Post-traumatic knee osteoarthritis; the role of inflammation and hemarthrosis on disease progression

Evers, Bob J.; Bosch, M.H. van den; Blom, A.B.; Kraan, P.M. van der; Koëter, Sander; Thurlings, Rogier M.

doi:10.3389/fmed.2022.973870

Cited by 21 publications

(20 citation statements)

References 164 publications

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“…Synovial cells release inflammatory cytokines such inter leukines (IL)-1, IL-4, IL-6, IL-8, IL-10, IL-17, and tumour necrosis factor, which are present in higher amounts in injured joints, as a result of this binding activating downstream signalling cascades. Inflammatory chemokines, cathepsins, and complement cascade components are also produced by synovial cells (8).…”

Section: Explanation Of Inflammation Process From Literaturementioning

confidence: 99%

Inflammation Process, Outcome and Prevention of Post-Traumatic Osteoarthritis

Sunbol¹,

aldahan²,

Mubarak³

et al. 2023

JOHS

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Osteoarthritis is a prominent cause of disability with rising prevalence and incidence. An essential risk factor for posttraumatic osteoarthritis, joint injury history has a substantial role in the rapidly rising prevalence of osteoarthritis in the general population. A prolonged trauma associated with recurring instability leads to the development of posttraumatic osteoarthritis, which commonly affects the knee and ankle joints. Due to the high number of knee and ankle injuries that occur each year and the strong association between joint damage and the development of osteoarthritis, posttraumatic osteoarthritis represents a significant public health burden. The onset of the chronic disease seems to be significantly influenced by the activation of inflammatory pathways during the posttraumatic osteoarthritis acute phase. Immediately following joint trauma, a number of inflammatory mediators are secreted in synovial fluid. These inflammatory mediators are the predictors of the disease. The purpose of this research is to review the available information about inflammation process, outcome and prevention of post-traumatic osteoarthritis. The continued activation of innate inflammatory pathways may contribute to the maintenance of inflammation and the development of posttraumatic osteoarthritis in the injured joint. Various studies reported more complications observed in posttraumatic osteoarthritis patients as compared to others after knee arthroplasties. Prevention of posttraumatic osteoarthritis shall be targeted before the initiation of clinical onset of posttraumatic osteoarthritis. Anti-inflammatory drugs with sustained delivery can be more beneficial in prevention of cartilage degeneration although further research is needed to study and develop preventive strategies for posttraumatic osteoarthritis.

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Section: Explanation Of Inflammation Process From Literaturementioning

confidence: 99%

Inflammation Process, Outcome and Prevention of Post-Traumatic Osteoarthritis

Sunbol¹,

aldahan²,

Mubarak³

et al. 2023

JOHS

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“…Тканевое повреждение сопровождается появлением огромного количества клеточных метаболитов и «обломков» структурных белков («молекулярного комплекса повреждения», DAMP), являющихся мощным стимулом для развития воспалительной реакции. Активация воспаления происходит в первую очередь за счет стимуляции резидентных макрофагов и синовиальных фибробластов -носителей толл-подобных рецепторов (TLR), лигандом которых выступают компоненты DAMP [13][14][15].…”

Section: патогенезunclassified

“…Атака протеолитических ферментов, гипоксия и перекисные процессы способны менять антигенную структуру белковых макромолекул (в частности, коллагена и эластина), вызывая активацию Т-и В-лимфоцитов и локальные им-мунные реакции. Воспаление также приводит к усиленной дифференциации остеокластов (процесс, индуцируемый ФНОα через ось RANKL/RANK) и разрушению субхондральной кости [13][14][15].…”

Section: патогенезunclassified

Post-traumatic osteoarthritis: epidemiology, pathogenesis, clinical picture, approaches to pharmacotherapy

