Post-transplant nuclear renal scans correlate with renal injury biomarkers and early allograft outcomes

Obeidat, Motaz; Luyckx, Valérie A.; Grebe, Scott O.; Jhangri, Gian S.; Maguire, Connor; Zavodni, Anna; Jackson, Stuart; Mueller, Thomas

doi:10.1093/ndt/gfq814

Cited by 19 publications

(5 citation statements)

References 53 publications

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“…Differentiating between AR and ATN is important though challenging since AR will result in permanent damage if left untreated. Additionally, complicated by the fact that both entities can be present at the same time (Table 2) [20]. In case of both AR and ATN, the perfusion, uptake, parenchymal transit, and excretion of the renal transplant are all impaired.…”

Section: Differentiating Acute Rejection From Acute Tubular Necrosismentioning

confidence: 99%

Renal scintigraphy for post-transplant monitoring after kidney transplantation

Benjamens

Berger

Glaudemans

et al. 2018

Transplantation Reviews

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Several studies have described the use of RS for the diagnosis of acute rejection, however, differentiating between rejection and acute tubular necrosis remains difficult. For the diagnosis of vascular complications, RS has been described as an alternative for invasive procedures. For urologic complications, studies support the use of RS in combination with routine ultrasonography (US) surveillance. For the diagnosis of postoperative fluid collections, RS provides information to differentiate lymphoceles and urinomas. Altogether, RS should be considered in case of non-acute complications, and if US provides insufficient results.

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Section: Differentiating Acute Rejection From Acute Tubular Necrosismentioning

confidence: 99%

Renal scintigraphy for post-transplant monitoring after kidney transplantation

Benjamens

Berger

Glaudemans

et al. 2018

Transplantation Reviews

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“…A great deal of research has been done to identify markers of acute kidney injury (31,70,86,103), and, as a result, the measurement of kidney damage has moved well beyond assay Fig. 8.…”

Section: Biomarkers Of Kidney Damagementioning

confidence: 99%

Severe acute dehydration in a desert rodent elicits a transcriptional response that effectively prevents kidney injury

MacManes

2017

American Journal of Physiology-Renal Physiology

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Animals living in desert environments are forced to survive despite severe heat, intense solar radiation, and both acute and chronic dehydration. These animals have evolved phenotypes that effectively address these environmental stressors. To begin to understand the ways in which the desert-adapted rodent survives, reproductively mature adults were subjected to 72 h of water deprivation, during which they lost, on average, 23% of their body weight. The animals reacted via a series of changes in the kidney, which included modulating expression of genes responsible for reducing the rate of transcription and maintaining water and salt balance. Extracellular matrix turnover appeared to be decreased, and apoptosis was limited. In contrast to the canonical human response, serum creatinine and other biomarkers of kidney injury were not elevated, suggesting that changes in gene expression related to acute dehydration may effectively prohibit widespread kidney damage in the cactus mouse.

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“…A great deal of research has gone into identifying markers of acute kidney injury (1,(98)(99)(100) , and as a result, the measurement of kidney damage has moved well beyond assaying serum Creatinine, which is known to be relatively insensitive and slow to indicate damage (101) . In humans, dehydration and other clinical conditions that cause a pathological reduction in renal perfusion pressure are responsible for acute kidney injury (102) .…”

Section: Biomarkers Of Kidney Damagementioning

confidence: 99%

Severe acute dehydration in a desert rodent elicits a transcriptional response that effectively prevents kidney injury

Matthew

2017

Preprint

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Animal living in desert environments are forced to survive despite severe heat, intense solar radiation, and both acute and chronic dehydration. Indeed, these animals have evolved phenotypes that effectively address these environmental stressors. To begin to understand the ways in which the desert adapted rodent P. eremicus survives, we performed an experiment by which we subjected reproductively mature adults to profound acute dehydration, during which they lost on average 23% of their body weight. Animals react via a series of changes in the kidney, which include modulating expression of genes responsible for reducing the rate of transcription, and maintaining water and salt balance. Extracellular matrix turnover appears to be decreased, and apoptosis is limited. Serum Creatinine and other biomarkers of kidney injury are not elevated, which is different than the canonical human response, suggesting that transcriptional changes caused by acute dehydration effectively prohibit widespread kidney damage in the cactus mouse.

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Post-transplant nuclear renal scans correlate with renal injury biomarkers and early allograft outcomes

Cited by 19 publications

References 53 publications

Renal scintigraphy for post-transplant monitoring after kidney transplantation

Renal scintigraphy for post-transplant monitoring after kidney transplantation

Severe acute dehydration in a desert rodent elicits a transcriptional response that effectively prevents kidney injury

Severe acute dehydration in a desert rodent elicits a transcriptional response that effectively prevents kidney injury

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