Post-traumatic glioma: Report of one case and review of the literature

Abstract

We report one case of brain glioma that developed in the scar of an old brain trauma. A 45-year-old man who presented with seizures; MRI showed a large mass in the right temporal region. Surgical biopsy showed a glioblastoma multiforme. The patient had suffered a cranial trauma in a road accident 10 years previously with an intracerebral hematoma in the right temporal region. This case fulfills the established criteria for a traumatic origin of brain tumors and adds further support to the relationship between cranial trauma and the onset of glioma. As stated by other authors, an association between head trauma and brain tumor risk cannot be ruled out and should be studied further.

Risk factors for gliomas. An extensive review

“…In a Danish cohort study, that included patients hospitalized for concussion, fractured skull or any other head trauma, the incidence of gliomas was the same as for the general population (131). Several authors reported cases that indicated head trauma as the cause of gliomas and its influence needs to be further investigated (132).…”

Posttraumatic Glioma: Report of a Case

“…For a long time, head injury has been considered as a possible causative factor for later development of brain tumors [1]. However, the actual role of previous head trauma in the pathogenesis of intracranial tumors is still a matter of debate [1], also due to the possible medico-legal implications [2].…”

Post Traumatic Glioma – An association questioned

“…With the routine use of CT and MRI, some of the pathologic criteria can be replaced or supplemented by imaging criteria. CT/MRI, which elegantly reveal the severity and location of the traumatic brain injury and the subsequent formation of a neoplasm at the same site, can provide convincing evidence for the traumatic causation of a brain tumor [6].…”