Post-traumatic Neuroinflammation: Relevance to Pediatrics

Ashwal, Stephen; Siebold, Lorraine; Krueger, Amy C.; Wilson, Christopher G.

doi:10.1016/j.pediatrneurol.2021.04.010

Cited by 1 publication

(1 citation statement)

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“…Importantly, attention needs to be directed toward pediatric populations as well, as childhood and adolescence is a time of elevated risk for TBI [52], and prognosis and treatment responses may differ from adults due to the neuronal and brain network developmental status [53,54]. For instance, TBI can influence hippocampal neuro-genesis, which can increase the risk of developing adult neurological and neurodegenerative diseases [55,56].…”

Section: Tbi and Neuroinflammationmentioning

confidence: 99%

The Putative Role of Neuroinflammation in the Interaction between Traumatic Brain Injuries, Sleep, Pain and Other Neuropsychiatric Outcomes: A State-of-the-Art Review

Babiloni

Baril

Charlebois-Plante

et al. 2023

JCM

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Sleep disturbances are widely prevalent following a traumatic brain injury (TBI) and have the potential to contribute to numerous post-traumatic physiological, psychological, and cognitive difficulties developing chronically, including chronic pain. An important pathophysiological mechanism involved in the recovery of TBI is neuroinflammation, which leads to many downstream consequences. While neuroinflammation is a process that can be both beneficial and detrimental to individuals’ recovery after sustaining a TBI, recent evidence suggests that neuroinflammation may worsen outcomes in traumatically injured patients, as well as exacerbate the deleterious consequences of sleep disturbances. Additionally, a bidirectional relationship between neuroinflammation and sleep has been described, where neuroinflammation plays a role in sleep regulation and, in turn, poor sleep promotes neuroinflammation. Given the complexity of this interplay, this review aims to clarify the role of neuroinflammation in the relationship between sleep and TBI, with an emphasis on long-term outcomes such as pain, mood disorders, cognitive dysfunctions, and elevated risk of Alzheimer’s disease and dementia. In addition, some management strategies and novel treatment targeting sleep and neuroinflammation will be discussed in order to establish an effective approach to mitigate long-term outcomes after TBI.

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Section: Tbi and Neuroinflammationmentioning

confidence: 99%