Post-surgical Outcomes of Different Surgical Techniques in Hirschsprung’s Disease: A Literature Review

Abstract

Hirschsprung's disease (HD) is a rare condition that affects newborns and is characterized by the lack of ganglion cells in the colon. Typical symptoms include difficulty passing stool, vomiting, and trouble feeding. Various surgical methods are available to manage the condition. The aim of the study is to investigate and compare the post-surgical outcomes of different surgical techniques used in the treatment of HD. A thorough literature search was conducted using various electronic databases to identify relevant studies to be referred to. Double-blinded screening of the identified articles led to the final selection of 40 out of 440 HD, including transanal endorectal pull-through (TERPT), laparoscopic approaches, and modified techniques. Several studies have investigated surgical procedures for HD, including TERPT, laparoscopic methods, and modified techniques. These have shown positive outcomes, with fewer complications, improved bowel function, and favorable cosmetic results. Individual patient characteristics and surgeon expertise should guide procedure selection. Surgery for HD aims to restore normal bowel function, but post-surgical outcomes can include constipation or fecal incontinence. Complications like enterocolitis, anastomotic stricture, and sphincter damage may occur. Laparoscopic approaches have shorter hospital stays. However long-term follow-up is essential to assess quality of life, psychological well-being, and potential side effects.

An Unexpected Case of Chronic Constipation in A 16-Year-Old Girl Turned Out to Be Hirschsprung’s Disease

“…The summary genetic view of HSCR susceptibility is that it arises primarily from the segregation of alterations in multiple genes, both rare and common, most of which impair signal transduction by the RET receptor tyrosine kinase [11]. [13]. Furthermore, primary or staged surgery for HD remains controversial.…”

“…Furthermore, primary or staged surgery for HD remains controversial. Presently, most doctors adopt the onestaged operation for HD patients due to the safety and efficacy of the procedure [14]. Older children may also undergo a preoperative period of rectal irrigations in order to attempt to decompress the bowel.…”

Analysis of early morphological and functional perivulnar changes in the mucosa of the cecum after suturing with different surgical threads

“…In abdominal surgery, particularly in pediatric surgery, the correct choice of suture material is the key to successful and rapid wound healing [13]. In pediatric surgery, the need for surgical interventions on the large intestine arises in several pathological conditions: acute appendicitis, congenital malformations (stenosis and atresia of the rectum, dolichosigma, megacolon), adhesive disease, intestinal invasion, in particular, ileocecal invasion [4,8,14]. In view of this, experimental studies to investigate the effect of sutures applied with different surgical threads on the morphological and functional state of large intestine tissues are considered relevant, timely and promising, and the development of new modified surgical suture materials is one of the urgent needs of modern abdominal surgery [1,3,6].…”