Post-therapeutic Surveillance Schedule for Oral Cancer: Is There Agreement?

Liu, Guicai; Dierks, Eric J.; Bell, R. Bryan; Bui, Tuan; Potter, Bryce E.

doi:10.1007/s10006-012-0356-3

Cited by 15 publications

(11 citation statements)

References 42 publications

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“…The literature, which comprises all HNCs rather than the oral cavity alone, remains equivocal on this subject. 26 Site-specific studies on laryngeal carcinomas and early-stage OSCC did not show survival benefits. 27 The proportion of patients treated with curative intent in our study did not differ between SPTs detected within 5 years (ie during the follow-up period) and those detected after 5 years, suggesting that it is safe to shorten the follow-up period.…”

Section: Discussionmentioning

confidence: 98%

“…Arguments for lifelong follow‐up are based on the assumption that early, asymptomatic, detection of new primary tumors leads to improved survival. The literature, which comprises all HNCs rather than the oral cavity alone, remains equivocal on this subject . Site‐specific studies on laryngeal carcinomas and early‐stage OSCC did not show survival benefits .…”

Section: Discussionmentioning

confidence: 99%

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Time patterns of recurrence and second primary tumors in a large cohort of patients treated for oral cavity cancer

et al. 2019

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Introduction Routine follow‐up after curative treatment of patients with oral squamous cell carcinoma (OSCC) is common practice considering the high risk of second primaries and recurrences (ie second events). Current guidelines advocate a follow‐up period of at least 5 years. The recommendations are not evidence‐based and benefits are unclear. This is even more so for follow‐up after a second event. To facilitate the development of an evidence‐ and personalized follow‐up program for OSCC, we investigated the course of time until the second and subsequent events and studied the risk factors related to these events. Materials and methods We retrospectively studied 594 OSCC patients treated with curative intent at the Head and Neck Cancer Unit of the Radboud University Medical Centre from 2000 to 2012. Risk of recurrence was calculated addressing death from intercurrent diseases as competing event. Results The 1‐, 5‐ and 10‐year cumulative risks of a second event were 17% (95% CI:14%;20%), 30% (95% CI:26%;33%), and 37% (95% CI:32%;41%). Almost all locoregional recurrences occurred in the first 2 years after treatment. The incidence of second primary tumors was relatively stable over the years. The time pattern of presentation of third events was similar. Discussion Our findings support a follow‐up time of 2 years after curative treatment for OSCC. Based on the risk of recurrence there is no indication for a different follow‐up protocol after first and second events. After 2 years, follow‐up should be tailored to the individual needs of patients for supportive care, and monitoring of late side‐effects of treatment.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Time patterns of recurrence and second primary tumors in a large cohort of patients treated for oral cavity cancer

et al. 2019

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“…There is no international consensus. 17 It has been suggested that for oral cancer an early discharge into primary care after two or three years might be an appropriate use of health resources. (Kanatas) 18 However, depending on risk of SP it could be argued that follow-up should be lifelong.…”

Section: Introductionmentioning

confidence: 99%

Incidence, timing, presentation, treatment, and outcomes of second primary head and neck squamous cell carcinoma after oral cancer

Rogers

Swain

Carroll

et al. 2019

British Journal of Oral and Maxillofacial Surgery

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Patients following their initial presentation of oral squamous cell carcinoma (SCC) have a lifelong risk of another new head and neck SCC. The present study aimed to establish the rates of second primary (SP), baseline characteristics (site, clinical or pathological stage, smoking and alcohol history), timing, presentation, treatment and outcomes. From the regional unit, records of patients treated with curative intent for their first oral cancer between 2002 and 2007 inclusive were analysed. Patients had at least 10 years of follow-up either to death or to the end of 2017. Of 347 patients treated with curative intent 29 had a SP at a median (IQR) of 52 (30-79) months after index surgery. All patients had at least 10 years of follow-up and the incidence of developing a second primary tumour within 2 years was 1.7% (95% CI: 0.7-3.7%), within 5 years was 4.9% (95% CI: 2.9-7.7% and within 10 years was 7.8% (95% CI: 5.1-11.1%). Early stage of first cancer was the only statistically significant factor (P=0.001) for SP within 10 years reflecting survivorship. SP were mainly (21 patients) staged as early and by visual inspection. Most (20) were located within the oral cavity with one of these overlapping the oropharynx, oropharynx (8) and larynx (1). The majority (22) were treated by surgery with curative intent and 3 were palliative. Patients need to be aware of the risk of SP and as most are in the mouth or oropharynx there is a role for surveillance by primary dental care. Manuscript with title (excluding any author details including names and affiliations) Click here to view linked References

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“…laryngeal cancer, or applicable to head and neck cancers in general and having a duration of at least five years. 26 The various follow-up schedules for oral cavity and head and neck cancer are listed in Table 1. 1, 2, 7, 8,[12][13][14][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] The majority of secondary events (69% -100%) of head and neck cancer, including oral cavity, is detected within the first three years after treatment.…”

Section: Introductionmentioning

confidence: 99%