Post salmonella irritable bowel syndrome — 5 year review

McKendrick, M W

doi:10.1016/s0163-4453(96)91715-6

Cited by 30 publications

(15 citation statements)

References 1 publication

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“…More recently, in a 6-year prospective analysis, Neal et al [52] reported only a slightly improved recovery rate in patients with PI-IBS compared to those with pre-existing IBS (43% vs 31%). Similarly, a poor prognosis was reported by McKendrick [53], in whose study 80% of patients with PI-IBS after Salmonella infection had persistent symptoms after 5 years. Long-term remission rates appear to be inversely related to psychiatric comorbidities [10], a finding that is seen in unspecified IBS as well.…”

Section: Prognosissupporting

confidence: 69%

“…Compared with IBS overall, PI-IBS has been associated with an increase in diarrheal symptoms and serotonin-releasing EC cells and a decrease in prevalence of psychiatric comorbidities. Despite an initial report suggesting a more favorable outcome compared with that of non-PI-IBS [51], the diagnosis of PI-IBS likely caries a similar long-term prognosis [52,53]. The pathophysiology of PI-IBS continues to evolve but appears to be associated with a low-grade inflammatory response that persists well after the resolution of acute enteric infection.…”

Section: Discussionmentioning

confidence: 99%

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Post-infectious irritable bowel syndrome

Dupont

2007

Curr Gastroenterol Rep

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Irritable bowel syndrome (IBS) is a common disorder associated with abdominal pain or discomfort and altered bowel habits. The majority of patients describe an insidious onset of symptoms; however, a subset report a fairly precise time of onset following an attack of acute gastroenteritis. Typically, the potential acute infectious symptoms, such as fever and vomiting, resolve after several days, but abdominal discomfort, bloating, and diarrhea persist. Although the underlying mechanism of post-infectious IBS (PI-IBS) has not been established, ongoing inflammation appears to play a role, with an increase in serotonin-containing enterochromaffin cells, T lymphocytes, mast cells, proinflammatory cytokines, and intestinal permeability. Psychiatric comorbidities are less common in PI-IBS, compared with IBS patients in general; however, the prevalence of psychological disorders is still higher compared with that in the general population and is associated with a poorer prognosis. Overall, patients with PI-IBS have a slightly improved prognosis compared with those with IBS without an infectious onset.

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Section: Prognosissupporting

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Post-infectious irritable bowel syndrome

Dupont

2007

Curr Gastroenterol Rep

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“…However, in a recent prospective study, symptoms were persistent in 75% of patients with PI-IBS, comparable with that observed within a general group of patients with IBS [4,13]. In a longer-term follow-up study, nine out of 11 patients still had IBS 5 years after Salmonella gastroenteritis [14]. This justifies a more proactive approach to management that is favored by this author.…”

Section: Introductionsupporting

confidence: 64%

Postinfectious irritable bowel syndrome

Gwee¹

2001

Curr Treat Options Gastro

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Postinfectious irritable bowel syndrome (PI-IBS) should be considered in patients who present with a change in bowel habits or an onset of new abdominal pain or discomfort following a recent confirmed or presumed exposure to infectious organisms, or in those who have recently returned from a tropical or developing country. In patients who are greatly distressed by their symptoms, an extended workup early in the course of their illness may give physician and patient confidence in focusing on IBS. The author favors a proactive, multicomponent approach to management, as it gives the physician and patient a sense of control. Treatment should include stress management, dietary advice to minimize exposure to trigger foods, and pharmacotherapy to alleviate anxiety and target disturbed physiology.

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“…6 A small but significant proportion of IBS of patients report onset of IBS symptoms following an episode of acute gastroenteritis (post-infectious IBS, PI-IBS). [7][8][9] PI-IBS has been reported following Shigella, 8 Salmonella, 9,10 and Campylobacter jejuni 7,11 infection. A unifying hypothesis to explain the pathogenesis of IBS remains elusive.…”

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confidence: 99%

Histopathological alterations in irritable bowel syndrome

Kirsch

Riddell

2006

Modern Pathology

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Irritable bowel syndrome is a common disorder defined by a symptom complex including abdominal pain and altered bowel habit. The etiopathogenesis appears to be multifactorial and to involve altered gastrointestinal motor function, enhanced perception of visceral stimuli and psychosocial factors. More recently a role for mucosal immune activation has been suggested. Routine histologic examination reveals no mucosal abnormality in the majority of cases but quantitative histological, immunohistochemical and ultrastructural analyses reveal subtle morphologic changes involving lymphocytes, mast cells, enterochromaffin cells and enteric nerves. The recent appreciation of these changes has led to new hypotheses linking central and enteric nervous systems to immune processes. This review highlights the spectrum of morphologic changes that occur in irritable bowel syndrome, examines their relationship to the pathophysiology of irritable bowel syndrome and considers their relevance to daily pathology practice.

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Post salmonella irritable bowel syndrome — 5 year review

Cited by 30 publications

References 1 publication

Post-infectious irritable bowel syndrome

Post-infectious irritable bowel syndrome

Postinfectious irritable bowel syndrome

Histopathological alterations in irritable bowel syndrome

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