Post-surgical interval and lesion location within the limbic thalamus determine extent of retrosplenial cortex immediate-early gene hypoactivity

Poirier, Guillaume L.; Aggleton, John Patrick

doi:10.1016/j.neuroscience.2009.02.021

Cited by 36 publications

(46 citation statements)

References 68 publications

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“…The progression of these disruptions within the RSC is consistent with the idea that the granular RSC is more closely connected with limbic regions, while the dysgranular RSC is more closely connected with neocortical regions. For example, ATN lesions lead to dysregulation of IEG expression in the granular RSC in as little as 1 week, but did not affect the dysgranular RSC until around 1 year (Jenkins et al, 2004; Poirier and Aggleton, 2009). In contrast, lesions of the postrhinal cortex lead to IEG dysregulation in the dysgranular RSC without affecting the granular RSC (Jenkins et al, 2004).…”

Section: Functional Anatomymentioning

confidence: 99%

Cues, context, and long-term memory: the role of the retrosplenial cortex in spatial cognition

Miller¹,

Vedder²,

Law³

et al. 2014

Front. Hum. Neurosci.

151

129

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Spatial navigation requires memory representations of landmarks and other navigation cues. The retrosplenial cortex (RSC) is anatomically positioned between limbic areas important for memory formation, such as the hippocampus (HPC) and the anterior thalamus, and cortical regions along the dorsal stream known to contribute importantly to long-term spatial representation, such as the posterior parietal cortex. Damage to the RSC severely impairs allocentric representations of the environment, including the ability to derive navigational information from landmarks. The specific deficits seen in tests of human and rodent navigation suggest that the RSC supports allocentric representation by processing the stable features of the environment and the spatial relationships among them. In addition to spatial cognition, the RSC plays a key role in contextual and episodic memory. The RSC also contributes importantly to the acquisition and consolidation of long-term spatial and contextual memory through its interactions with the HPC. Within this framework, the RSC plays a dual role as part of the feedforward network providing sensory and mnemonic input to the HPC and as a target of the hippocampal-dependent systems consolidation of long-term memory.

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Section: Functional Anatomymentioning

confidence: 99%

Cues, context, and long-term memory: the role of the retrosplenial cortex in spatial cognition

Miller¹,

Vedder²,

Law³

et al. 2014

Front. Hum. Neurosci.

151

129

View full text Add to dashboard Cite

show abstract

“…Conversely, the multitude of overlapping pathways and connections across the extended hippocampal system may also permit a degree of functional redundancy across ATN neurocircuitry, and perhaps the extended system as a whole. Indeed, evidence that other structures are failing as a consequence of distal injury to the ATN, MTT and even the ventral tegmental nucleus of Gudden (Dumont et al, 2012;Dupire et al, 2013;Garden et al, 2009;Jenkins et al, 2004;Mendez-Lopez et al, 2013;Poirier and Aggleton, 2009;Reed et al, 2003;Vann and Albasser, 2009), raises an interesting question that is relevant to memory impairment associated with lesions to components of the extended hippocampal system and its related neurocircuitry. Can we reverse some of the seemingly permanent memory deficits produced by ATN lesions (and other system lesions)?…”

Section: The Anterior Thalamic Nuclei (Atn)mentioning

confidence: 99%

“…One of the most interesting consequences of ATN dysfunction in rats, discovered by John Aggleton, Seralynne Vann and their colleagues, is that ATN and mammillothalamic tract lesions (and lesions to the ventral tegmental nucleus of Gudden, the brain stem nucleus that projects to the MB) produce a dramatic, enduring and exacerbating reduction in the expression of immediate-early gene products (IEG), c-Fos and Zif268, in the retrosplenial cortex (Fig. 5) (Aggleton, 2008;Albasser et al, 2007;Amin et al, 2010;Dumont et al, 2012;Jenkins et al, 2002a,b;Jenkins et al, 2004;Poirier and Aggleton, 2009;Vann and Albasser, 2009;Vann et al, 2014).…”

Section: Recovery Using Cerebrolysin a Neurotrophic Drugmentioning

confidence: 99%

Anterior thalamic nuclei lesions and recovery of function: Relevance to cognitive thalamus

