Post-TB health and wellbeing

Nightingale, Rebecca; Carlin, Ffion; Meghji, Jamilah; McMullen, Kate; Evans, Denise; Zalm, Marieke M. van der; Anthony, M. G.; Bittencourt, Márcio Sommer; Byrne, Anthony; Preez, Karen Du; Coetzee, Marisa; Feris, C; Goussard, Pierre; Hirasen, Kamban; Bouwer, J; Hoddinott, Graeme; Huamán, Moisés A.; Inglis-Jassiem, Gakeemah; Ivanova, Olena; Karmadwala, Fatima; Schaaf, H. Simon; Ingrid, Schoeman; Seddon, James A.; Sineke, Tembeka; Solomons, Regan; Thiart, M; Toorn, Ronald van; Fujiwara, Paula I.; Romanowski, Kamila; Marais, Suzaan; Hesseling, Anneke C.; Johnston, James C.; Allwood, B W; Muhwa, Jeremiah Chakaya; Mortimer, Kevin

doi:10.5588/ijtld.22.0514

Cited by 38 publications

(42 citation statements)

References 229 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Long-term follow-up is essential in TB arthritis to assess treatment efficacy, monitor for disease recurrence, and manage potential sequelae such as joint deformities or functional impairments. Multidisciplinary care teams play a crucial role in providing comprehensive patient management throughout the treatment course [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Navigating Foot Tuberculosis in a Leprosy Survivor: A Case Managed Solely With Medical Strategies

Patel,

Pundkar,

Shrivastava

et al. 2024

Cureus

View full text Add to dashboard Cite

We present a case report of a 66-year-old male patient with a known history of leprosy who presented with pain and swelling in his right foot for the past 1.5 years. Fine needle aspiration cytology (FNAC) revealed non-inflammatory exudate, and Mycobacterium tuberculosis (MTB) was identified in the sample by the cartridge-based nucleic acid amplification test (CBNAAT). The patient was managed conservatively with anti-Koch's treatment (AKT), and a follow-up was conducted for 12 months to monitor the treatment response and overall progress. This highlights the importance of early diagnosis and appropriate medical management, along with a long-term follow-up, among patients with ankle tuberculosis, to reduce the need for surgical intervention.

show abstract

Section: Discussionmentioning

confidence: 99%

Navigating Foot Tuberculosis in a Leprosy Survivor: A Case Managed Solely With Medical Strategies

Patel,

Pundkar,

Shrivastava

et al. 2024

Cureus

View full text Add to dashboard Cite

show abstract

“…Key research questions of this study were informed by previous participatory research and advocacy from individuals with TB; in particular, calling for research in PTLD and other post-treatment outcomes, 28 and for inclusion of adolescent minors in research. 23 Individuals with TB were not involved in the study’s design.…”

Section: Methods and Analysismentioning

confidence: 99%

“…Post-treatment outcomes to be ascertained are informed by emerging research surrounding post-TB sequelae. 28 40 41 PTLD will be defined by new, recurrent or persistent respiratory symptoms or signs that occur post-treatment; hypoxaemia (oxygen saturation <90%); pulmonary function impairment or chest X-ray abnormalities. 40 Spirometry definitions for pulmonary function impairment include the following: forced expiratory volume in 1 S (FEV1)/forced vital capacity (FVC) ratio <lower limit of normal (LLN), FEV1<LLN and/or FVC<LLN.…”

Section: Methods and Analysismentioning

confidence: 99%

The Tuberculosis Sentinel Research Network (TB-SRN) of the International epidemiology Databases to Evaluate AIDS (IeDEA): protocol for a prospective cohort study in Africa, Southeast Asia and Latin America

Enane,

Duda,

Chanyachukul

et al. 2024

BMJ Open

View full text Add to dashboard Cite

IntroductionTuberculosis (TB) is a leading infectious cause of death globally. It is the most common opportunistic infection in people living with HIV, and the most common cause of their morbidity and mortality. Following TB treatment, surviving individuals may be at risk for post-TB lung disease. The TB Sentinel Research Network (TB-SRN) provides a platform for coordinated observational TB research within the International epidemiology Databases to Evaluate AIDS (IeDEA) consortium.Methods and analysisThis prospective, observational cohort study will assess treatment and post-treatment outcomes of pulmonary TB (microbiologically confirmed or clinically diagnosed) among 2600 people aged ≥15 years, with and without HIV coinfection, consecutively enrolled at 16 sites in 11 countries, across 6 of IeDEA’s global regions. Data regarding clinical and sociodemographic factors, mental health, health-related quality of life, pulmonary function, and laboratory and radiographic findings will be collected using standardised questionnaires and data collection tools, beginning from the initiation of TB treatment and through 12 months after the end of treatment. Data will be aggregated for proposed analyses.Ethics and disseminationEthics approval was obtained at all implementing study sites, including the Vanderbilt University Medical Center Human Research Protections Programme. Participants will provide informed consent; for minors, this includes both adolescent assent and the consent of their parent or primary caregiver. Protections for vulnerable groups are included, in alignment with local standards and considerations at sites. Procedures for requesting use and analysis of TB-SRN data are publicly available. Findings from TB-SRN analyses will be shared with national TB programmes to inform TB programming and policy, and disseminated at regional and global conferences and other venues.

show abstract

“…As such, understanding its effect on quality of life and health status is essential for patient care, evaluation of novel treatments or development of preventive strategies, and health policy [ 1 ]. Although it has been effectively treated for many years, and progress has been made in prevention and care, it still represents a global health problem for which the conditions and outcomes valued by the TB community need to be better understood [ 2 ]. Identifying patient-reported outcomes (PROs) reported by people affected by TB can provide a wealth of information about the impact of the disease.…”

Section: Introductionmentioning

confidence: 99%

People first: a participatory community approach on patient-reported outcomes in tuberculosis

Martín,

Barbosa,

Ramos

et al. 2024

Breathe

View full text Add to dashboard Cite

Patient-reported outcomes (PROs) play a crucial role in understanding the impact of tuberculosis (TB) on both individuals and communities. Despite advances in TB treatment, conventional outcome definitions often overlook essential components of people with TB's experiences, leading to disparities in treatment understanding. The incorporation of PROs in TB scientific research can help bridge the gap between the health system and people's needs and expectations. PROs can offer valuable insights into non-observable constructs like health literacy, self-efficacy and overall wellbeing, contributing to the comprehensive assessment of diagnosis, treatment and research end-points. Participatory community approaches, such as Community-Based Participatory, emphasise the engagement and involvement of relevant stakeholders in designing interventions tailored to their needs. Key stakeholders, including healthcare professionals, researchers, clinical trial investigators, public health officials, and community health workers, TB survivors and people with TB, can play a vital role in promoting patient-centred care and engaging directly with the TB-affected community. An increased and cross-collaborative effort for the inclusion of PROs in TB research can entail their potential role in developing effective treatment regimens and promoting adherence, while maximising community engagement and improving outcomes for those affected by TB.

show abstract

Post-TB health and wellbeing

Cited by 38 publications

References 229 publications

Navigating Foot Tuberculosis in a Leprosy Survivor: A Case Managed Solely With Medical Strategies

Navigating Foot Tuberculosis in a Leprosy Survivor: A Case Managed Solely With Medical Strategies

The Tuberculosis Sentinel Research Network (TB-SRN) of the International epidemiology Databases to Evaluate AIDS (IeDEA): protocol for a prospective cohort study in Africa, Southeast Asia and Latin America

People first: a participatory community approach on patient-reported outcomes in tuberculosis

Contact Info

Product

Resources

About