Post-streptococcal uveitis syndrome in a Caucasian population: a case series

Abstract

We report on the largest consecutive series of Caucasian patients under 16 years of age with PSUS. We have demonstrated a seasonal preponderance with presentation typically in winter or spring. We report a novel finding of corneal endotheliopathy in one of our PSUS patients. We also report on the benefit of adalimumab in the management of severe cases of PSUS; use of biologics in this particular cohort of uveitis patients has not previously been reported. With aggressive treatment our patients achieved good visual outcomes comparable to other published series.

Optical Coherence Tomography Findings in Nodular Anterior Scleritis due to Post-Streptococcal Syndrome

“…[1,[6][7][8] Reported cases of an ocular involvement of PSS include scleritis, in addition to uveitis, and rarely episcleritis, conjunctivitis, Brown's syndrome, optic disc edema, posterior scleritis, and glaucoma. [2,[7][8][9][10][11][12] However, previous studies reported PSS as an uncommon cause of uveitis or scleral inflammation. [2] To our knowledge, PSS was not figured among the possible causes of nodular anterior scleritis.…”

“…Poststreptococcal syndrome (PSS) includes all nonsuppurative complications of infections with group A streptococci. [1,2] It appears as an immunemediated reaction in any tissue of the body. [1] Acute rheumatic fever and acute glomerulonephritis are the common entities of PSS which most frequently involves young patients.…”

“…[1] Acute rheumatic fever and acute glomerulonephritis are the common entities of PSS which most frequently involves young patients. [1,2] Ocular involvement of PSS is uncommon and rare. [1,2] More precisely, PSS is not considered among the common causes of scleritis.…”

“…[1,2] Ocular involvement of PSS is uncommon and rare. [1,2] More precisely, PSS is not considered among the common causes of scleritis. [3,4] Scleritis is an inflammatory condition characterized by ocular pain and redness of the sclera.…”

Uveitis as an Open Window to Systemic Inflammatory Diseases

“…Bacterial: syphilis, tuberculosis, Lyme disease, cat-scratch disease, rickettsiosis, leptospirosis, brucellosis, Whipple's disease [30], chlamydiosis, tularemia, post-streptococcal [31] Parasitic: toxoplasmosis, toxocariasis, onchocerciasis, cysticercosisViral: herpes simplex viruses 1 and 2, CMV, HTLV-1, Dengue virus, Ebola virus, Zika virus, West-Nile virus, Rift valley fever virus, chikungunya virus, coronaviruses [32] Fungal: candidiasis, histoplasmosis, aspergillosis, cryptococcosis…”