Abstract:matched sibling bone marrow transplantation results in approximately 85% event free survival in high-risk patients with Sickle Cell Disease (SCD) (Walters, NEJM, 2006). However, this approach is limited by 5-10% transplantrelated mortality, 5-10% primary graft failure and the late effects of Bu/CY. Alternate approaches include reduced toxicity but more immunosuppressive conditioning and the use of sibling cord blood (Geyer/Cairo, BJH, 2011 and Freed/ Cairo, BMT, 2012). Objective: To determine the safety, donor… Show more
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