Post-traumatic stress disorder as a comorbidity: impact on disease outcomes

Cavalcanti-Ribeiro, Patrícia; Andrade-Nascimento, Mônica; Morais-de-Jesus, Mychelle; Medeiros, Givaldo Melquíades de; Daltro-Oliveira, Renato; Conceição, Jenisson Oliveira; Rocha, Mateus Garcia; Miranda‐Scippa, Ângela; Koenen, Karestan C.; Quarantini, Lucas C.

doi:10.1586/ern.12.77

Cited by 47 publications

(30 citation statements)

References 144 publications

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“…Nonetheless, over the past 2 decades, considerable research with other cancer patient populations has established that PTSD symptoms after a cancer diagnosis, as for other traumatic events, are distinct from depression or general anxiety in that symptoms occur in response to a specific threatening event and include specific responses to triggers reminding the person of the event, although there is some comorbidity between PTSD and these other mood disorders . The potential clinical implications of PTSD in patients with cancer are suggested by accumulating evidence that PTSD can have particularly pernicious health‐related consequences, including increased sensitivity to pain and other physical health symptoms, as well as increased morbidity and mortality …”

Section: Introductionmentioning

confidence: 99%

Posttraumatic stress disorder symptoms in newly diagnosed patients with head and neck cancer and their partners

et al. 2014

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Background Head and neck cancer is a life threatening illness requiring aversive treatments. Despite clear potential for posttraumatic stress disorder (PTSD) symptoms in both patients and their partners, research is scant. Methods Newly diagnosed patients and partners (no. of dyads=42) completed questionnaires to assess symptoms of PTSD, anxiety, and depression, as well as demographic, medical, and attitudinal variables. Results Partners had higher average levels of PTSD symptoms than patients (p=.023). More partners (28.6%) met criteria for estimated PTSD caseness than did patients (11.9%). There were no significant differences in levels of other anxiety or depression symptoms. Perceived threat of disease appears to be a stronger correlate of PTSD symptom levels than medical variables in patients and partners. Conclusions A diagnosis of head and neck cancer elicits significant levels of PTSD symptoms in patients, and even higher levels among partners. Identified correlates of distress, including perceived threat of disease, are potential intervention targets.

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Section: Introductionmentioning

confidence: 99%

Posttraumatic stress disorder symptoms in newly diagnosed patients with head and neck cancer and their partners

et al. 2014

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“…One basic and still unanswered question is whether PTSS, which are quite common in some settings , necessarily represent a clinically significant problem, or are simply a normal response to a stressful situation. Although the number of required symptoms for a diagnosis of PTSD is defined in DSM‐5, it is unclear how many PTSD symptoms must be present to reach a clinically significant threshold within a medically ill population.…”

Section: Resultsmentioning

confidence: 99%

“…As defined by the DSM‐5 , PTSD is precipitated by an emotionally traumatic event and is characterized by re‐experiencing symptoms, avoidance of trauma‐related stimuli, negative alterations in cognitions and mood, and alterations in arousal and reactivity. The experiences that accompany being diagnosed with serious medical illnesses, or with their treatment (such as surgical interventions, including transplantation), have been shown to be associated with the development of PTSD or subdiagnostic symptoms of PTSD (called PTSS) .…”

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confidence: 99%

PTSD in solid organ transplant recipients: Current understanding and future implications

Supelana

Annunziato

Kaplan

et al. 2015

Pediatric Transplantation

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Posttraumatic stress symptoms (PTSS) are quite prevalent in transplant recipients, although full-scale posttraumatic stress disorder (PTSD) may not be that common. Those symptoms have been linked to poor transplant outcomes, perhaps owing to nonadherence to medications and other recommendations, brought about by the avoidance dimension of the PTSD/PTSS construct (patients may avoid taking their medications because they serve as reminder of the emotionally traumatic event – the transplant). Since it is possible to treat PTSD via specific psychotherapeutic techniques, and the treatment has been shown to be safe and likely effective in other populations, it would appear that the practitioners who treat transplant recipients should be familiar with the presentation and treatment of those symptoms. The present manuscript provides a systematic literature review of the PTSD/PTSS presentation in the pediatric transplant setting, a synthesis of available research findings, and suggestions for current care and future research.

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“…10,11 PTSD has been postulated to be associated with modification of stress response in the body as well as causing a pro-inflammatory state. [13][14][15][16][17] PTSD has also been shown to be associated with other psychiatric comorbidities (depression, anxiety), substance abuse, and noncompliance with medications and follow-up. [13][14][15][16][17] PTSD has also been shown to be associated with other psychiatric comorbidities (depression, anxiety), substance abuse, and noncompliance with medications and follow-up.…”

Section: Introductionmentioning

confidence: 99%

History of posttraumatic stress disorder and outcomes after kidney transplantation

Siwakoti

Potukuchi

Thomas

et al. 2019

American Journal of Transplantation

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A history of posttraumatic stress disorder (PTSD), if uncontrolled, represents a contraindication for kidney transplantation. However, no previous large study has assessed the association between pretransplant history of PTSD and posttransplantation outcomes. We examined 4479 US veterans who had undergone transplantation. The diagnosis of history of PTSD was based on a validated algorithm. Measured covariates were used to create a matched cohort (n = 560). Associations between pretransplant PTSD and death with functioning graft, all-cause death, and graft loss were examined in survival models. Posttransplant medication nonadherence was assessed using proportion of days covered (PDC). From among 4479 veterans, 282 (6.3%) had a history of PTSD. The mean age ± standard deviation (SD) of the cohort at baseline was 61 ± 11 years, 91% were male, and 66% and 28% of patients were white and African American, respectively. Compared to patients without a history of PTSD, patients with a history of PTSD had a similar risk of death with a functioning graft (subhazard ratio [SHR] 0.97, 95% confidence interval [CI] 0.61-1.54), all-cause death (1.05, 0.69-1.58), and graft loss (1.09, 0.53-2.26). Moreover, there was no difference in | 2295 SIWAKOTI eT Al.

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Post-traumatic stress disorder as a comorbidity: impact on disease outcomes

Cited by 47 publications

References 144 publications

Posttraumatic stress disorder symptoms in newly diagnosed patients with head and neck cancer and their partners

Posttraumatic stress disorder symptoms in newly diagnosed patients with head and neck cancer and their partners

PTSD in solid organ transplant recipients: Current understanding and future implications

History of posttraumatic stress disorder and outcomes after kidney transplantation

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