Post‐translational modifications of protein in response to ionizing radiation

Abstract

Based on central dogma of genetics, protein is the embodiment and executor of genetic function, post-translational modifications (PTMs) of protein are particularly important and involved in almost all aspects of cell biology and pathogenesis. Studies have shown that ionizing radiation (IR) alters gene expression much more profoundly and a broad variety of cell-process pathways, lots of proteins are modified and activated. Our understanding of the protein in response to ionizing radiation is steadily increasing. Among the various biological processes known to induce radioresistance, PTMs have attracted marked attention in recent years. The present review summarizes the latest knowledge about how PTMs response to ionizing radiation and pathway analysis were conducted. The data provided insights into biological effects of IR and contributing to the development of novel IR-based strategies.

Ionizing Radiation Drives Key Regulators of Antigen Presentation and a Global Expansion of the Immunopeptidome

“…While radiation is known to induce certain modifications in the proteome, its effect on posttranslational modifications (PTMs) in the immunopeptidome are unknown (31). We first determined whether the inclusion of a PTM search criteria would alter the overall findings observed in the standard analysis.…”

Identification of the genetic central dogma in osteogenic differentiation of MSCs by osteoinductive medium from transcriptional data sets

“… 9 Detailly, the pathways such as DNA replication, Mismatch repair, Ribosome, Spliceosome, Aminoacyl‐tRNA biosynthesis, RNA transport, RNA degradation, and messenger RNA surveillance pathway are associated to GCD due to their participations in DNA–RNA–protein processes. 11 , 12 , 13 , 14 , 24 , 25 For example, the disfunction of ribosome and associated pathways, that is, the RNA transcription and protein translation, attributes to osteoarthritis. 14 In human cells, mechanical stress influences the rheology through the pathways related to DNA replication and repair.…”

Posttranslational control of lipogenesis in the tumor microenvironment

“…PTMs at specific amino acid residues of proteins are necessary for and mediate almost all dynamic processes within cellular signaling networks [96][97][98][99][100]. Protein PTMs include, but are not limited to, phosphorylation, acetylation, ubiquitination, SUMOylation, succinylation and methylation [99][100][101][102][103][104].…”

“…Protein PTMs include, but are not limited to, phosphorylation, acetylation, ubiquitination, SUMOylation, succinylation and methylation [99][100][101][102][103][104]. These alterations, which are often transient in nature, affect the structure, function, stability and localization of many proteins [96,100,105,106]. PTMs may be differ considerably between tumors and their normal tissue counterparts and often serve as driving forces for tumorigenesis [107][108][109][110].…”