Post-stroke health-related quality of life at 3 and 12 months and predictors of change in a Danish and Arctic Norwegian Region

Heiberg, Guri Anita; Friborg, Oddgeir; Pedersen, Synne Garder; Thrane, Gyrd; Stabell, Henriette Holm; Nielsen, Jørgen Feldbæk; Anke, Audny

doi:10.2340/16501977-2716

Cited by 7 publications

(4 citation statements)

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“…When comparing our population with a population that included mainly patients with ischemic stroke (93%), our results indicate that hemorrhagic stroke, although less frequent than ischemic stroke, possibly causes greater limitations in hrQoL [ 20 ]. Therefore, similar attention should be paid to research on hemorrhagic stroke.…”

Section: Discussionmentioning

confidence: 99%

Spontaneous intracerebral hemorrhage – patients retrospectively consent to fibrinolytic surgery despite poor neurological outcome and reduced health-related quality of life

Schwiddessen,

Malinova,

von Steinbüchel

et al. 2024

Neurosurg Rev

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Spontaneous intracerebral hemorrhage (ICH) might lead to devastating consequences. Nonetheless, subjective interpretation of life circumstances might vary. Recent data from ischemic stroke patients show that there might be a paradox between clinically rated neurological outcome and self-reported satisfaction with quality of life. Our hypothesis was that minimally invasive surgically treated ICH patients would still give their consent to stereotactic fibrinolysis despite experiencing relatively poor neurological outcome. In order to better understand the patients’ perspective and to enhance insight beyond functional outcome, this is the first study assessing disease-specific health-related quality of life (hrQoL) in ICH after fibrinolytic therapy. We conducted a retrospective analysis of patients with spontaneous ICH treated minimally invasive by stereotactic fibrinolysis. Subsequently, using standardized telephone interviews, we evaluated functional outcome with the modified Rankin Scale (mRS), health-related Quality of Life with the Quality of life after Brain Injury Overall scale (QOLIBRI-OS), and assessed retrospectively if the patients would have given their consent to the treatment. To verify the primary hypothesis that fibrinolytic treated ICH patients would still retrospectively consent to fibrinolytic therapy despite a relatively poor neurological outcome, we conducted a chi-square test to compare good versus poor outcome (mRS) between consenters and non-consenters. To investigate the association between hrQoL (QOLIBRI-OS) and consent, we conducted a Mann-Whitney U-test. Moreover, we did a Spearman correlation to investigate the correlation between functional outcome (mRS) and hrQoL (QOLIBRI-OS). The analysis comprised 63 data sets (35 men, mean age: 66.9 ± 11.8 years, median Hemphill score: 3 [2-3]). Good neurological outcome (mRS 0–3) was achieved in 52% (33/63) of the patients. Patients would have given their consent to surgery retrospectively in 89.7% (52/58). These 52 consenting patients comprised all 33 patients (100%) who achieved good functional outcome and 19 of the 25 patients (76%) who achieved poor neurological outcome (mRS 4–6). The mean QOLIBRI-OS value was 49.55 ± 27.75. A significant association between hrQoL and retrospective consent was found (p = 0.004). This study supports fibrinolytic treatment of ICH even in cases when poor neurological outcome would have to be assumed since subjective perception of deficits could be in contrast with the objectively measured neurological outcome. HrQoL serves as a criterion for success of rtPa lysis therapy in ICH.

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Section: Discussionmentioning

confidence: 99%

Spontaneous intracerebral hemorrhage – patients retrospectively consent to fibrinolytic surgery despite poor neurological outcome and reduced health-related quality of life

Schwiddessen,

Malinova,

von Steinbüchel

et al. 2024

Neurosurg Rev

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“…The high prevalence of 'Poor' QoL ratings parallels findings from other research, where physical limitations are consistently reported as significant challenges for stroke survivors. These limitations are often coupled with psychological issues, such as depression and anxiety, which can exacerbate the perception of a lower QoL (14). Marital status, particularly the high proportion of married individuals in the study, is noteworthy.…”

