Post-Traumatic Osteoarthritis Assessment in Emerging and Advanced Pre-Clinical Meniscus Repair Strategies: A Review

Trivedi, Jay; Betensky, Daniel; Desai, Salomi; Jayasuriya, Chathuraka T.

doi:10.3389/fbioe.2021.787330

Cited by 6 publications

(5 citation statements)

References 116 publications

(97 reference statements)

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“…In fact, according to a 2020 epidemiological study of young adults, approximately 13% of patients with meniscus injury develop OA 18 years after injury. The 8-week-old rats used in this experiment are also common in the PTOA model, consistent with the age stage of young rats [ 17 , 18 ]. Currently, the treatment strategies for PTOA primarily aim to restore proper kinematic and biomechanical conditions and mitigate the inflammatory response.…”

Section: Discussionsupporting

confidence: 61%

Exercise-induced modulation of myokine irisin on muscle-bone unit in the rat model of post-traumatic osteoarthritis

Shang,

Hao,

Hou

et al. 2024

J Orthop Surg Res

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Background and aim Post-traumatic osteoarthritis (PTOA) is a subtype of osteoarthritis (OA). Exercise may produce and release the myokine irisin through muscle fiber contraction. However, the effect of exercise-promoted irisin production on the internal interactions of the muscle–bone unit in PTOA studies remains unclear. Methods Eighteen 8-week-old Sprague–Dawley (SD) rats were randomly divided into three groups: Sham/sedentary (Sham/Sed), PTOA/sedentary (PTOA/Sed), and PTOA/treadmill-walking (PTOA/TW). The PTOA model was established by transection of anterior cruciate ligament (ACLT) and destabilization of medial meniscus (DMM). After 4 weeks of modeling, the PTOA/TW group underwent treadmill exercise (15 m/min, 30 min/d, 5 d/ week, 8 weeks), and the other two groups were free to move in the cage. Evaluation and correlation analysis of muscle, cartilage, subchondral bone and serological indexes were performed after euthanasia. Results Eight weeks of treadmill exercise effectively alleviated the trauma-induced OA phenotype, thereby maintaining cartilage and subchondral bone integrity in PTOA, and reducing quadriceps atrophy and myofibril degradation. Exercise reversed the down-regulated expression of peroxisome proliferator-activated receptor-gamma coactivator-1α (PGC-1α) and fibronectin type III structural domain protein 5 (FNDC5) in muscle tissue of PTOA rats, and increased the blood irisin level, and the irisin level was positively correlated with the expression of PGC-1α and FNDC5. In addition, correlation analysis showed that irisin metabolism level was strongly negatively correlated with Osteoarthritis Research Society International (OARSI) and subchondral bone loss, indicating that irisin may be involved in cartilage biology and PTOA-related changes in cartilage and subchondral bone. Moreover, the metabolic level of irisin was strongly negatively correlated with muscle fiber cross-sectional area (CSA), Atrogin-1 and muscle ring-finger protein-1(MuRF-1) expression, suggesting that irisin may alleviate muscle atrophy through autocrine action. Conclusion Treadmill exercise can alleviate the atrophy and degeneration of muscle fibers in PTOA rats, reduce the degradation of muscle fibrin, promote the expression of serum irisin, and alleviate the degeneration of articular cartilage and subchondral bone loss in PTOA rats. These results indicate that treadmill exercise can affect the process of PTOA by promoting the expression of myokine irisin in rat muscle–bone unit.

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Section: Discussionsupporting

confidence: 61%

Exercise-induced modulation of myokine irisin on muscle-bone unit in the rat model of post-traumatic osteoarthritis

Shang,

Hao,

Hou

et al. 2024

J Orthop Surg Res

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“…Previous biomechanical studies have shown that repairing the posterior root of the medial meniscus can restore the ability of the posterior root of the meniscus, absorb circumferential stress and reduce the contact pressure of the tibiofemoral joint, which is equivalent to that of the natural knee joint [11]. Unfortunately, meniscus repair of knee osteoarthritis has a higher progressive rate than the natural incidence of healthy knee [42]. An earlier cadaver study compared the contact mechanics of the tibiofemoral joint between anatomical and non-anatomical repair of the root tear.…”

Section: Discussionmentioning

confidence: 99%

Biomechanical assessment of disease outcome in surgical intervention for medial meniscal posterior root tears: efficacy and considerations

