Post-traumatic osteoarthritis (PTOA) animal model to understand pathophysiology of osteoarthritis

Singleton, Quante; Bapat, Santul; Fulzele, Sadanand

doi:10.21037/atm.2019.04.05

Cited by 4 publications

(2 citation statements)

References 10 publications

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“…PTOA is mainly caused by trauma and is characterized by joint pain and biomechanical dysfunction (23). With the devel� opment of PTOA, disability develops and may seriously affect the quality of life of patients (1).…”

Section: Discussionmentioning

confidence: 99%

Reduced miR‑519d‑3p levels in the synovium and synovial fluid facilitate the progression of post‑traumatic osteoarthritis by targeting VEGF

Gao

Xia

2021

Exp Ther Med

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T�� T�� sion and clinical significance of miR-519d-3p in patients with post-traumatic osteoarthritis (PTOA). The levels of miR-519d-3p in the synovium and synovial fluid (SF) of all subjects were detected by reverse transcription-quantitative polymerase chain reaction. The results of the present study demonstrated that the levels of miR-519d-3p in the synovium and SF of patients with PTOA were significantly lower, but that the VEGF content was significantly higher, compared with that of control group. Dual-luciferase reporter and Western blot assays demonstrated that VEGF was a target gene of miR-519d-3p. Furthermore, miR-519d-3p inhibitor-induced cell apoptosis, and cell cycle arrest could be partially reversed by silencing VEGF. Additionally, the level of miR-519d-3p in the synovium and SF of patients with PTOA was negatively correlated with the level of VEGF. ROC analysis demonstrated that miR-519d-3p levels in the synovium and SF could effectively differentiate patients with PTOA from healthy controls, with areas under the ROC curve of 0.928 and 0.896, respectively. In conclusion, reduction of miR-519d-3p in the synovium and SF resulted in the upregu� lation of VEGF in patients with PTOA, and miR-519d-3p may be a potential therapeutic target of PTOA.

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Section: Discussionmentioning

confidence: 99%

Reduced miR‑519d‑3p levels in the synovium and synovial fluid facilitate the progression of post‑traumatic osteoarthritis by targeting VEGF

Gao

Xia

2021

Exp Ther Med

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“…The pathological features of PTOA involve the whole joint tissues, including cartilage degradation, subchondral bone remodeling, osteophyte formation and synovial inflammation. Among them, articular cartilage degeneration is the core pathogenesis of PTOA [ 9 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Autophagy in the pathogenesis and therapeutic potential of post-traumatic osteoarthritis

Gong

et al. 2023

Burns &Amp; Trauma

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Autophagy, as a fundamental mechanism for cellular homeostasis, is generally involved in the occurrence and progression of various diseases. Osteoarthritis (OA) is the most common musculoskeletal disease that often leads to pain, disability and economic loss in patients. Post-traumatic OA (PTOA) is a subtype of OA, accounting for >12% of the overall burden of OA. PTOA is often caused by joint injuries including anterior cruciate ligament rupture, meniscus tear and intra-articular fracture. Although a variety of methods have been developed to treat acute joint injury, the current measures have limited success in effectively reducing the incidence and delaying the progression of PTOA. Therefore, the pathogenesis and intervention strategy of PTOA need further study. In the past decade, the roles and mechanisms of autophagy in PTOA have aroused great interest in the field. It was revealed that autophagy could maintain the homeostasis of chondrocytes, reduce joint inflammatory level, prevent chondrocyte death and matrix degradation, which accordingly improved joint symptoms and delayed the progression of PTOA. Moreover, many strategies that target PTOA have been revealed to promote autophagy. In this review, we summarize the roles and mechanisms of autophagy in PTOA and the current strategies for PTOA treatment that depend on autophagy regulation, which may be beneficial for PTOA patients in the future.

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Frailty and pain, human studies and animal models

D’Agnelli

Amodeo

Franchi

et al. 2022

Ageing Research Reviews

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Post-traumatic osteoarthritis (PTOA) animal model to understand pathophysiology of osteoarthritis

Cited by 4 publications

References 10 publications

Reduced miR‑519d‑3p levels in the synovium and synovial fluid facilitate the progression of post‑traumatic osteoarthritis by targeting VEGF

Reduced miR‑519d‑3p levels in the synovium and synovial fluid facilitate the progression of post‑traumatic osteoarthritis by targeting VEGF

Autophagy in the pathogenesis and therapeutic potential of post-traumatic osteoarthritis

Frailty and pain, human studies and animal models

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