Post-traumatic factors are involved in the evolution of the number of seizures in patients with PNES

Grenevald, Louise; Gagny, Marion; Maillard, Louis; Chrusciel, Jan; Sanche, Stéphane; Schwan, Raymund; Klemina, Irina; Biberon, Julien; Toffol, Bertrand de; Thiriaux, Anne; Visseaux, Jean François; Martin, Martine Lemeles; Meyer, M.P.H. Roger J.; El‐Hage, Wissam; Hingray, Coraline

doi:10.1016/j.yebeh.2020.107544

Cited by 5 publications

(4 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(15) ( 16) By identifying certain traumatic factors, for example, we can predict the course of seizure frequency. (17) The psychiatrist has also an important role in case of comorbidity between PNES and epilepsy as we demonstrated later in this article.…”

Section: Some Pragmatic Keys…mentioning

confidence: 76%

Working toward the ideal situation: A pragmatic Epi-Psy approach for the diagnosis and treatment of psychogenic nonepileptic seizures

Hingray

Ertan

El‐Hage

et al. 2021

Epilepsy & Behavior

Self Cite

View full text Add to dashboard Cite

Section: Some Pragmatic Keys…mentioning

confidence: 76%

Working toward the ideal situation: A pragmatic Epi-Psy approach for the diagnosis and treatment of psychogenic nonepileptic seizures

Hingray

Ertan

El‐Hage

et al. 2021

Epilepsy & Behavior

Self Cite

View full text Add to dashboard Cite

“…Particularly with PNES, which is a disorder in which patients often report a sense of diminished self-control due to the erratic and unexpected nature of seizures, diminished control beliefs associated with depression might have a compounding effect on this sense. Furthermore, it is understood that depressive cognitive distortions can lead to impaired self-appraisals and less effective problem-solving [26][27][28] which could impact the decision to pursue reinstatement of driving privileges. In contrast, a more realistic view of one's resources combined with a sense of agency is often associated with resilience and general psychological wellbeing [23] which might support resumption of driving.…”

Section: Discussionmentioning

confidence: 99%

“…This was surprising as lower PTSD symptomatology could be thought to correlate positively with recovery (seizure-freedom). However, a recent study revealed that a diagnosis of PTSD was, in fact, associated with a reduction in the number of seizures at follow up [28]. The authors of that study speculated that this might be so because the association between the diagnosis of PTSD and PNES may be easier for the patients to understand and there are tailored treatments for PTSD which can result in recovery.…”

Section: Discussionmentioning

confidence: 99%

Characteristics of Patients Diagnosed with Psychogenic Non-Epileptic Seizures (PNES) Who Request Reinstatement of Their Driving Privileges

2024

J Psychiatry Cogn Behav

View full text Add to dashboard Cite

Objective: To compare patients with psychogenic non-epileptic seizures (PNES) who requested reinstatement of driving privileges or reported having resumed driving to those who did not. Methods: Diagnosis of PNES was confirmed with video-EEG. Demographic and clinical data and requests for reinstatement of driving privileges (requiring 6 or more months seizure freedom) and reports of decisions to resume driving were noted. Self-report questionnaires of depression, anxiety and PTSD that were administered as part of neuropsychological assessment were analyzed. Results: Of 73 patients with PNES evaluated in 2018-2021, 22 later applied for driving privileges or reported that they resumed driving. When the two groups were compared, the group that applied for driving privileges or decided to resume driving was determined to be significantly less depressed (p = 0.014) when initially assessed than the group that did not. Conclusion: Resumption of driving behavior is an explicit measure of improvement for PNES because patients are advised to discontinue driving until they are seizure-free for a determined time span. Findings revealed that initial lower experienced levels of depression symptoms were associated with subsequent reported seizure-freedom which allowed for the reactivation of driving privileges. This underscores the importance that depression may have on PNES prognosis and supports assessing and treating comorbid mood symptoms in a timely manner.

show abstract

“…The most recently published studies presented by French investigators were also strictly prospective. However, direct comparisons between baseline and follow‐up data were not presented, because they focused on the evolution of seizure frequency 51 or QoL 14 . Additionally, a prospective study of child patients published recently, which included cases of possible PNES as in this study, adopted attack frequency as the sole measure of PNES outcome 50 .…”

Section: Discussionmentioning

confidence: 99%

Prospective multicenter cohort study of possible psychogenic nonepileptic seizure cases—Results at 1‐year follow‐up examinations

et al. 2023

View full text Add to dashboard Cite

Objective: The primary purpose of this prospective multicenter study was to examine clinical and demographic feature differences according to the diagnostic level of psychogenic nonepileptic seizures (PNES) and then clarify whether prognosis may also differ accordingly.Methods: Two hundred forty-two consecutive patients strongly suspected of having PNES attacks were invited to participate, of whom 52 did not consent or contact was lost. At the 1-year follow-up examination, PNES diagnosis was reconsidered in nine patients. In 96 patients, the diagnostic level remained the same (P-group), with that in 43 considered to be clinically established (CEgroup) and in 42 documented (D-group). The Qolie-10 and NDDI-E questionnaires were examined at both the study entry and the follow-up examination.Results: Multiple regression analysis of quality of life (QoL) score (n = 173; R 2 = 0.374; F = 7.349; P < 0.001) revealed NDDI-E score (t = −6.402; P < 0.001), age of PNES onset (t = −3.026; P = 0.003), and ethnic minority status (t = 3.068; P = 0.003) as significant contributors. At entry, the P-group showed the lowest PNES attack frequency (P < 0.000), the lowest rate of antiseizure, antidepressant, and antipsychotic medication (P < 0.000; P = 0.031; P = 0.013, respectively), and the lowest proportion of psychosis (P = 0.046). At follow-up, PNES attack frequency (P < 0.000), number of admittances to emergency room (P < 0.000), and scores for QoL (P < 0.000) as well as depression (P = 0.004) were found to be significantly improved together with other collateral indicators, such as rate of antiseizure medication prescription (P = 0.001) and psychiatric symptoms (P = 0.03).Multiple regression analysis of a sample limited to patients with intellectual disability (ID) (n = 44; R 2 = 0.366; F = 4.493; P = 0.002) revealed continued psychotherapy at follow-up (t = 2.610, P = 0.013) and successful reduction in antiseizure medication (t = 2.868; P = 0.007) as positively related with improved QoL.

show abstract

Post-traumatic factors are involved in the evolution of the number of seizures in patients with PNES

Cited by 5 publications

References 17 publications

Working toward the ideal situation: A pragmatic Epi-Psy approach for the diagnosis and treatment of psychogenic nonepileptic seizures

Working toward the ideal situation: A pragmatic Epi-Psy approach for the diagnosis and treatment of psychogenic nonepileptic seizures

Characteristics of Patients Diagnosed with Psychogenic Non-Epileptic Seizures (PNES) Who Request Reinstatement of Their Driving Privileges

Prospective multicenter cohort study of possible psychogenic nonepileptic seizure cases—Results at 1‐year follow‐up examinations

Contact Info

Product

Resources

About