported KPS [12, 33, 38, 41, 47-49, 54, 57]; scores ranged 60-100, but were mostly ≥ 80.…”

“…Tumour details included: grade (n = 5 studies) [31,43,52,54,57]; type (n = 12) [31, 33, 36, 40-42, 44, 45, 47, 49, 52, 53], predominantly astrocytoma, oligodendroglioma, and oligoastrocytoma; laterality (n = 13) [31,33,35,36,38,39,42,44,45,49,52,54,57]; and location (n = 12) [31,33,35,36,39,42,44,45,[47][48][49]57], largely frontal lobe. Four studies reported genetic markers [33,42,45,53]. Sixteen studies reported treatment [12, 33, 35, 36, 38, 40-42, 44, 45, 47, 48, 50, 52, 54, 57], including chemotherapy, radiotherapy, and extent of surgical resection.…”