Post-transcriptional control by RNA-binding proteins in diabetes and its related complications

Zhang, Shiyu; Yang, Xiao-Hua; Jiang, Miao; Ma, Lianhua; Hu, Ji; Zhang, Honghong

doi:10.3389/fphys.2022.953880

Cited by 3 publications

(2 citation statements)

References 139 publications

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“…Other proteins in the same family, like RBPs, are involved in various processes in pancreatic β-cells, including insulin synthesis and secretion. Their expression in glucose-induced β-cells is mediated by the insulin receptor signaling pathway, which can decrease their expression [73].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Probiotic Supplements on Metabolic Parameters of People with Type 2 Diabetes in Greece—A Randomized, Double-Blind, Placebo-Controlled Study

Zikou,

Dovrolis,

Dimosthenopoulos

et al. 2023

Nutrients

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The role of probiotic supplementation in type 2 diabetes (T2D) treatment is controversial. The present study aimed to assess the effects of a multi-strain probiotic supplement (LactoLevureR (containing Lactobacillus acidophilus, Lactobacillus plantarum, Bifidobacterium lactis, and Saccharomyces boulardii)) over 6 months, primarily on glycemic control as well as on lipid levels and alterations in the gut microbiome, among individuals with T2D residing in Greece. A total of 91 adults with T2D (mean age [±SD] 65.12 ± 10.92 years, 62.6% males) were randomized to receive the probiotic supplement or a matching placebo capsule, once daily, for 6 months. Blood chemistries and anthropometric parameters were conducted every 3 months, and stool samples were collected at baseline and at 6 months. Significant reductions in HbA1c, fasting blood glucose, and total cholesterol were observed in participants treated with the probiotic supplement (n = 46) compared to the controls (n = 45), even after adjustment for a greater decrease in adiposity (waist circumference). Although there were no statistically significant differences in the diversity of the gut microbiome (α and β diversity), the administration of probiotics did influence several genera, metabolites, and key enzymes associated with diabetes. Overall, the administration of the multi-strain probiotic LactoLevureR over a 6-month period in individuals with T2D was well-tolerated and had a positive impact on metabolic parameters, alongside improvements in indices of adiposity.

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Section: Discussionmentioning

confidence: 99%

The Effect of Probiotic Supplements on Metabolic Parameters of People with Type 2 Diabetes in Greece—A Randomized, Double-Blind, Placebo-Controlled Study

Zikou,

Dovrolis,

Dimosthenopoulos

et al. 2023

Nutrients

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“…Splicing factors are essential in regulating RNA splicing by recognizing specific cis-regulatory sequences 20 . The expression levels of some spliceosome and RNA binding proteins (RBPs), which were significantly altered in insulin-resistant or T2D donors, were associated with the progress of the disease 21 , 22 . Splicing factors, NOVA1 , NOVA2 , ELAVL4 , PRFP8 / PRP8 , etc., which encode splicing factors or major spliceosomes, regulate insulin secretion or β-cell survivals 10 , 23 .…”

Section: Introductionmentioning

confidence: 99%

Regulation of endocrine cell alternative splicing revealed by single-cell RNA sequencing in type 2 diabetes pathogenesis

Wang,

Wen,

Chen

et al. 2024

Commun Biol

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The prevalent RNA alternative splicing (AS) contributes to molecular diversity, which has been demonstrated in cellular function regulation and disease pathogenesis. However, the contribution of AS in pancreatic islets during diabetes progression remains unclear. Here, we reanalyze the full-length single-cell RNA sequencing data from the deposited database to investigate AS regulation across human pancreatic endocrine cell types in non-diabetic (ND) and type 2 diabetic (T2D) individuals. Our analysis demonstrates the significant association between transcriptomic AS profiles and cell-type-specificity, which could be applied to distinguish the clustering of major endocrine cell types. Moreover, AS profiles are enabled to clearly define the mature subset of β-cells in healthy controls, which is completely lost in T2D. Further analysis reveals that RNA-binding proteins (RBPs), heterogeneous nuclear ribonucleoproteins (hnRNPs) and FXR1 family proteins are predicted to induce the functional impairment of β-cells through regulating AS profiles. Finally, trajectory analysis of endocrine cells suggests the β-cell identity shift through dedifferentiation and transdifferentiation of β-cells during the progression of T2D. Together, our study provides a mechanism for regulating β-cell functions and suggests the significant contribution of AS program during diabetes pathogenesis.

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Adaptive window space direction laser speckle contrast imaging to improve vascular visualization

Han

Wang³

et al. 2023

Biomed. Opt. Express

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Vascular visualization is crucial in monitoring, diagnosing, and treating vascular diseases. Laser speckle contrast imaging (LSCI) is widely used for imaging blood flow in shallow or exposed vessels. However, traditional contrast computation using a fixed-sized sliding window introduces noise. In this paper, we propose dividing the laser speckle contrast image into regions and using the variance criterion to extract pixels more suitable for the corresponding regions for calculation, and changing the shape and size of the analysis window at the vascular boundary regions. Our results show that this method has a higher noise reduction and better image quality in deeper vessel imaging, revealing more microvascular structure information.

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Post-transcriptional control by RNA-binding proteins in diabetes and its related complications

Cited by 3 publications

References 139 publications

The Effect of Probiotic Supplements on Metabolic Parameters of People with Type 2 Diabetes in Greece—A Randomized, Double-Blind, Placebo-Controlled Study

The Effect of Probiotic Supplements on Metabolic Parameters of People with Type 2 Diabetes in Greece—A Randomized, Double-Blind, Placebo-Controlled Study

Regulation of endocrine cell alternative splicing revealed by single-cell RNA sequencing in type 2 diabetes pathogenesis

Adaptive window space direction laser speckle contrast imaging to improve vascular visualization

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