Rao

et al. 2022

Preprint

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Background The adverse consequences of medial meniscus posterior root tear have become more and more familiar to surgeons, and the treatment strategies have become increasingly abundant. In this paper, the finite element gait analysis method was used to explore the differences in the biomechanical characteristics of the knee joint under different conditions. Methods The CT computed tomography images of the knee joint were collected, and the CT two-dimensional tomographic images were converted into three-dimensional models through the procedures of gray value adjustment and regional growth. A structure with bone, cartilage, and meniscus was constructed (i) a finite element model of the intact knee joint. Next (ii) the slight tear model, (iii) the severe tear model, (iv) the entire tear model, (v) partial meniscectomy model, and (vi) meniscus repair model were constructed on the basis of the intact knee joint model. Different models were developed and analyzed under normal gait loading conditions. Results Under the gait load, the contact mechanics, kinematics and contact area of the medial and lateral interarticular compartment of the slight tear model and the severe tear model were not significantly different from those of the intact knee joint, while the severe tear model was significantly higher than the intact knee joint in the comparison of the local stress of the posterior root of the meniscus, and the average stress and peak stress increased by 267.1% and 202.9%, respectively. In addition, by comparing the performance of the partial meniscectomy model with the intact knee joint model, it can be concluded that partial meniscectomy did not show an improvement in cartilage contact behavior, and the average stress in the medial compartment still increased by 19.9%. The average contact area of femur and tibial cartilage decreased by 40.7% and 17.7% respectively. Meniscus repair has excellently achieved the task of restoring the biomechanics of the medial meniscus, and it is worth noting that it has also paid a high cost to achieve this benign outcome. The average stress of the posterior root of meniscus and tibial plateau increased by 127.1% and 271.6% respectively compared with the intact model. Conclusions The biomechanics of the knee joint is not sensitive to the level of tear of the posterior root. The improvement of partial meniscectomy in relieving intra-articular overload is limited, and the risk factors for accelerating the progression of osteoarthritis still exist. Meniscus repair is recommended for patients with medial meniscus posterior root tear to restore the biomechanical properties of the meniscus.

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“…Это регулярное (курсовое) введение ГлК, МСК и обогащенной тромбоцитами плазмы, аллогенная трансплантация хондроцитов, а также назначение симптоматических средств замедленного действия в терапии остеоартрита (Symptomatic Slow Acting Drugs for Osteoarthritis, SYSADOA), к которым относятся хондроитин, глюкозамин, диацереин, неомыляемые соединения авокадо и сои. Третий принцип -обязательное подключение немедикаментозных средств, продуманная фи-зическая и социальная реабилитация, что особенно существенно, поскольку большинство пациентов с ПТОА -лица молодого трудоспособного возраста, для которых крайне важно максимально полное и быстрое восстановление физической активности [48][49][50][51].…”

Section: реальная практикаunclassified

Post-traumatic osteoarthritis: epidemiology, pathogenesis, clinical picture, approaches to pharmacotherapy

Karateev¹,

Chernikova²,

Макаров³

2023

Sovremennaâ revmatologiâ

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Post-traumatic osteoarthritis (PTOA) is an inflammatory and degenerative disease that occurs as a result of the joint structures injury. It is a common pathology, accounting for approximately 12% of all cases of osteoarthritis (OA). PTOA often occurs in people of young productive age, progresses rapidly, causing chronic pain and increasing dysfunction. Individuals undergoing joint replacement for PTOA are, on average, 10 years younger than those with primary OA. The time interval from the moment of injury to the onset of typical PTOA radiological signs varies widely – from 1 year to 15–20 years.The main injuries that cause PTOA are intra-articular fractures, anterior cruciate ligament injuries, meniscus rupture and dislocation of the patella of the knee joint, joint dislocations with damage to the ligamentous apparatus of the ankle and shoulder joints.The pathogenesis of PTOA is determined by chronic inflammation accompanied by macrophage activation, hyperproduction of cytokines, primarily interleukin (IL) 1â, chemokines and growth factors, progressive destruction of joint tissue and degenerative changes (fibrosis, neoangiogenesis, osteophytosis).Pathogenetic treatment of PTOA, which would stop the progression of the disease, has not been developed. The possibility of using inhibitors of IL1â, IL6, inhibitors of tumor necrosis factor á, glucocorticoids, hyaluronic acid, autologous cell based therapy is under study. The control of pain and inflammation in PTOA requires the prescription of traditional drugs that are widely used in the practice of managing patients with primary OA. In particular, the use of symptomatic delayed-acting agents, such as the injectable form of chondroitin sulfate, seems to be appropriate.

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Post-Traumatic Osteoarthritis Assessment in Emerging and Advanced Pre-Clinical Meniscus Repair Strategies: A Review

Cited by 6 publications

References 116 publications

Exercise-induced modulation of myokine irisin on muscle-bone unit in the rat model of post-traumatic osteoarthritis

Exercise-induced modulation of myokine irisin on muscle-bone unit in the rat model of post-traumatic osteoarthritis

Biomechanical assessment of disease outcome in surgical intervention for medial meniscal posterior root tears: efficacy and considerations

Post-traumatic osteoarthritis: epidemiology, pathogenesis, clinical picture, approaches to pharmacotherapy

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