Post-transplant survival in idiopathic pulmonary fibrosis patients concurrently listed for single and double lung transplantation

Chauhan, Dhaval; Karanam, Ashwin; Merlo, Álvaro Roberto Crespo; Bozzay, PA Tom; Zucker, Mark; Seethamraju, Harish; Shariati, Nazly; Russo, Mark J.

doi:10.1016/j.healun.2015.12.030

Cited by 42 publications

(28 citation statements)

References 10 publications

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“…Moreover, 24% of this cohort underwent SLTx, also emphasizing the broad inclusion period, since this procedure has recently become obsolete in our and many other centers. Research on the outcome of SLTx in comparison with SSLTx showed conflicting results . However, in our cohort no significant impact of procedure type on post‐transplant outcome was seen, which was probably due to a correlation between type and year of transplantation.…”

Section: Discussioncontrasting

confidence: 73%

Outcome of lung transplantation in non‐idiopathic pulmonary fibrosis interstitial lung disease

Bode¹,

Verleden

Wuyts

et al. 2019

Clinical Transplantation

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Lung transplantation remains the only curative treatment option for selected patients with end-stage interstitial lung disease (ILD). Candidate selection is impeded by patient heterogeneity, particularly in the subgroup of non-idiopathic pulmonary fibrosis (non-IPF) interstitial lung diseases. We performed a descriptive analysis of all non-IPF ILD patients who underwent lung transplantation in our center between July 1991 and November 2016 (n = 129) and searched for pre-transplant variables correlating with graft loss and chronic lung allograft dysfunction (CLAD). Our study cohort was characterized by a significantly affected medical condition, an extensive pre-transplant corticosteroid use (73.8%), and a high prevalence of pulmonary hypertension (55.7%). Earlier year of transplantation (P = .004), higher bilirubin level (P < .0001), older recipient age (P = .04), and smaller recipient height (P = .02) were found to be associated with earlier graft loss in multivariate analysis. Moreover, pre-transplant corticosteroid treatment tended to be related to earlier graft loss (P = .06), while pulmonary hypertension did not significantly correlate. None of the pre-transplant variables were shown to be associated with CLAD development. Ongoing research is required to further explore this diverse patient population and the pre-transplant variables determining their post-transplant outcome.

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Section: Discussioncontrasting

confidence: 73%

Outcome of lung transplantation in non‐idiopathic pulmonary fibrosis interstitial lung disease

Bode¹,

Verleden

Wuyts

et al. 2019

Clinical Transplantation

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“…However controversy regarding the ideal procedure for IPF lung transplant recipients is based on conflicting reports regarding whether double lung transplant (DLT) offers a survival advantage over single lung transplant (SLT). [1][2][3][4][5][6][7][8][9] Most recently a report suggested that DLT should be the "procedure of choice" for pulmonary fibrosis patients younger than 70 years of age, especially in patients with high lung allocation scores (LAS). 9 However a significant number of IPF recipients treated with SLT remain, indicating that the lung transplant community still collectively believes SLT is an appropriate or the only option for some proportion of IPF recipients.…”

mentioning

confidence: 99%

Single and Double Lung Transplantation Have Equivalent Survival for Idiopathic Pulmonary Fibrosis

Ranganath

Malas

Phillips

et al. 2020

The Annals of Thoracic Surgery

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“…To date, no randomized controlled studies have weighed the superiority of SLT to BLT in patients with IPF. We compared the data collected at our centre with those published in other countries 10,11,[15][16][17][18][19][20][21][22] (Table 4). Weiss ES and his colleagues reviewed 1256 patients with pulmonary fibrosis and identified that BLT was associated with a lower risk of mortality at 1 year for those with highest LAS.…”

Section: Discussionmentioning

confidence: 99%

Single versus bilateral lung transplantation for idiopathic pulmonary fibrosis

Dong

Gao

et al. 2019

Clinical Respiratory J

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Background Lung transplantation, either single or bilateral, serves as the only effective treatment for end‐stage idiopathic pulmonary fibrosis (IPF), but their superiority is still being debated, and its application in Chinese patients has not been data analysed. Methods We reviewed 109 IPF patients who received lung transplantation at our centre between January 1, 2015 and December 31, 2017. The patients were divided into single lung transplantation (SLT) group and bilateral lung transplantation (BLT) group. We compared the two groups’ demographic characteristics and clinical indexes (intraoperative conditions, postoperative complications, follow‐ups and life qualities). Results Patients in BLT group were significantly younger than those in SLT group (P < 0.001), and had more pretransplant infections (P = 0.007). The total ischemic time (P < 0.001) was shorter and intraoperative blood loss was less (P = 0.001) in SLT group. No significant difference was found in the proportion of patients in using anti‐fibrosis drugs, pulmonary artery pressure, extracorporeal membrane oxygenation during the surgery; the length of intensive care unit stay; the incidence of complication; and the overall survival rate between two groups. However, the hierarchical analysis found that patients aged > 60 years showed a better survival in SLT group (P = 0.008). Both groups got normal MOS 36‐item Short Form (SF‐36) scores, and the scores of BLT were higher than those of SLT. The BLT group had better lung function than SLT group 1 year post‐lung transplantation. Conclusions Both SLT and BLT are effective and SLT is more favourable for the patients of > 60 years.

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Post-transplant survival in idiopathic pulmonary fibrosis patients concurrently listed for single and double lung transplantation

Cited by 42 publications

References 10 publications

Outcome of lung transplantation in non‐idiopathic pulmonary fibrosis interstitial lung disease

Outcome of lung transplantation in non‐idiopathic pulmonary fibrosis interstitial lung disease

Single and Double Lung Transplantation Have Equivalent Survival for Idiopathic Pulmonary Fibrosis

Single versus bilateral lung transplantation for idiopathic pulmonary fibrosis

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