Post-traumatic Stress Disorder: A Review of Therapeutic Role of Meditation Interventions

Jayatunge, Ruwan M.; Pokorski, Mieczysław

doi:10.1007/5584_2018_167

Cited by 6 publications

(4 citation statements)

References 53 publications

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“…PTSD is a global health issue and has a serious negative impact on individuals and society, the prevalence of PTSD is high and it substantially increases the risk of other psychiatric morbidities as well as medical disorders ( 2 – 4 ). Although the current studies have identified the molecular, neurochemical and genetic abnormalities associated with of PTSD ( 5 ), prevention and treatment of PTSD are limited ( 4 , 6 ).…”

Section: Introductionmentioning

confidence: 99%

Minocycline Attenuates Stress-Induced Behavioral Changes via Its Anti-inflammatory Effects in an Animal Model of Post-traumatic Stress Disorder

Wang

et al. 2018

Front. Psychiatry

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Accumulating evidences have suggested that anxiety-like behavior and impairment of learning and memory are key symptoms of post-traumatic stress disorder (PTSD), and pharmacological treatment can ameliorate anxiety and cognitive impairments. Recent studies have shown that minocycline exhibits anxiolytic effects. The aims of the present study were to determine whether minocycline administration would alter anxiety-like behavior and cognitive deficits induced by inescapable foot shock (IFS) and to explore the underlying mechanisms. Male Wistar rats were exposed to the IFS protocol for a period of 6 days to induce PTSD. The PTSD-like behavior was tested using the open field test, elevated plus maze test, and Morris water maze test. The effects of minocycline on pro-inflammatory cytokines, activation of microglia, and NF-κB in the PFC and hippocampus were also examined. Treatment with minocycline significantly reversed the IFS induced behavioral and cognitive parameters (impaired learning and memory function) in stressed rats. Additionally, IFS was able to increase pro-inflammatory cytokines, activate microglia, and enhance NF-κB levels, while minocycline significantly reversed these alterations. Taken together, our results suggest that the anxiolytic effect of minocycline is related to its ability to decrease the levels of pro-inflammatory cytokines and inhibit activation of microglia and NF-κB in the PFC and hippocampus.

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Section: Introductionmentioning

confidence: 99%

Minocycline Attenuates Stress-Induced Behavioral Changes via Its Anti-inflammatory Effects in an Animal Model of Post-traumatic Stress Disorder

Wang

et al. 2018

Front. Psychiatry

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“…Post-traumatic stress disorder: a review of therapeutic role of meditation interventions 20 Revisão de literatura que indicou benefícios da meditação em distúrbios de stress póstraumático através do cultivo de consciência, alterações de comportamento e alteração das experiências emocionais.…”

Section: Mindfulnessunclassified

“…Outro estudo sugeriu a utilização da meditação para alívio dos sintomas e como tratamento -unido a farmacoterapia e de maneira isolada -dos distúrbios póstraumáticos, tendo em vista a ausência de orientação e ampla disponibilidade de medicamentos utilizados, como por exemplo, os inibidores da recaptação de serotonina, inibidores da monoamina oxidase e antidepressivos tricíclicos 20 .…”

Section: Medicamentos E Meditação: As Relaçõesunclassified

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Autoconhecimento e saúde: a meditação e o uso irracional de medicamentos

Menezes

Gomides²,

Lima³

2022

Rev Neurocienc

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Introdução. A prática da meditação tem apresentado inúmeras vantagens no cenário terapêutico e preventivo. Estudos apontam a técnica como ferramenta para minimizar a dependência farmacológica, importante em casos de uso irracional. Objetivo. O presente estudo destaca exercícios meditativos e seus principais benefícios associados. Método. Para tal, foi realizada uma revisão da literatura nas bases de dados: Biblioteca Virtual em Saúde (BVS), Medical Literature Analysis and Retrieval System Online (Pubmed) e Directory of Open Acess Journals (DOAJ), em inglês, com os descritores “meditation” e “pharmacotherapy”. Resultado. Foram incluídos 14 estudos, publicados entre 2018 e 2020, permitindo a análise por três categorias: o processo de autoconhecimento humano; o uso de diferentes técnicas na clínica; a associação à terapia medicamentosa no processo de cura. Conclusão. A partir da análise, foram apresentados particularidades e benefícios das técnicas meditativas Heartfulness e Mindfulness-Based, como: opção terapêutica isolada ou adjuvante, redução da frequência e dosagem de medicamentos e ampliação do autoconhecimento. Os achados sugerem o potencial de reescrever o caminho de cuidado em saúde através da meditação, reduzindo efeitos adversos das terapias convencionais e intensificando a exclusão de maus hábitos inconscientes.

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Preoperative Rehabilitation in Lung Cancer Patients: Yoga Approach

Barassi

Fulle

Iulio³

et al. 2018

Advances in Experimental Medicine and Biology

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Lung cancer is one of the leading causes of cancer death worldwide. Surgical removal remains the best option for most tumors of this type. Reduction of cigarette consumption in patients with lung cancer candidates for the surgery could limit the impact of tobacco on postsurgical outcomes. Breathing exercises appear to help combat cigarette cravings. Yoga exercise benefits have been studied in lung cancer survivors, rather than in the preoperative setting. In this study, we have recruited 32 active smokers affected by lung cancer and being candidates for pulmonary surgery. The patients were randomly assigned to two groups: one treated by standard breathing and the other treated by yoga breathing (YB). The groups were evaluated at times T0 (baseline) and T1 (after 7 days of treatment) to compare the effects of the two breathing treatments on pulmonary performance in a presurgery setting. Pulmonary and cardiocirculatory functions have been tested using a self-calibrating computerized spirometer and a portable pulse oximetry device. The findings demonstrate appreciable short-term improvement in lung function assessed by spirometry. We conclude that yoga breathing can be a beneficial preoperative support for thoracic surgery.

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Post-traumatic Stress Disorder: A Review of Therapeutic Role of Meditation Interventions

Cited by 6 publications

References 53 publications

Minocycline Attenuates Stress-Induced Behavioral Changes via Its Anti-inflammatory Effects in an Animal Model of Post-traumatic Stress Disorder

Minocycline Attenuates Stress-Induced Behavioral Changes via Its Anti-inflammatory Effects in an Animal Model of Post-traumatic Stress Disorder

Autoconhecimento e saúde: a meditação e o uso irracional de medicamentos

Preoperative Rehabilitation in Lung Cancer Patients: Yoga Approach

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