Post-Prostate Biopsy Infection with Escherichia coli ST131 Leading to Epididymo-Orchitis and Meningitis Caused by Gram-Negative Bacilli

Assimacopoulos, A.; Johnston, Brian; Clabots, Connie; Johnson, James R.

doi:10.1128/jcm.02026-12

Cited by 22 publications

(23 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Assimacopoulus et al describe a case of necrotising epididymo-orchitis resulting from fluoroquinolone resistant E coli infection following TRUBP. 5 Ciprofloxacin resistant E coli has been observed in 22% of patients on rectal swab prior to biopsy. 6 Similar results, identifying preoperative fluoroquinolone resistant bacteria in 14% of patients, were reported by Duplessis et al, who recommended rectal swab cultures and targeted antibiotic therapy prior to TURBP.…”

Section: Discussionmentioning

confidence: 99%

Epidural abscess with associated spondylodiscitis following prostatic biopsy

Dobson

Cowie

Holliman

2015

annals

View full text Add to dashboard Cite

Spondylodiscitis is often iatrogenic in nature. We report the case of a 69-year-old man presenting with spondylodiscitis and associated epidural abscess following transrectal ultrasonography guided prostate biopsy despite ciprofloxacin cover. To our knowledge, this is the first case of spondylodiscitis secondary to fluoroquinolone resistant Escherichia coli. Prostate cancer is the most commonly diagnosed cancer in men, accounting for approximately a quarter of all male cancers. Transrectal ultrasonography guided biopsy of the prostate (TRUBP) is a common procedure in the diagnosis of prostate cancer and has a good safety profile. However, infective complications following biopsy (including bacteriuria, bacteraemia, fever and sepsis) are well documented, occurring in 2-4% of patients despite appropriate antibiotic cover.

show abstract

Section: Discussionmentioning

confidence: 99%

Epidural abscess with associated spondylodiscitis following prostatic biopsy

Dobson

Cowie

Holliman

2015

annals

View full text Add to dashboard Cite

show abstract

“…1,14,15 Many of these infections seem to be caused by E. coli ST 131, a clonal group within E. coli's phylogenetic group B2, which has emerged globally over the past decade. [16][17][18][19] This specific strain is characterized by its ability to combine an array of extraintestinal virulence factors with antimicrobial resistance, most notably FQ resistance.…”

Section: Discussionmentioning

confidence: 99%

Effective Control of an Outbreak of Sepsis After Prostate Biopsy Using Antibiogram-Guided Antimicrobial Prophylaxis

Baracco¹,

Kava²,

Caso

et al. 2014

Journal of Men's Health

View full text Add to dashboard Cite

Background: The emergence of strains of Escherichia coli (E. coli) that are resistant to fluoroquinolones (FQ) has resulted in an increase in infectious complications associated with transrectal ultrasound-guided prostate biopsy (TRUSPB). Two strategies have been proposed to deal with the increase: broadening the antimicrobial coverage and individualizing prophylaxis using transrectal swab cultures. This article describes an alternative strategy, one that adjusts TRUSPB prophylaxis, using the local antibiogram as a guide. Methods: In 2012, screening software for electronic medical records facilitated the identification of seven patients who presented with sepsis within 10 days of a TRUSPB at the Bruce W. Carter Department of Veterans Affairs Medical Center in Miami, Florida. At the time, TRUSPB antimicrobial prophylaxis consisted of oral ciprofloxacin and an intramuscular dose of gentamicin. The outbreak of TRUSPB-associated sepsis between January and June 2012 prompted a reassessment of this regimen, which, based upon the local antibiogram, was then changed to oral cefuroxime. Results: In 2011, one case of TRUSPB-associated sepsis was identified among 282 biopsies performed (0.4%). Between January and June 2012, seven cases occurred among 129 biopsies (5.4%). The facility's 2011 antibiogram revealed that 45% of E. coli strains were resistant to FQs and 10% were resistant to cephalosporins. A new regimen consisting of cefuroxime, an oral, second-generation cephalosporin, given twice daily, starting the evening before a TRUSPB, was implemented. One case of TRUSPB-associated sepsis occurred in the next 101 biopsies (1%). Conclusions: It is important for institutions to be aware of local microbiological trends and antimicrobial resistance. Local data from the institutional antibiogram can be a useful tool for making timely adjustments to antimicrobial prophylaxis for TRUSPB.

show abstract

“…Consisting of data provided by the authors to benefit the reader, the posted materials are not copyedited and are the sole responsibility of the authors, so questions or comments should be addressed to the corresponding author. Escherichia coli (postprocedure) [17] Mycobacterium tuberculosis a [18,19] Nocardia species [20] Viruses Enterovirus Dengue virus Lymphocytic choriomeningitis virus [21] Epstein-Barr virus Mumps virus [22] Herpes simplex virus West Nile virus [23] Human immunodeficiency virus…”

Section: Supplementary Datamentioning

confidence: 99%

Metagenomic Sequencing of an Echovirus 30 Genome From Cerebrospinal Fluid of a Patient With Aseptic Meningitis and Orchitis

Piantadosi

Mukerji

Chitneni

et al. 2017

Open Forum Infectious Diseases

View full text Add to dashboard Cite

Enteroviruses cause a wide spectrum of clinical disease. In this study, we describe the case of a young man with orchitis and aseptic meningitis who was diagnosed with enterovirus infection. Using unbiased “metagenomic” massively parallel sequencing, we assembled a near-complete viral genome, the first use of this method for full-genome viral sequencing from cerebrospinal fluid. We found that the genome belonged to the subgroup echovirus 30, which is a common cause of aseptic meningitis but has not been previously reported to cause orchitis.

show abstract

Post-Prostate Biopsy Infection with Escherichia coli ST131 Leading to Epididymo-Orchitis and Meningitis Caused by Gram-Negative Bacilli

Cited by 22 publications

References 14 publications

Epidural abscess with associated spondylodiscitis following prostatic biopsy

Epidural abscess with associated spondylodiscitis following prostatic biopsy

Effective Control of an Outbreak of Sepsis After Prostate Biopsy Using Antibiogram-Guided Antimicrobial Prophylaxis

Metagenomic Sequencing of an Echovirus 30 Genome From Cerebrospinal Fluid of a Patient With Aseptic Meningitis and Orchitis

Contact Info

Product

Resources

About