Post-Pregnancy Osteoporosis a Syndrome ?

Nordin, B.E.C.; Röper, A

doi:10.1016/s0140-6736(55)90214-2

Cited by 141 publications

(77 citation statements)

References 5 publications

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“…Garofalidis", KAT General Hospital of Athens, 10 Athinas Str., 14561, Kifissia, Athens, Greece, Tel. : +306984229202, +302108018123, Fax: +302108018122, E-mail: kilampropoulou@gmail.com of PLO was made by Nordin et al in 1955. 1 It is characterised by the occurrence of fragility fracture(s), most commonly involving the lower thoracic and/ or lumbar vertebral bodies. The majority of cases are seen in the third trimester or early post-partum in primagravid women and the prominent clinical feature of PLO is severe and prolonged back pain and height loss.…”

Section: Abstract: Lactation Osteoporosis Pregnancy Premenopausalmentioning

confidence: 99%

Case Report: Teriparatide treatment in a case of severe pregnancy -and lactation- associated osteoporosis

Lampropoulou-Adamidou¹,

Trovas²,

Stathopoulos³

et al. 2012

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OBJEcTIVE: Pregnancy-and lactation-associated osteoporosis (PLO) is an uncommon disease. The majority of cases are seen in the third trimester or early post-partum in primagravid women and the prominent clinical feature of PLO is severe and prolonged back pain and height loss. The prevalence and aetiology of this disorder are as yet unclear and there are no guidelines for its treatment. cAsE rEPOrT: We report the outcomes of teriparatide (TrP) treatment in a woman suffering from severe PLO with 6 vertebral fragility fractures, severe back pain and very low BMD. rEsULTs: Thirteen months after the initiation of therapy, the patient was almost free of back pain. There was no new clinical vertebral fracture. Her laboratory tests were all normal. BMD increased by 24.4% at the lumbar spine, 9.9% and 4.6% at the left and the right total hip and 12.6% and 7.8% at the left and right femur neck, respectively. cONcLUsION: TrP treatment simultaneously with weaning and calcium and vitamin D supplementation seems to considerably increase BMD, improve severe back pain and quality of life and prevent further occurrence of vertebral fractures, making TrP a helpful tool in restoring bone strength in PLO patients. Key words: Lactation, Osteoporosis, Pregnancy, Premenopausal osteoporosis, TeriparatideCase report HORMONES 2012, 11(4):495-500 Address for correspondence: Kalliopi Lampropoulou-Adamidou, MD, MSc, Laboratory for the Research of the Musculoskeletal System "Th. Garofalidis", KAT General Hospital of Athens, 10 Athinas Str., 14561, Kifissia, Athens, Greece, Tel.: +306984229202, +302108018123, Fax: +302108018122, E-mail: kilampropoulou@gmail.com of PLO was made by Nordin et al in 1955. 1 It is characterised by the occurrence of fragility fracture(s), most commonly involving the lower thoracic and/ or lumbar vertebral bodies. The majority of cases are seen in the third trimester or early post-partum in primagravid women and the prominent clinical feature of PLO is severe and prolonged back pain and height loss. The prevalence and the ae tiology of this disorder are unclear. To date, more than 120 cases have been reported, mostly as individual case reports.2 Due to the lack of controlled trials and the rarity of the disease there are no formal guidelines.

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Section: Abstract: Lactation Osteoporosis Pregnancy Premenopausalmentioning

confidence: 99%

Case Report: Teriparatide treatment in a case of severe pregnancy -and lactation- associated osteoporosis

Lampropoulou-Adamidou¹,

Trovas²,

Stathopoulos³

et al. 2012

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“…Literatürdeki çoğu olguda tedavide ilk olarak emzirmenin sonlandırılması önerilmiştir (6,16). Laktasyon süresince süte geçen kalsiyum nedeniyle anne kanındaki düşen kalsiyum nedeniyle kemik rezorbsiyonu artar.…”

