Post procedural pain with photodynamic therapy is more severe than skin surgery

Dixon, Andrew; Anderson, Stuart; Dixon, Mary P.; Dixon, John

doi:10.1016/j.bjps.2013.02.002

Cited by 6 publications

(5 citation statements)

References 24 publications

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“…In the larger studies comparing the outcome of severe pain, which requires a break in treatment or use of local infiltration anaesthesia, no significant differences were seen between cryotherapy, 5‐fluorouracil or imiquimod, whereas less pain was experienced with surgical excision than with PDT, although this would be expected as local anaesthesia is used for the surgical procedure . Of note, the pain and discomfort of other topical treatments, such as 5‐fluorouracil or imiquimod, is not directly comparable with PDT; the former are associated with increasing discomfort and inflammation during the course of treatment, over several weeks, whereas the pain experienced by PDT is maximal in the first few minutes of treatment and then subsides rapidly .…”

Section: Painmentioning

confidence: 97%

Adverse effects of topical photodynamic therapy: a consensus review and approach to management

et al. 2018

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Section: Painmentioning

confidence: 97%

Adverse effects of topical photodynamic therapy: a consensus review and approach to management

et al. 2018

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“…First, the practical usage of PTT/PDT is generally constrained by PAs/PSs because of the low tissue penetration of light, which leads to poor tumor cell death, tumor resistance to therapy, and possible excruciating pain during treatment [ 45 , 46 ]. Additionally, with the rise in local temperature around the tumor, adjacent normal tissues and cells may also suffer damage.…”

Section: Principles and Drawbacks Of Ptt/pdt In Antitumor Treatment A...mentioning

confidence: 99%

“…PDT is often classified as type I or type II, where type I produce O 2 − , hydroxyl radicals (•OH), and H 2 O 2 , and type II produce 1 O 2[42,43]. Although PTT and PDT may both cause tumor cell death by phototoxicity and producing ROS, they still have notable drawbacks in actual use[44].First, the practical usage of PTT/PDT is generally constrained by PAs/PSs because of the low tissue penetration of light, which leads to poor tumor cell death, tumor resistance to therapy, and possible excruciating pain during treatment[45,46]. Additionally, with the rise in local temperature around the tumor, adjacent normal tissues and cells may also suffer damage.…”

mentioning

confidence: 99%

Recent Progress of Copper-Based Nanomaterials in Tumor-Targeted Photothermal Therapy/Photodynamic Therapy

Zhuo,

Liu,

Aishajiang

et al. 2023

Pharmaceutics

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Nanotechnology, an emerging and promising therapeutic tool, may improve the effectiveness of phototherapy (PT) in antitumor therapy because of the development of nanomaterials (NMs) with light-absorbing properties. The tumor-targeted PTs, such as photothermal therapy (PTT) and photodynamic therapy (PDT), transform light energy into heat and produce reactive oxygen species (ROS) that accumulate at the tumor site. The increase in ROS levels induces oxidative stress (OS) during carcinogenesis and disease development. Because of the localized surface plasmon resonance (LSPR) feature of copper (Cu), a vital trace element in the human body, Cu-based NMs can exhibit good near-infrared (NIR) absorption and excellent photothermal properties. In the tumor microenvironment (TME), Cu2+ combines with H2O2 to produce O2 that is reduced to Cu1+ by glutathione (GSH), causing a Fenton-like reaction that reduces tumor hypoxia and simultaneously generates ROS to eliminate tumor cells in conjunction with PTT/PDT. Compared with other therapeutic modalities, PTT/PDT can precisely target tumor location to kill tumor cells. Moreover, multiple treatment modalities can be combined with PTT/PDT to treat a tumor using Cu-based NMs. Herein, we reviewed and briefly summarized the mechanisms of actions of tumor-targeted PTT/PDT and the role of Cu, generated from Cu-based NMs, in PTs. Furthermore, we described the Cu-based NMs used in PTT/PDT applications.

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Section: Introductionmentioning

confidence: 99%

“…As PDT has become more widely practiced in clinics for these indications, translational clinical researchers have sought to optimize patient compliance and satisfaction, with a focus on pain reduction. PDT-associated pain varies from patient to patient, but it can sometimes prove intolerable (11)(12)(13). In response to this, Wiegell et al (14) demonstrated that the combination of lowintensity light and the significant reduction in the PS incubation time can together greatly reduce the patient's perception of pain, without sacrificing efficacy for the treatment of AK.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Blue and White Lamp Light with Sunlight for Daylight‐Mediated, 5‐ALA Photodynamic Therapy, in vivo

Marra

LaRochelle

Chapman

et al. 2018

Photochem & Photobiology

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Daylight-mediated photodynamic therapy (d-PDT) as a treatment for actinic keratosis (AK) is an increasingly common technique due to a significant reduction in pain, leading to better patient tolerability. While past studies have looked at different light sources and delivery methods, this study strives to provide equivalent PpIX-weighted light doses with the hypothesis that artificial light sources could be equally as effective as natural sunlight if their PpIX-weighted fluences were equalized. Normal mouse skin was used as the model to compare blue LED light, metal halide white light and natural sunlight, with minimal incubation time between topical ALA application and the onset of light delivery. A total PpIX-weighted fluence of 20 J cm was delivered over 2 h, and the efficacy of response was quantified using three acute bioassays for PDT damage: PpIX photobleaching, Stat3 crosslinking and quantitative histopathology. These bioassays indicated blue light was slightly inferior to both sunlight and white light, but that the latter two were not significantly different. The results suggest that metal halide white light could be a reasonable alternative to daylight PDT, which should allow a more controlled treatment that is independent of weather and yet should have similar response rates with limited pain during treatment.

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Post procedural pain with photodynamic therapy is more severe than skin surgery

Cited by 6 publications

References 24 publications

Adverse effects of topical photodynamic therapy: a consensus review and approach to management

Adverse effects of topical photodynamic therapy: a consensus review and approach to management

Recent Progress of Copper-Based Nanomaterials in Tumor-Targeted Photothermal Therapy/Photodynamic Therapy

Comparison of Blue and White Lamp Light with Sunlight for Daylight‐Mediated, 5‐ALA Photodynamic Therapy, in vivo

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