Section: Discussionmentioning

confidence: 99%

Level of Quality of Life among Post Stroke Patients; A Cross Sectional Survey

Safdar,

Asghar,

Tahir

2023

JHRR

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Background: Stroke remains one of the leading causes of disability worldwide, with significant impacts on the quality of life (QoL) of survivors. This cross-sectional survey aims to evaluate the level of QoL among post-stroke patients and explore the associations with socio-demographic and clinical variables. Objective: The objectives of this study was to determine the level of quality of life among post-stroke patients. And to check the survival rate that either the stroke patients taking the therapeutic interventions or not, having a good independency or bad independency. Methodology: Cross-sectional study was conducted on 100 stroke patients having the age of less than 60. For the collection of data stroke specific quality of life scale (SS-QOL) was used to properly assess the quality of life among the selected population. Sample size was collected by using the convenient sampling technique. Written consent was taken from the respective hospitals Results: Results analyzed by SPSS version 25. The mean age of the patients was 50.28, ± 8.196 the minimum age was 32 years and maximum were 60 years. Out of 100 patients maximum were male 64% and female were 36%. There were 14% patients from upper-class level, 48% patients with a middle-class and 38% patients from a lower-class level. The overall quality of life among post stroke patient were poor with 52%, worst with 5%, fair with 39% and good with 4%. Conclusion: In this study it was observed that stroke has a negative impact on almost all the domains of quality of life. Majority of the patients were living with poor quality of life few of them were in good quality of life. On whole the quality of life is totally hampered and the patients were totally dependent.

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“…Quality of Life after Brain Injury -Overall Scale (QOLIBRI-OS; (50,51)) is a 6-item health-related quality of life measure (HRQoL) speci cally tailored to patients with brain injury. QOLIBRI-OS is preferable to the full 37-item QOLIBRI (52) in this feasibility study, since a global assessment of HRQoL is su cient, interference from fatigue and cognitive impairment are reduced (53,54) and participant response burden is low.…”

Section: Quality Of Lifementioning

confidence: 99%

“…QOLIBRI-OS scores range from 0-100, with 100 being the optimal score indicating best possible quality of life. A minimal clinically important change is a difference score of 12 (51). QOLIBRI-OS is validated for TBI and stroke (51), meets standard psychometric criteria for reliability (Cronbach's α = 0.86, test-retest reliability = 0.81) and has good construct validity in TBI populations (50).…”

Section: Quality Of Lifementioning

confidence: 99%

Self-directed versus peer-supported self-management for mental and sexual wellbeing after acquired brain injury: protocol for a feasibility randomised controlled trial

Wright

Walker-Clarke

Drummond

et al. 2023

Preprint

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Background Acquired brain injury (ABI) can lead to biopsychosocial changes such as depression, low self-esteem, and fatigue can cause, and be caused by, sexual issues affecting relationships and wellbeing. Given the relationship between sexual wellbeing and mental health, it is feasible that supporting sexual wellbeing will benefit psychological wellbeing. However, neurorehabilitation is inconsistent and often inadequate across the UK, and psychological, sexual, and social support is lacking. Research shows that self-management and peer-support programmes can improve quality of life, self-efficacy, and psychological wellbeing after brain injury. This protocol describes a feasibility randomised controlled trial (RCT) of a digital self-management programme to support mental and sexual wellbeing (known as HOPE4ABI), co-designed with and for people with ABI. Methods This mixed-methods feasibility RCT has two parallel trial arms of the 8-week digital HOPE4ABI self-management programme. Eligibility criteria includes: age > 18 years, sustained an ABI > 3 months prior to trial entry, access to internet enabled device, and ability to engage with the intervention. Referrals to the study website will be made via National Health Service (NHS), social media, and partnering organisations. Sixty eligible participants will be randomised at a ratio of 1:1 to peer-supported (n = 30) or self-directed (n = 30) HOPE4ABI programme. Primary feasibility outcomes include recruitment and retention rates, engagement, adherence, and usage. Secondary outcomes relate to standardised measures of quality of life, sexual wellbeing, and mental wellbeing. Participants and peer-facilitators will be interviewed after the course to assess acceptability across both trial arms. Discussion This feasibility trial data is not sufficiently powered for inferential statistical analyses but will provide evidence of feasibility of a full RCT. Quantitative trial data will be analysed descriptively, and participant screening data representing age, ethnicity and gender will be presented as proportions at group level. This data may indicate trends in reach to particular demographic groups that may inform future recruitment strategies to widen participation. Progression to a definitive trial will be justified, if predetermined criteria are met, relating to recruitment, retention: engagement, and acceptability. Trial Registration ISRCTN46988394 registered on 1st March 2023.

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Post-stroke health-related quality of life at 3 and 12 months and predictors of change in a Danish and Arctic Norwegian Region

Cited by 7 publications

References 0 publications

Spontaneous intracerebral hemorrhage – patients retrospectively consent to fibrinolytic surgery despite poor neurological outcome and reduced health-related quality of life

Spontaneous intracerebral hemorrhage – patients retrospectively consent to fibrinolytic surgery despite poor neurological outcome and reduced health-related quality of life

Level of Quality of Life among Post Stroke Patients; A Cross Sectional Survey

Self-directed versus peer-supported self-management for mental and sexual wellbeing after acquired brain injury: protocol for a feasibility randomised controlled trial

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