Dalrymple‐Alford

Harland

Loukavenko

et al. 2015

Neuroscience & Biobehavioral Reviews

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“…The diencephalon and recognition www.learnmem.org activity in diencephalic amnesia (Fazio et al 1992;Joyce et al 1994;Paller et al 1997;Reed et al 2003), (2) evidence that anterior thalamic strokes causing amnesia are sufficient to cause posterior cingulate hypoactivity (Clarke et al 1994), and (3) studies with rats showing how selective anterior thalamic lesions and mammillothalamic tract lesions can markedly reduce immediate-early gene expression in the posterior cingulate (retrosplenial) cortex and hippocampus yet leave both structures seemingly intact (Jenkins et al 2002(Jenkins et al , 2004Poirier and Aggleton 2009;Vann and Albasser 2009). These distal activity changes do not merely reflect the loss of afferent stimulation; there are also subtle intrinsic changes to the cortex itself (Poirier et al 2008).…”

Section: Toward a Model Of Diencephalic Contributions To Recognition mentioning

confidence: 99%

Unraveling the contributions of the diencephalon to recognition memory: A review

Aggleton¹,

Dumont²,

Warburton³

2011

Learn. Mem.

136

111

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Both clinical investigations and studies with animals reveal nuclei within the diencephalon that are vital for recognition memory (the judgment of prior occurrence). This review seeks to identify these nuclei and to consider why they might be important for recognition memory. Despite the lack of clinical cases with circumscribed pathology within the diencephalon and apparent species differences, convergent evidence from a variety of sources implicates a subgroup of medial diencephalic nuclei. It is supposed that the key functional interactions of this subgroup of diencephalic nuclei are with the medial temporal lobe, the prefrontal cortex, and with cingulate regions. In addition, some of the clinical evidence most readily supports dual-process models of recognition, which assume two independent cognitive processes (recollective-based and familiarity-based) that combine to direct recognition judgments. From this array of information a "multi-effect multinuclei" model is proposed, in which the mammillary bodies and the anterior thalamic nuclei are of preeminent importance for recollective-based recognition. The medial dorsal thalamic nucleus is thought to contribute to familiarity-based recognition, but this nucleus, along with various midline and intralaminar thalamic nuclei, is also assumed to have broader, indirect effects upon both recollective-based and familiarity-based recognition.Clinical studies repeatedly show that diencephalic pathology can impair recognition memory. Even so, there is no agreed locus within the diencephalon responsible for this memory loss and, hence, no agreed mechanism to explain the impairment. The present review examines both clinical and animal findings, and from this information a multi-effect multi-nuclei (MEMN) model emerges to explain the contributions of the diencephalon to recognition memory.At the outset, it is necessary to refine the focus of this review and to define some of its principal terms. The diencephalon comprises the thalamus and hypothalamus but, as will be explained, only the more medial parts of the diencephalon will be considered in detail. Recognition memory refers to the ability to detect whether a stimulus (e.g., a word, face, picture, object, or sound) has previously been encountered. As a consequence, this review is not about item identification (sometimes also confusingly referred to as recognition). Likewise, conditions that have broad disruptive effects on cognition, e.g., dementia, will not be considered even though recognition is typically impaired. Distinctions will be made between "item recognition," where the task is to determine if an individual item is novel or familiar, and "associative recognition," where all the individual items being experienced are familiar, but their particular combination is novel. A further, distinct ability is "recency" discrimination-the ability to determine which of two familiar stimuli has been experienced more recently. Both studies of amnesia and electrophysiological recordings show how recency memory and recogniti...

show abstract

Post-surgical interval and lesion location within the limbic thalamus determine extent of retrosplenial cortex immediate-early gene hypoactivity

Cited by 36 publications

References 68 publications

Cues, context, and long-term memory: the role of the retrosplenial cortex in spatial cognition

Cues, context, and long-term memory: the role of the retrosplenial cortex in spatial cognition

Anterior thalamic nuclei lesions and recovery of function: Relevance to cognitive thalamus

Unraveling the contributions of the diencephalon to recognition memory: A review

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