Karateev¹,

Chernikova²,

Макаров³

2023

Sovremennaâ revmatologiâ

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Post-traumatic osteoarthritis (PTOA) is an inflammatory and degenerative disease that occurs as a result of the joint structures injury. It is a common pathology, accounting for approximately 12% of all cases of osteoarthritis (OA). PTOA often occurs in people of young productive age, progresses rapidly, causing chronic pain and increasing dysfunction. Individuals undergoing joint replacement for PTOA are, on average, 10 years younger than those with primary OA. The time interval from the moment of injury to the onset of typical PTOA radiological signs varies widely – from 1 year to 15–20 years.The main injuries that cause PTOA are intra-articular fractures, anterior cruciate ligament injuries, meniscus rupture and dislocation of the patella of the knee joint, joint dislocations with damage to the ligamentous apparatus of the ankle and shoulder joints.The pathogenesis of PTOA is determined by chronic inflammation accompanied by macrophage activation, hyperproduction of cytokines, primarily interleukin (IL) 1â, chemokines and growth factors, progressive destruction of joint tissue and degenerative changes (fibrosis, neoangiogenesis, osteophytosis).Pathogenetic treatment of PTOA, which would stop the progression of the disease, has not been developed. The possibility of using inhibitors of IL1â, IL6, inhibitors of tumor necrosis factor á, glucocorticoids, hyaluronic acid, autologous cell based therapy is under study. The control of pain and inflammation in PTOA requires the prescription of traditional drugs that are widely used in the practice of managing patients with primary OA. In particular, the use of symptomatic delayed-acting agents, such as the injectable form of chondroitin sulfate, seems to be appropriate.

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“…Острые травмы приводят к серьезным страданиям, утрате функции и трудоспособности, представляя большую медицинскую и социальную проблему. Не менее сложной задачей, стоящей перед медицинской наукой, являются профилактика и лечение отдаленных последствий травм, таких как хроническая посттравматическая боль (ХПТБ) и пост травматический (ПТ) остеоартрит (ОА) [9][10][11].…”

Section: Factors Determining the Development Of Post-traumatic Pain A...unclassified

Factors determining the development of post-traumatic pain and post-traumatic osteoarthritis

Chernikova,

Karateev,

Makarov

et al. 2023

Naučno-praktičeskaâ revmatologiâ

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Injuries cause a systemic neurohumoral and behavioral response of the body, aimed at restoring damaged tissues and correcting biomechanical disorders. However, in many cases, full-fledged repair is impossible – traumatic injury, inflammation that occurs against its background, and degenerative processes (fibrosis, neoangiogenesis, heterotopic ossification) lead to severe structural changes and a progressive decrease in functional ability. The most common complications of trauma include chronic post-traumatic pain and post-traumatic osteoarthritis (PTOA). These complications are interrelated – pain (accompanied by stiffness and dysfunction) that occurs in 10–50% of people who have suffered a joint injury may indicate the formation of early (pre-radiological) stages of PTOA. The development of typical structural changes in PTOA is observed 10–15 years after a knee injury (in >30% of patients). PTOA of large joints is more aggressive, often accompanied by synovitis, and requires arthroplasty on average 10–15 years earlier than primary osteoarthritis. Early diagnosis of PTOA is based on the analysis of the dynamics of clinical manifestations (primarily post-traumatic pain), visualization of early changes in the structure of the joint (magnetic resonance imaging), as well as the study of the level of biomarkers of inflammation and osteochondral destruction. As additional risk factors for PTOA, genetic features are considered that determine the chronicity of inflammation, pain, and impaired repair of cartilage and bone tissue.

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Post-traumatic knee osteoarthritis; the role of inflammation and hemarthrosis on disease progression

Cited by 21 publications

References 164 publications

Inflammation Process, Outcome and Prevention of Post-Traumatic Osteoarthritis

Inflammation Process, Outcome and Prevention of Post-Traumatic Osteoarthritis

Post-traumatic osteoarthritis: epidemiology, pathogenesis, clinical picture, approaches to pharmacotherapy

Factors determining the development of post-traumatic pain and post-traumatic osteoarthritis

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