Post pandemic research priorities: A consensus statement from the HL-PIVOT

Faghy, Mark A; Arena, Ross; Babu, Abraham Samuel; Christle, Jeffrey W.; Marzolini, Susan; Popović, Dejana; Vermeesch, Amber; Pronk, Nicolaas P.; Stoner, Lee; Smith, Andy

doi:10.1016/j.pcad.2022.07.001

Cited by 9 publications

(4 citation statements)

References 52 publications

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“…2 No confirmation tests n = 23. 3 Median ranges 1%-95%. 4 Times since the last vaccine dose/infection.…”

Section: Resultsmentioning

confidence: 99%

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Cellular Immunity of SARS-CoV-2 in the Borriana COVID-19 Cohort: A Nested Case–Control Study

Domènech-Montoliu,

Puig-Barberà,

Pac-Sa

et al. 2024

Epidemiologia

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Our goal was to determine the cellular immune response (CIR) in a sample of the Borriana COVID-19 cohort (Spain) to identify associated factors and their relationship with infection, reinfection and sequelae. We conducted a nested case–control study using a randomly selected sample of 225 individuals aged 18 and older, including 36 individuals naïve to the SARS-CoV-2 infection and 189 infected patients. We employed flow-cytometry–based immunoassays for intracellular cytokine staining, using Wuhan and BA.2 antigens, and chemiluminescence microparticle immunoassay to detect SARS-CoV-2 antibodies. Logistic regression models were applied. A total of 215 (95.6%) participants exhibited T-cell response (TCR) to at least one antigen. Positive responses of CD4+ and CD8+ T cells were 89.8% and 85.3%, respectively. No difference in CIR was found between naïve and infected patients. Patients who experienced sequelae exhibited a higher CIR than those without. A positive correlation was observed between TCR and anti-spike IgG levels. Factors positively associated with the TCR included blood group A, number of SARS-CoV-2 vaccine doses received, and anti-N IgM; factors inversely related were the time elapsed since the last vaccine dose or infection, and blood group B. These findings contribute valuable insights into the nuanced immune landscape shaped by SARS-CoV-2 infection and vaccination.

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“…2 No confirmation tests n = 23. 3 Median ranges 1%-95%. 4 Times since the last vaccine dose/infection.…”

Section: Resultsmentioning

confidence: 99%

“…Research on the SARS-CoV-2 evolution, the pandemic’s progression and its impact on human health remains critical; this includes studying the immune response to the infection and vaccinations. Such research is essential for guiding health strategies and medical interventions [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Cellular Immunity of SARS-CoV-2 in the Borriana COVID-19 Cohort: A Nested Case–Control Study

Domènech-Montoliu,

Puig-Barberà,

Pac-Sa

et al. 2024

Epidemiologia

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“…This shift has both short‐ and long‐term consequences, as it impacts the progress made in various areas of healthcare research. Additionally, the pandemic has highlighted the importance of interdisciplinary research and collaboration, as researchers from diverse fields have come together to address the urgent challenges posed by COVID‐19 [ 118 , 119 , 120 , 121 , 122 ].…”

Section: Navigating the Pandemic: Impacts And Interventionsmentioning

confidence: 99%

COVID‐19 retreats and world recovers: A silver lining in the dark cloud

Bisen

Agrawal

Sanap

et al. 2023

Health Care Science

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The coronavirus disease (COVID‐19), which the World Health Organization classified as the Sixth Public Health Emergency Of International Concern (PHEIC) on January 30, 2020, is no longer a PHEIC. Millions were affected due to unawareness. The increase in fatalities and shortage of medicine was the first outrage of COVID‐19. As per the Johns Hopkins COVID‐19 resource center database, it was observed that the disease has spread dynamically across 200+ nations worldwide affecting more than 600 million people from 2019 to 2023, and over thousands of people were victimized regularly at a 2% mortality rate (approx.). In the midway, the mutant variants of concern like omicron, and delta have also created havoc and caused significant impact on public health, global economy, and lifestyle. Since 2019, 3 years now passed and the dynamic disease statistics seem decelerated; moreover, the prevalence of COVID‐19 is also fading. The Johns Hopkins resource center has also stopped recording the data of the global pandemic recently from March 10, 2023. Hence, based on the facts, we are presenting a concise report on the pandemic from 2019 to 2023, which includes a brief discussion of the global pandemic. We have highlighted global epidemiology, emphasizing the Indian COVID scenario, vaccination across the globe, and the psychosocial and geopolitical consequences of COVID‐19 with a brief background to pathology, clinical management, and the worldwide response against triage. A lot has changed and still needs to change after three tough years of COVID‐19. Even though science has progressed and advanced research in medicine is pointing toward future generations, there is no standard care supplied for COVID‐19‐like calamities. COVID‐19 cases might have declined but its influence on the society is still stagnant. This COVID experience has taught us that, despite our bleak beginnings, there is always hope for the future and that we must act with foresight to improve things for future generations.

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“…All in all, COVID-19 is not the first pandemic, and it will not be the last ( 14 ). Beyond defeating this pandemic, the big test that all countries will soon face is whether the lessons from this experience have shaped new shared goals after the crisis ( 6 ).…”

Section: Introductionmentioning

confidence: 99%

The necessity revealed by COVID-19 pandemic: Paradigm shift of Iran's healthcare system

Mohammadpour

Delavari

Kavosi

et al. 2023

Front. Public Health

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BackgroundCOVID-19 pandemic has resulted in drastic changes around the world, revealing vulnerable aspects of healthcare systems. This study aimed to explore how Iranian healthcare system experienced the paradigm shift during the pandemic and determine the aspects that need improvement during the pandemic era.MethodThis qualitative study was conducted in 2021. A framework analysis approach was used to analyze the content of the 19 semi-structured interviews with the healthcare system experts from Shiraz University of Medical Sciences (SUMS). The interviews‘ audio files changed into transcript after each session and data was saturated at the 19 interview. To increase the trustworthiness of the study, Guba and Lincoln's criteria including credibility, transferability, dependability, and confirmability were used. Goldsmith's five-step framework analysis was used applying MAX QDA version 10 software.ResultEight main themes and 20 subthemes were explored. The main themes included “strengthening the electronic health infrastructure,” “research for evidence-based decision making,” “dedicated financing to the pandemic,” “prevention of disruption in the effective provision of services and medicines,” “enriching the authority of the Ministry of Health by focusing on interactions,” “recruiting, managing and empowering health human resources with attention to financial and non-financial incentives,” “reforming educational approaches in training students in medical universities,” as well as “lessons learned from neglected aspects.”ConclusionTo be ready to respond to a possible future pandemic and for a paradigm shift, bold steps must be taken to make fundamental changes in various aspects of the healthcare system including e-health development, evidence-based decision making, dedicated budgets for pandemics, reinforcement of interactions at the national and international level, as well as sufficient attention to healthcare workers from all financial, non-financial and educational aspects.

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Post pandemic research priorities: A consensus statement from the HL-PIVOT

Cited by 9 publications

References 52 publications

Cellular Immunity of SARS-CoV-2 in the Borriana COVID-19 Cohort: A Nested Case–Control Study

Cellular Immunity of SARS-CoV-2 in the Borriana COVID-19 Cohort: A Nested Case–Control Study

COVID‐19 retreats and world recovers: A silver lining in the dark cloud

The necessity revealed by COVID-19 pandemic: Paradigm shift of Iran's healthcare system

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