Post-Transplant Diabetes: Prevalence, Risk, and Management Challenges

Bashier, Alaaeldin; Kumar, Dileep; Alalawi, Fakhriya; Nour, Hind Al; Hadari, Amna Khalifa Al; Hussain, Azza Abdulaziz Bin

doi:10.1159/000522092

Cited by 5 publications

(3 citation statements)

References 97 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Up to 22.5 % of kidney transplant patients develop diabetes after the transplant [2] . Glycemic control in patients with diabetes post renal transplant is of paramount importance to maintain normal graft function [3] .…”

Section: Introductionmentioning

confidence: 99%

Safety and efficacy of semaglutide in post kidney transplant patients with type 2 diabetes or Post-Transplant diabetes

Mahzari,

Alluhayyan,

Almutairi

et al. 2024

Journal of Clinical & Translational Endocrinology

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Safety and efficacy of semaglutide in post kidney transplant patients with type 2 diabetes or Post-Transplant diabetes

Mahzari,

Alluhayyan,

Almutairi

et al. 2024

Journal of Clinical & Translational Endocrinology

View full text Add to dashboard Cite

“…Diabetic nephropathy remains the most common cause of end-stage kidney disease, 28 and KT can further aggravate existing diabetes or result in new-onset DM by chronic administration of immunosuppressant therapy. 29,30 Diabetic complications such as retinopathy and neuropathy are known to increase the risk of falls and fractures. 31,32 Particular attention to these populations is needed for the management of PTBD.…”

Section: Discussionmentioning

confidence: 99%

Association of physical activity with fractures in kidney transplant recipients: A Korean nationwide cohort study

Kim,

Jung,

Lee

et al. 2024

Clinical Transplantation

View full text Add to dashboard Cite

Kidney transplant recipients are at high risk for fractures, primarily due to post‐transplant bone disease. This retrospective cohort study analyzed data from the Korean National Health Insurance Service, including 10 083 kidney transplant recipients examined from 2009 to 2017. We assessed fracture incidence, emphasizing vertebral and hip fractures, and the association of physical activity and traditional risk factors with fracture risk. Kidney transplant recipients were categorized into three groups according to physical activity levels: non‐activity, metabolic equivalent of task (MET) 1–499, and MET ≥500. Physical activity was associated with a decreased risk of all types of fractures: any (MET 1–499: adjusted hazard ratio (aHR) .75; 95% confidence interval (CI) .62–.92, MET ≥500: aHR .84; 95% CI .70–1.00), vertebral (MET 1–499: aHR .69; 95% CI .49–.98, MET ≥500: aHR .67; 95% CI .49–.91), and hip (MET 1–499: aHR .43; 95% CI .23–.81) fractures. Additionally, older age, female sex, and diabetes were associated with an increased fracture risk. The assessment of physical activity and traditional risk factors could improve fracture risk prediction. Our findings emphasize the need for further research to establish optimal physical activity recommendations for fracture prevention in kidney transplant recipients.

show abstract

“…Importantly, nevertheless, cardiovascular disease is associated with higher morbidity and mortality in renal transplant recipients, and de novo post-transplant diabetes mellitus (PTDM) is considered a significant contributor to this adverse outcome. Diagnostic criteria for PTDM are based on fasting plasma sugar (≥7 mmol/L or ≥126 mg/dL), random plasma sugar (≥11.1 mmol/L or ≥200 mg/dL), and glycated haemoglobin (HBA1C: >6.5% or 48 mmol/mol) (Table 1) [2][3][4]; however, HBA1C in early post-operative period in renal disease patients can be affected by iron deficiency, blood loss, or blood transfusion; therefore, for PTDM screening, HBA1C should merely be used after 3 months of transplantation [5]. Early hyperglycaemia after surgery is quite common, and it may or may not be associated with long-term hyperglycaemia (PTDM).…”

Section: Introductionmentioning

confidence: 99%

Post-Transplant Diabetes Mellitus in Renal Transplant Recipients, Single-Centre Data: Incidence, Risk Factors, and Effect on Graft Function and Mortality

Kumar¹,

Gulzar²,

Alalawi³

et al. 2023

Dubai Diabetes Endocrinol J

View full text Add to dashboard Cite

Background: De novo post-transplant diabetes mellitus (PTDM) is a frequent complication among renal transplant recipients; it confers a high risk for graft failure and patient mortality. This single-centre study aimed to determine the incidence and risk factors of PTDM and its effects on graft outcome and mortality. Methods: In a single-centre longitudinal cohort analysis of 383 non-diabetic renal transplant follow-up recipients, outcomes were analysed through a detailed chart review. We hypothesized that different donor and recipient characters such as age, gender, and HLA mismatch would affect PTDM development in renal transplant recipients. PTDM is defined on basis of fasting plasma sugar (≥7 mmol/L or ≥126 mg/dL), random plasma sugar (≥11.1 mmol/L or ≥200 mg/dL), and glycated haemoglobin (HBA1C: >6.5% or 48 mmol/mol). We assessed PTDM incidence, risk factors, and its effect on patient mortality and graft outcome using Cox regression. Results: The mean age at the time of transplantation was 35.70 (±14.27) years, and 50.91% were male. PTDM incidence in the study period was 23.30%. Independent risk factors include older age at the time of transplantation, cyclosporine immunosuppression, cytomegalovirus, and hepatitis C virus infection. PTDM is not associated with graft dysfunction, whereas it significantly carries high mortality. Conclusion: PTDM is common among renal transplant recipients. Older age at the time of transplantation, cyclosporine immunosuppression, cytomegalovirus, and hepatitis C virus are risk factors. PTDM carries high mortality but is not associated with graft failure.

show abstract

Post-Transplant Diabetes: Prevalence, Risk, and Management Challenges

Cited by 5 publications

References 97 publications

Safety and efficacy of semaglutide in post kidney transplant patients with type 2 diabetes or Post-Transplant diabetes

Safety and efficacy of semaglutide in post kidney transplant patients with type 2 diabetes or Post-Transplant diabetes

Association of physical activity with fractures in kidney transplant recipients: A Korean nationwide cohort study

Post-Transplant Diabetes Mellitus in Renal Transplant Recipients, Single-Centre Data: Incidence, Risk Factors, and Effect on Graft Function and Mortality

Contact Info

Product

Resources

About