Post-traumatic psychiatric disorders: PTSD is not the only diagnosis

Auxéméry, Yann

doi:10.1016/j.lpm.2017.12.006

Cited by 76 publications

(61 citation statements)

References 77 publications

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“…Though the current review focuses on depression, it is notable that chronic stress is a risk factor for virtually all psychiatric conditions 139 . Likewise, the neural, cognitive, information processing, and psychological patterns discussed above have broad transdiagnostic relevance, particularly with respect to other disorders of negative affect (e.g., anxiety, trauma-related conditions) 140 -that likewise respond to pharmacologic interventions with plasticity-enhancing properties 141,142 .…”

Section: Generalizability and Transdiagnostic Relevancementioning

confidence: 99%

Neuroplasticity in cognitive and psychological mechanisms of depression: an integrative model

2019

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Chronic stress and depressive-like behaviors in basic neuroscience research have been associated with impairments of neuroplasticity, such as neuronal atrophy and synaptic loss in the medial prefrontal cortex (mPFC) and hippocampus. The current review presents a novel integrative model of neuroplasticity as a multi-domain neurobiological, cognitive, and psychological construct relevant in depression and other related disorders of negative affect (e.g., anxiety). We delineate a working conceptual model in which synaptic plasticity deficits described in animal models are integrated and conceptually linked with human patient findings from cognitive science and clinical psychology. We review relevant reports including neuroimaging findings (e.g., decreased functional connectivity in prefrontal-limbic circuits), cognitive deficits (e.g., executive function and memory impairments), affective information processing patterns (e.g., rigid, negative biases in attention, memory, interpretations, and self-associations), and patient-reported symptoms (perseverative, inflexible thought patterns; inflexible and maladaptive behaviors). Finally, we incorporate discussion of integrative research methods capable of building additional direct empirical support, including using rapid-acting treatments (e.g., ketamine) as a means to test this integrative model by attempting to simultaneously reverse these deficits across levels of analysis.Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:

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Section: Generalizability and Transdiagnostic Relevancementioning

confidence: 99%

Neuroplasticity in cognitive and psychological mechanisms of depression: an integrative model

2019

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“…Trauma can be a result of either (or both) a deep emotional pain, and/or a life-threatening event (psychological) or a physiological injury or impact against the body (physical). Recent research has indicated that both physical [15] and psychological [14] trauma share physiological properties [1,19].…”

Section: Introductionmentioning

confidence: 99%

ΔMST and the Regulation of Cardiac CSE and OTR Expression in Trauma and Hemorrhage

et al. 2021

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Genetic deletion of 3-mercaptopyruvate sulfurtransferase (MST) is known to result in hypertension and cardiac hypertrophy in older mice, and is associated with increased anxiety-like behaviors. Endogenous hydrogen sulfide (H2S) produced by MST in the mitochondria is also known to be involved in physiological and cellular bioenergetics, and its dysfunction associated with depressive behavior and increased cardiovascular morbidity. Interestingly, early life stress has been shown to lead to a significant loss of cystathionine-γ-lyase (CSE) and oxytocin receptor (OTR) expression in the heart. Thus, we were interested in testing the hypothesis of whether genetic MST mutation (ΔMST) would affect cardiac CSE and OTR expression and affect the mitochondrial respiration in a clinically relevant, resuscitated, mouse model of trauma and hemorrhagic shock. In ΔMST mice, we found a reduction of CSE and OTR in both the naive as well as injured state, in contrast to the wild type (wt) controls. Interestingly, the ΔMST showed a different complex IV response to injury than the wt controls, although our claims are based on the non-demonstrated assumption that naive wt and naive ΔMST mice have comparable complex IV activity. Finally, hemorrhagic shock led to a reduction of CSE and OTR, confirming previous results in the injured mouse heart. To date, the exact mechanisms of the cardiac interaction between H2S and OT are not clear, but they point the way to potential cardioprotective therapies.

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“…In contrast, physical trauma can be defined as physiological injury or an impact against the body. Current research underscores the fact that physical and psychological trauma share physiological correlates [ 3 ]. OT and H 2 S are relevant in models of both psychological and physical trauma, displaying cardio-protective, anti-oxidative and anti-inflammatory effects [ 4 , 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

The Interaction of the Endogenous Hydrogen Sulfide and Oxytocin Systems in Fluid Regulation and the Cardiovascular System

et al. 2020

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The purpose of this review is to explore the parallel roles and interaction of hydrogen sulfide (H2S) and oxytocin (OT) in cardiovascular regulation and fluid homeostasis. Their interaction has been recently reported to be relevant during physical and psychological trauma. However, literature reports on H2S in physical trauma and OT in psychological trauma are abundant, whereas available information regarding H2S in psychological trauma and OT in physical trauma is much more limited. This review summarizes recent direct and indirect evidence of the interaction of the two systems and their convergence in downstream nitric oxide-dependent signaling pathways during various types of trauma, in an effort to better understand biological correlates of psychosomatic interdependencies.

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Post-traumatic psychiatric disorders: PTSD is not the only diagnosis

Cited by 76 publications

References 77 publications

Neuroplasticity in cognitive and psychological mechanisms of depression: an integrative model

Neuroplasticity in cognitive and psychological mechanisms of depression: an integrative model

ΔMST and the Regulation of Cardiac CSE and OTR Expression in Trauma and Hemorrhage

The Interaction of the Endogenous Hydrogen Sulfide and Oxytocin Systems in Fluid Regulation and the Cardiovascular System

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