Post-Therapy Profile of Serum Total Cholesterol, Retinol and Zinc in Pediatric Acute Lymphoblastic Leukemia and Non-Hodgkin's Lymphoma

Gokhale, Chanda D.; Udipi, Shobha; Ambaye, R. Y.; Pai, Sheila R; Advani, Suresh H.

doi:10.1080/07315724.2007.10719585

Cited by 10 publications

(8 citation statements)

References 28 publications

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“…Sgarbieri et al [51] revealed that the mean serum copper levels in ALL children at diagnosis was significantly higher than in healthy children; however, with the beginning of treatment, a notable decrease in serum copper concentration was observed. Similar results regarding the zinc level are reported by Gokhale et al [52], who indicated that mean serum zinc levels were comparable to controls suggesting that blood components that are administered as supportive care to the patients during therapy may have contributed to maintain serum zinc levels in optimal range.…”

Section: Discussionsupporting

confidence: 86%

Monitoring treatment response of childhood acute lymphocytic leukemia with certain molecular and biochemical markers

Barakat

Elkhayat

Kholoussi

et al. 2010

J Biochem & Molecular Tox

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Apoptosis is the primary mechanism through which most chemotherapeutic agents induce tumor cell death. The purpose of this study was to monitor the expression of pro- and anti-apoptotic proteins CD(95) , Bcl-2, as well as copper and zinc levels in the peripheral blood of children with acute lymphocytic leukemia (ALL) prior to and 6 months after the beginning of chemotherapy. Blood parameters and bone marrow blast count were also assessed. Twenty of 26 patients who received treatment showed amelioration in apoptotic response, which is reflected in the elevation of CD(95) , whereas Bcl-2 protein was significantly lowered. In these patients, the elevated serum copper level was not significantly affected whereas the low serum zinc level was significantly raised. Improvement in blood parameters and bone marrow blast count were also achieved. Taken together, the data suggested that assessment of apoptosis signaling molecules might have a predictive impact on treatment outcome.

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Section: Discussionsupporting

confidence: 86%

Monitoring treatment response of childhood acute lymphocytic leukemia with certain molecular and biochemical markers

Barakat

Elkhayat

Kholoussi

et al. 2010

J Biochem & Molecular Tox

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“…They are close to those recently found in pediatric acute lymphoblastic leukemia and non-Hodgkin's lymphoma. 20 The children of zinc-supplemented group had a significant weight gain of B2 kg during the study. Weight gain in children without leukemia has been reported.…”

Section: Discussionmentioning

confidence: 92%

Zinc supplementation in children and adolescents with acute leukemia

et al. 2013

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LZZ Consolo, P Melnikov, FZ Cô nsolo, VA Nascimento and JCDV Pontes BACKGROUND/OBJECTIVES: Zinc is known as an essential micronutrient for human health because of its structural and biochemical functions, influencing growth and affecting multiple aspects of the immune system. Zinc has been extensively studied in neoplastic processes but its role in children with leukemia still remains to be elucidated in several aspects. The aim of this study was to evaluate the effects of oral zinc supplementation on weight gain and infectious episodes in children and adolescents with acute leukemia. SUBJECTS/METHODS: This study included 38 patients, and was carried out as a randomized, double-blind, placebo-controlled investigation. The dosage of plasma zinc levels and the evaluation of nutritional status were performed during a period of 60 days. Zinc was supplemented orally, 2 mg/kg/day, in the form of amino acid salt. RESULTS:The results showed that plasma zinc concentrations did not increase significantly with the addition of the micronutrient. However, from a clinical point of view, it has become evident that supplementary zinc exerts a positive effect on nutritional status as positive weight gain. Moreover, the number of infection episodes was significantly reduced, possibly because of the immune stimuli. CONCLUSIONS: In conclusion, zinc supplementation can prevent some of the chemotherapy adverse effects in children with leukemia, improving their quality of life.

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“…Also, Akkus et al [198] demonstrated that serum copper levels were found to be higher in ALL cases than those of controls and that was attributed to high percentage of blood cells in bone marrow or in peripheral circulation. In addition, Sgarbieri et al [199] revealed that chemotherapy given to children has an important effect on their linear growth rate and nutritional status as well as their serum copper levels. The authors also showed that mean serum copper levels at diagnosis were significantly higher than in healthy children, and that there is a slightly decreased zinc concentration.…”

Section: Parameters Groupsmentioning

confidence: 99%

Expression of CD95 in Acute Lymphocytic Leukemia (ALL) in Egyptian Children before and after Treatment

Hanna¹

2015

J Blood Disord Transfus

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Acute lymphocytic leukemia (ALL) is a malignant disorder common among children. Apoptosis is a morphological process that leads to controlled cellular self-destruction and defective apoptotic pathways are greatly involved in tumor formation, progression, and metastasis. Apoptosis is the primary mechanism through which most chemotherapeutic agents induce tumor cell death. The purpose of this study was to monitor the expression of pro-and anti-apoptotic proteins CD 95 and Bcl-2 as well as copper and zinc levels in the peripheral blood of children with acute lymphocytic leukemia prior to, and six months after starting chemotherapy. The study was performed on twenty five children attending the outpatient clinic of the National Cancer Institute-Cairo University. Ten normal children were included in the study and considered as control group. Results showed that Total Leukocyte Count (TLC) and bone marrow blast count were significantly higher in ALL children than controls while after treatment TLC was normalized whereas bone marrow blast count was significantly decreased, hemoglobin and platelet count were significantly decreased when compared to controls while significantly increased after treatment. CD 95 % was significantly decreased before treatment relative to controls while it was significantly increased after treatment whereas Bcl-2 concentration showed significant increase before treatment compared to controls while it was significantly decreased after treatment. Serum Cu level showed significant increase in ALL cases at presentation compared to controls while it was not significantly changed after treatment. Serum Zn level was significantly decreased before treatment compared to controls while it was normalized after treatment. Cu/Zn was significantly higher in newly diagnosed ALL children than controls while it showed significant decrease after treatment. Negative significant correlation was found between CD 95 % and Bcl-2 on one hand and between serum Cu and Zn levels on the other hand. It could be concluded that CD 95 % and Bcl-2 might be useful diagnostic markers not only in the diagnosis but also in the follow up of ALL cases.

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Post-Therapy Profile of Serum Total Cholesterol, Retinol and Zinc in Pediatric Acute Lymphoblastic Leukemia and Non-Hodgkin's Lymphoma

Cited by 10 publications

References 28 publications

Monitoring treatment response of childhood acute lymphocytic leukemia with certain molecular and biochemical markers

Monitoring treatment response of childhood acute lymphocytic leukemia with certain molecular and biochemical markers

Zinc supplementation in children and adolescents with acute leukemia

Expression of CD95 in Acute Lymphocytic Leukemia (ALL) in Egyptian Children before and after Treatment

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