Post-transplant increase in soluble human leukocyte antigen-G associated with non-severe cardiac allograft vasculopathy

Blanco-García, R.M.; López-Álvarez, María R.; Garrido, Iris P.; Salgado-Cecilia, G.; Campillo, José A.; Bolarín, José Miguel; Gimeno, L.; Muro, Manuel; García‐Alonso, Ana M.; Martínez‐Sánchez, María V.; Pisa, M.V. Bernardo; Soriano-Díaz, S.; Pascual-Figal, Domingo A.; Álvarez-López, María R.; Minguela, Alfredo

doi:10.1016/j.humimm.2012.12.001

Cited by 10 publications

(5 citation statements)

References 39 publications

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“…Regarding the source of sHLA-G, one in vitro study gives hints that during an allogeneic reaction HLA-G5 is released by allospecific CD4(+) T cells, resulting in the suppression of the proliferative T cell response [98]. Controversial results have been reported for cardiac allograft vasculopathy (CAV), which is a major limitation of long-term survival after heart transplantation: in one study sHLA-G levels have been found to be increased in recipients without heart allograft CAV compared to recipients suffering from severe CAV post transplantation [99], whereas the another one could not observe any differences between these two patients groups [100]. …”

Section: Hla-g and Transplantationmentioning

confidence: 99%

HLA-G as a Tolerogenic Molecule in Transplantation and Pregnancy

Rebmann

Nardi

Wagner

et al. 2014

Journal of Immunology Research

101

113

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HLA-G is a nonclassical HLA class I molecule. In allogeneic situations such as pregnancy or allograft transplantation, the expression of HLA-G has been related to a better acceptance of the fetus or the allograft. Thus, it seems that HLA-G is crucially involved in mechanisms shaping an allogeneic immune response into tolerance. In this contribution we focus on (i) how HLA-G is involved in transplantation and human reproduction, (ii) how HLA-G is regulated by genetic and microenvironmental factors, and (iii) how HLA-G can offer novel perspectives with respect to therapy.

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Section: Hla-g and Transplantationmentioning

confidence: 99%

HLA-G as a Tolerogenic Molecule in Transplantation and Pregnancy

Rebmann

Nardi

Wagner

et al. 2014

Journal of Immunology Research

101

113

View full text Add to dashboard Cite

show abstract

“…Anti-hnRNP-K antibodies Presence of anti-hnRNP-K antibodies was higher in the IVUS-defined CAV group (85.3%) and angiography-defined CAV patients (90.5%) than the non-CAV group (p < 0.0001 and p = 0.0023, respectively) Blanco-Garcia [61] (2013)…”

Section: Prognostic Value Of Biomarkers In Cardiac Allograft Vasculopmentioning

confidence: 94%

“…HLA-G has been shown to have inhibitory effects on T cells, natural killer cells, and dendritic cells, and mediates immune tolerance by inhibiting graft rejection [60]. A study from Blanco-Garcia et al [61] aimed to evaluate the role of soluble HLA-G (sHLA-G) in predicting the severity of CAV. The study revealed that patients with severe CAV had higher sHLA-G levels after transplantation.…”

Section: Serummentioning

confidence: 99%

Prognostic Value of Biomarkers in Cardiac Allograft Vasculopathy following Heart Transplantation: A Literature Review

et al. 2020

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Cardiac allograft vasculopathy (CAV), also known as cardiac transplant vasculopathy, is a major determinant of long-term survival among cardiac transplantation recipients. Histologically, CAV is featured by diffuse, concentric thickening of the vascular wall, and primarily affects large and small epicardial coronary arteries, intramyocardial arteries, and veins. Owing to graft denervation, CAV typically follows an insidious course, and patients may not experience classic angina symptoms but instead present with progressive heart failure or ventricular arrhythmias. Recent studies on biomarkers have furthered the knowledge concerning the prediction and prognosis of CAV. Given its association with metabolic, thrombotic, inflammatory, and immunologic markers, CAV is likely to represent a complex multifactorial process that involves both immune-mediated and non-immune-mediated pathways. In order to identify the high-risk patients that would benefit from early intervention, future research is warranted to examine the usefulness of a biomarker panel in CAV risk stratification.

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“…A higher sHLA-G pretransplant was associated with more infections in heart transplantation ( 139 ). Also patients with CAV and high HLA-G expression were at risk for CMV post heart transplantation ( 140 ). Therefore HLA-G polymorphisms might also be a predictive marker in infection risks.…”

Section: Transplantationmentioning

confidence: 99%

Biological Characteristics of HLA-G and Its Role in Solid Organ Transplantation

et al. 2022

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Organ transplantation is a lifesaving option for patients with advanced diseases. Rejection is regarded as one of the most severe risk factors post-transplantation. A molecule that contributes to immune tolerance and resisting rejection is human leukocyte antigen (HLA)-G, which belongs to the non-classical major histocompatibility complex class (MHC) I family. HLA-G was originally found to play a role during pregnancy to maintain immune tolerance between mother and child. It is expressed in the placenta and detected in several body fluids as soluble factor as well as different membrane isoforms on cells. Recent findings on HLA-G show that it can also play multifaceted roles during transplantation. This review will explain the general characteristics and biological function of HLA-G and summarize the views supporting the tolerogenic and other roles of HLA-G to better understand its role in solid organ transplantation (SOT) and its complications. Finally, we will discuss potential future research on the role of HLA-G in prevention, diagnosis, and treatment in SOT.

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Post-transplant increase in soluble human leukocyte antigen-G associated with non-severe cardiac allograft vasculopathy

Cited by 10 publications

References 39 publications

HLA-G as a Tolerogenic Molecule in Transplantation and Pregnancy

HLA-G as a Tolerogenic Molecule in Transplantation and Pregnancy

Prognostic Value of Biomarkers in Cardiac Allograft Vasculopathy following Heart Transplantation: A Literature Review

Biological Characteristics of HLA-G and Its Role in Solid Organ Transplantation

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