Post‐traumatic osteoarthritis: Improved understanding and opportunities for early intervention

Anderson, Donald D.; Chubinskaya, Susan; Guilak, Farshid; Martin, James A.; Oegema, Theodore R.; Olson, Steven A.; Buckwalter, Joseph A.

doi:10.1002/jor.21359

Cited by 534 publications

(506 citation statements)

References 58 publications

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“…This observation conforms to clinical literature that lists OA as a common fracture complication (Anderson et al 2011). Small sample sizes prohibited description of the distribution of OA by sex, but the fact that the observable joint surfaces of fractures with deformity (i.e., linear and/or rotation) greater than 15 degrees all exhibit OA, provides further evidence to support the post-traumatic development of this condition in bones that have healed with deformities (Van Der Schoot et al 1996).…”

Section: Healing and Treatmentsupporting

confidence: 84%

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Gendered Differences in Accidental Trauma to Upper and Lower Limb Bones at Aquincum, Roman Hungary

Gilmour

Gowland

Roberts

et al. 2015

International Journal of Paleopathology

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Additional information:Use policyThe full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-pro t purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details. AbstractIt is hypothesized that men and women living in the border provinces of the Roman Empire may have encountered different physical dangers associated with variation in their occupations and activities. Limb bone trauma data were used to assess sex-based differences in physical hazards and evidence for fracture healing and treatment. Two hundred and ten skeletons were examined from a late 1 st to early 4 th century AD cemetery at Aquincum (Budapest, Hungary). Upper and lower limb bone fracture types, frequencies, distributions, and associated complications were recorded, and gendered patterns in injury risks were explored. Of the 23 fractures identified, both sexes had injuries indicative of falls; males exhibited the only injuries suggestive of higherenergy and more direct forces. Most fractures were well-healed with few complications. The extremity trauma at Aquincum suggests that people buried here experienced less hazardous physical activities than at other Roman provincial sites. The patterns of trauma indicate that "traditional" gender roles were in place, whereby male civilians participated in more physically dangerous activities than females. Additionally, treatment may have been equally accessible to men and women, but certain fracture types proved more challenging to reduce using the techniques available.

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Section: Healing and Treatmentsupporting

confidence: 84%

“…Osteoarthritis (OA) may develop following trauma, particularly in the case of poorly aligned fractures and injuries involving joints (Anderson et al 2011;Rogers and Waldron 1995).…”

mentioning

confidence: 99%

Gendered Differences in Accidental Trauma to Upper and Lower Limb Bones at Aquincum, Roman Hungary

Gilmour

Gowland

Roberts

et al. 2015

International Journal of Paleopathology

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“…Although the development of posttraumatic osteoarthritis is particularly rapid following intra-articular fracture 22,23 , the diversity in fracture patterns, acuity, and severity render it difficult to study pathogenesis in humans. To identify and evaluate new treatment targets in a controlled setting, effective animal models of intra-articular fracture are needed 24 . The development, application, and implications of a small animal intra-articular fracture model were highlighted in the symposium.…”

Section: Early Diagnosis Enables Early Treatment To Reduce Osteoarthrmentioning

confidence: 99%

Osteoarthritis: From Palliation to Prevention

Chu

Millis

Olson

2014

The Journal of Bone and Joint Surgery

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Osteoarthritis is a leading cause of disability. The traditional focus on late-stage osteoarthritis has not yielded effective disease-modifying treatments. Consequently, current clinical care focuses on palliation until joint replacement is indicated. A symposium format was used to examine emerging strategies that support the transformation of the clinical approach to osteoarthritis from palliation to prevention. Central to this discussion are concepts for diagnosis and treatment of pre-osteoarthritis, meaning joint conditions that increase the risk of accelerated development of osteoarthritis. The presentation of translational and clinical research on three common orthopaedic conditions-anterior cruciate ligament tear, intra-articular fracture, and hip dysplasia-were used to illustrate these ideas. New information regarding the use of novel quantitative magnetic resonance imaging (MRI) in the form of ultrashort echo time enhanced T2* (UTE-T2*) mapping to evaluate the potential for articular cartilage to heal subsurface damage in a mechanically sound environment was presented. These data indicate that improved diagnostics can both identify cartilage at risk and evaluate the effectiveness of early treatment strategies. With use of a new mouse model for intra-articular fracture, it was shown that inflammation correlated to fracture severity and that super-healer mice avoided early posttraumatic osteoarthritis in part through an enhanced ability to dampen inflammation. These findings suggest that there is a role for acute and sustained anti-inflammatory treatment in the prevention of osteoarthritis. For long-term treatment, contemporary gene-therapy approaches may offer an effective means for sustained intra-articular delivery of anti-inflammatory and other bioactive agents to restore joint homeostasis. To illustrate the potential of early treatment to prevent or delay the onset of disabling osteoarthritis, the positive clinical effects on articular cartilage and in long-term clinical follow-up after operative correction of structural abnormalities about the hip highlight the role for targeting mechanical factors in delaying the onset of osteoarthritis. Given that orthopaedic surgeons treat the full spectrum of joint problems, ranging from joint trauma to preosteoarthritic conditions and end-stage osteoarthritis, an awareness of the paradigm shift toward the prevention of osteoarthritis is critical to the promotion of improved clinical care and participation in clinical research involving new treatment strategies.

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“…1) [1]. Aggrecan fragments associated with matrix breakdown can be significantly elevated immediately following joint trauma [2].…”

Section: Pathophysiologic Responses To Joint Injurymentioning

confidence: 99%

Chondroprotection Following Acute Joint Injury: Prevention of Osteoarthritis

2012

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Post‐traumatic osteoarthritis: Improved understanding and opportunities for early intervention

Cited by 534 publications

References 58 publications

Gendered Differences in Accidental Trauma to Upper and Lower Limb Bones at Aquincum, Roman Hungary

Gendered Differences in Accidental Trauma to Upper and Lower Limb Bones at Aquincum, Roman Hungary

Osteoarthritis: From Palliation to Prevention

Chondroprotection Following Acute Joint Injury: Prevention of Osteoarthritis

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