Trend curves for WWER RPV materials (2.5Cr-Mo-V steel and its weld metal and 2Cr-Ni-Mo-V steel and its weld metal) and their supported structures (low-strength, low-alloy structural materials and welds) are presented. The main mechanisms of radiation and thermal embrittlement for RPV materials and support structures are considered, and service and metallurgical factors are taken into account.