“…However, markedly elevated amounts of acetaldehyde can be accumulated after inhibition of ALDH2 with its chemical inhibitors such as disulfiram (Antabuse ® ) and cyanamide. Alternatively, acetaldehyde can be elevated after suppression of mitochondrial ALDH2 through various forms of PTM following exposure to many hepatotoxic agents such as alcohol (Moon et al, 2006;Venkatraman, Landar, Davis, Ulasova, et al, 2004), APAP, high fat, anticancer drugs, toxic substances, and other pathological conditions, as reviewed (Song, Akbar, et al, 2014;Song et al, 2013Song et al, , 2011. In fact, accumulated NADH and acetaldehyde caused by using either disulfiram (Antabuse ® ) or cyanamide caused fat accumulation in alcohol-exposed hepatoma cells H4EIIE cells or rodents (Kato, Kawase, Alderman, Inatomi, & Lieber, 1990;You, Fischer, Deeg, & Crabb, 2002;You, Matsumoto, Pacold, Cho, & Crabb, 2004).…”