Post-traumatic amnesia

Marshman, Laurence A.G.; Jakabek, David; Hennessy, Maria; Quirk, Frances; Guazzo, E.

doi:10.1016/j.jocn.2012.11.022

Cited by 81 publications

(56 citation statements)

References 52 publications

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“…One other potential limitation is the effect of medication on the results. PTA patients are often under the influence of opioids or anticonvulsants, medications that may impair cognitive function (Marshman et al , 2013). In addition, different medications can affect the MRI signal, through alterations in vascular reactivity or neuronal activity (Wise and Tracey, 2006).…”

Section: Discussionmentioning

confidence: 99%

“…The WPTAS is a 12-item scale, with seven items that assess orientation and five items that assess memory. The PAL was preferred as the key PTA classification tool due to the concerns over the validity of the WPTAS in a research context (Marshman et al , 2013). The PAL is: (i) sensitive to memory impairments associated with hippocampal damage (Swainson et al , 2001); and (ii) provides a more detailed and graded assessment of associative memory and learning in comparison to the WPTAS.…”

Section: Methodsmentioning

confidence: 99%

“…Post-traumatic amnesia (PTA) frequently follows traumatic brain injury (TBI) and is characterized by transient anterograde amnesia, confusion, disorientation and agitation (Marshman et al , 2013). Together with attentional deficits, the inability to encode new memories is at the core of the syndrome, which has a highly variable duration lasting between seconds and months (Ahmed et al , 2000).…”

Section: Introductionmentioning

confidence: 99%

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Disconnection between the default mode network and medial temporal lobes in post-traumatic amnesia

Simoni

Grover

Jenkins

et al. 2016

Brain

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See Bigler (doi:) for a scientific commentary on this article.Post-traumatic amnesia is common following traumatic brain injury and is an important predictor of clinical outcome. De Simoni et al. report that post-traumatic amnesia results from a temporary disruption to functional brain networks involved in memory processing, with functional connectivity between the parahippocampal gyrus and posterior cingulate cortex particularly affected.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Disconnection between the default mode network and medial temporal lobes in post-traumatic amnesia

Simoni

Grover

Jenkins

et al. 2016

Brain

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“…Upon transfer to the inpatient neurorehabilitation unit, he remained in post-traumatic amnesia [20] and continued to have severe sleepwake disturbance and bouts of agitation. In the day he required one-toone nursing care and constant distraction through engagement with a variety of activities.…”

Section: Casementioning

confidence: 99%

Neuropsychiatric Complexities in the HIV Patient – Clinical Challenges beyond Neurocognitive Disorders

Sim¹,

Chan²

2017

J AIDS Clin Res

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Objective: To illustrate clinical challenges, explore existing literature and identify knowledge gaps in the management of neuropsychiatric issues beyond neurocognitive disorders in HIV patients. Methods:Three case vignettes from a consultation-liaison psychiatry setting in a general hospital were collated and summarised into a case series. Clinical questions were identified from each vignette and pertinent literature reviewed to aid a further discussion of management issues. Results:The first case vignette discusses the potential of a multi-dimensional approach to the formulation of a HIV patient with emergent psychiatric and cognitive symptoms. In the second, pharmacological treatment of a HIV patient with a severe manic relapse of Bipolar 1 Disorder and active TB disease is discussed. Lastly, the collective effects of severe Traumatic Brain Injury (TBI) and HIV infection superimposed on that of an ageing brain are described. Iatrogenic risks of polypharmacy in an elderly HIV patient are further explored. Conclusion:The practical aspects of clinical challenges regarding the management of HIV patients are multi-fold and most apparent in a real-world setting. Existing literature does not yet adequately address the diagnostic dilemmas and pharmacological complexities faced. The management of other neuropsychiatric manifestations in a HIV patient remains a crucial field to be explored.

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“…The term post traumatic amnesia has therefore become established to describe the constellation of cognitive and behavioural changes that occur at this stage of recovery. 12,13 A wide variety of figures (11-70%) 2 have been reported regarding the frequency of agitation during post traumatic amnesia. The timeframe for these early cognitive and behavioural changes varies from minutes to weeks after the traumatic brain injury.…”

Section: Introductionmentioning

confidence: 99%

Behavioural problems in the first year after Severe traumatic brain injury: a prospective multicentre study

et al. 2016

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Objective: To investigate the occurrence of behavioural problems in patients with severe traumatic brain injury during the first year after injury and potential associations with outcome. An additional post hoc objective was to analyse the frequency of behaviours with need for intervention from staff. Design and setting: In a prospective population based cohort study 114 patients with severe traumatic brain injury were assessed at three weeks, three months and one year after injury. Main measures: Assessments included clinical examination and standardised instruments. Agitation was assessed with the Agitated Behaviour Scale, the course of recovery by the Rancho Los Amigo Scale and outcome by Glasgow Outcome Scale Extended. Results: Agitation were most common at 3 weeks post injury and 28% (n=68) of the patients showed at least one agitated behaviour requiring intervention from staff. Presence of significant agitation at 3 weeks after injury was not associated with poor outcome. At 3 months agitation was present in 11% (n=90) and apathy in 26 out of 81 assessed patients. At 3 months agitation and apathy were associated with poor outcome at one year. Conclusions: Most agitated behaviours in the early phase are transient and are not associated with poor outcome. Agitation and apathy are uncommon at three months but when present are associated with poor outcome at one year after injury. In the early phase after a severe traumatic brain injury agitated behaviour in need of interventions from staff occur in a substantial proportion of patients.

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Post-traumatic amnesia

Cited by 81 publications

References 52 publications

Disconnection between the default mode network and medial temporal lobes in post-traumatic amnesia

Disconnection between the default mode network and medial temporal lobes in post-traumatic amnesia

Neuropsychiatric Complexities in the HIV Patient – Clinical Challenges beyond Neurocognitive Disorders

Behavioural problems in the first year after Severe traumatic brain injury: a prospective multicentre study

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