Section: Discussionunclassified

A Rare Cause of Low Back Pain in Pregnancy: Pregnancy Associated Osteoporosis

Yetişgin¹,

Dokumaci²,

Eren³

et al. 2016

Tod

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SummaryPregnancy associated osteoporosis is a rare entity seen at the third trimester of first pregnancy or early postpartum period. It does not recur frequently in the subsequent pregnancies; however, it might lead to various complications unless it is treated. In this paper, we presented a woman diagnosed with pregnancy-associated osteoporosis with back pain at the 6 th month of the pregnancy in order to discuss the points to be taken into consideration in the diagnosis/differential diagnosis and treatment options of pregnancy associated osteoporosis. Keywords: Pregnancy associated osteoporosis, pregnancy, lactation, low back pain Gebelikte Görülen Bel Ağrısının Nadir Bir Nedeni: Gebelikle İlişkili Osteoporoz A Rare Cause of Low Back Pain in Pregnancy: Pregnancy Associated OsteoporosisGebelikle ilişkili osteoporoz, genellikle ilk gebeliğin son trimesteri ile doğum sonrası ilk aylarda görülebilen nadir bir klinik durumdur. Sonraki gebeliklerde sıklıkla tekrarlamaz ve tedavi edilmezse birçok komplikasyona neden olabilir. Bu yazıda, gebeliğinin 6. ayında şiddetli bel ağrısı şikayeti başlayan ve gebelikle ilişkili osteoporoz tanısı konulan bir hasta sunularak, tanı/ayırıcı tanıda dikkat edilmesi gereken konular ile tedavi seçeneklerini tartıştık.

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“…Women pregnant or nursing for the first time or several times are known to have more osteoporosis. In 1955, Nordin reported the first four cases of osteoporosis in pregnant or nursing women 1) . Pregnancy -associated osteoporosis is classified as a primary osteoporosis in the Japanese Osteoporosis Society Guideline 2011.…”

Section: Discussionmentioning

confidence: 99%

“…It can be expected that such patients will develop severe osteoporosis at menopause. Although more than 60 years have passed since the first report of pregnancy -associated osteoporosis in the 1950s 1) , the prognosis of pregnancy -associated osteoporosis remains unclear. However, patients who develop osteoporosis in pregnancy and lactation would have a greater risk of fracture if they did not receive sufficient treatment to improve their BMD.…”

Section: Discussionmentioning

confidence: 99%

Four-Year Follow-Up of Pregnancy-Associated Osteoporosis: A Case Report

Takahashi

Arai

Kayama

et al. 2014

FJMS

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: A 22 -year -old woman presented with complaints of severe pain in a wide region of the thoracolumbar spine. She developed severe pain in the thoracolumbar spine region 2 months after her first delivery and was referred 1 month later. A lateral thoracic X -ray showed depressed degenerative vertebrae (T7, T9). One month after the initial examination, thoracic sagittal magnetic resonance imaging showed low intensity areas on T1 -weighted imaging and iso -high intensity areas on T2 -weighted imaging at T5, 7, 8, 9 and 11. Bone mineral density measured by ultrasound was low (%YAM 76%). The bone metabolic markers were high, suggesting accelerated osteoclast activity. These findings prompted a diagnosis of pregnancy -associated osteoporosis. She was asked to stop breastfeeding and to wear a lumbar brace, and treatment with nutritional calcium, activated vitamin D3, and risedronate sodium was started. Her low back pain almost disappeared after treatment. Bone metabolic markers showed normalization 8 months after the initial examination. Risedronate sodium was stopped 2 years and 2 months after the initial examination. Teriparatide treatment was started because her bone mineral density remained low ; however, the osteoblast marker P1NP was not increased 5 months after the start of teriparatide treatment.

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Post-Pregnancy Osteoporosis a Syndrome ?

Cited by 141 publications

References 5 publications

Case Report: Teriparatide treatment in a case of severe pregnancy -and lactation- associated osteoporosis

Case Report: Teriparatide treatment in a case of severe pregnancy -and lactation- associated osteoporosis

A Rare Cause of Low Back Pain in Pregnancy: Pregnancy Associated Osteoporosis

Four-Year Follow-Up of Pregnancy-Associated Osteoporosis: A Case Report

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