Post-operative Radiotherapy for the Treatment of Malignant Solitary Fibrous Tumor of the Nasal and Paranasal Area

Xue, Ying; Chai, Guangjin; Xiao, Feng; Wang, Ning; Mu, Yun-Feng; Wang, Yujie; Shi, Mei

doi:10.1093/jjco/hyu100

Cited by 20 publications

(21 citation statements)

References 27 publications

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“…Therefore, there is an overall good behavior with low local recurrence rate, different from other anatomic sites [39]. Although not reported in the sinonasal tract, SFTs in patients [55 years, with large tumors ([15 cm), with necrosis, increased mitotic activity and/or pleomorphism or incomplete resection are designated as ''malignant'' or ''dedifferentiated'' SFT [40,41], associated with metastasis and disease-specific mortality [42]. Treatment of sinonasal tract SFTs is usually by complete excision or by wide excision.…”

Section: Clinical Featuresmentioning

confidence: 99%

Update on Select Benign Mesenchymal and Meningothelial Sinonasal Tract Lesions

Thompson

Fanburg‐Smith

2016

Head and Neck Pathol

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Section: Clinical Featuresmentioning

confidence: 99%

Update on Select Benign Mesenchymal and Meningothelial Sinonasal Tract Lesions

Thompson

Fanburg‐Smith

2016

Head and Neck Pathol

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“…While the rarity of SFT/HPCs has limited the study of adjuvant therapies, a number of small case series have observed prolonged tumor-free survival when radiation is combined with surgical resection [25,26,27], suggesting that adjuvant therapy may be of benefit after gross total resection in certain patients. The role of chemotherapy is even less defined, particularly as it has typically been reserved for salvage therapy in progressive SFT no longer amenable to resection.…”

Section: Discussionmentioning

confidence: 99%

Rare Occurrence of an Intraocular Choroidal Solitary Fibrous Tumor/Hemangiopericytoma

Rinaldo

Eggers

et al. 2017

Ocul Oncol Pathol

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Purpose: Tumors previously diagnosed as solitary fibrous tumors (SFT) and hemangiopericytomas (HPC) are characterized by the NAB2-STAT6 fusion gene, leading to nuclear STAT6 expression, and are now considered part of one SFT/HPC tumor entity by the 2016 World Health Organization Classification of Tumors of the Central Nervous System. We present the first primary choroidal SFT/HPC with the diagnosis confirmed by STAT6 expression. Procedures: A 51-year-old man underwent enucleation for a choroidal mass, which revealed a spindle cell neoplasm involving the optic nerve, without extrascleral extension. Immunohistochemical stains for S-100, melan-A, tyrosinase, and HMB45 were all negative; however, detection of monosomy 3 by FISH favored a choroidal spindle cell melanoma. Four years later, he presented with hepatic metastases of a spindle cell tumor, and a year later with an epithelioid malignancy involving the calvarium. Results: The calvarial tumor showed nuclear STAT6 immunoreactivity, supporting the diagnosis of SFT/HPC. Retrospectively, the choroidal and hepatic masses were also found to demonstrate nuclear STAT6 expression, supporting the diagnosis of a primary choroidal SFT/HPC with metachronous metastases to the liver and calvarium. Conclusions: This case highlights the significance of considering SFT/HPC in the diagnosis of intraocular spindle cell tumors and the importance of STAT6 immunohistochemistry in the evaluation of such tumors.

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“…Solitary fibrous tumors (SFTs) most often originate in the pleura, with other common sites of occurrence including the extremities, mediastinum, peritoneum, and orbit [4]. The key diagnostic criterion of these tumors is their immunohistochemical reactivity, with CD34 and STAT6 being the most commonly observed cell markers [2,5-6].…”

Section: Discussionmentioning

confidence: 99%

“…A recent study by Doyle, et al reports that 98% of tumors expressing STAT6 are confirmed to be SFTs [7]. These tumors are rarely malignant, but 10%-15% may metastasize to the lungs, bones, and liver [4]. …”

Section: Discussionmentioning

confidence: 99%

“…Solitary fibrous tumors are exceedingly rare in the pediatric population and create a diagnostic dilemma. Once identified, the treatment of choice for SFTs is radical surgical resection [4]. Given the rarity of SFTs overall, the presenting age of the patient and atypical location of the tumor warrant further discussion in terms of diagnostic measures and case management of pediatric patients presenting with neck masses.…”

Section: Introductionmentioning

confidence: 99%

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Rare Solitary Fibrous Tumor in the Pediatric Neck: A Case Report and Review of the Literature

White

Cox

Schwartz

et al. 2017

Cureus

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Solitary fibrous tumors (SFT) are a rare type of mesenchymal-derived tumor not commonly found in the pediatric population, especially in the head and neck. Tumors of this nature are most commonly seen in the adult population and are identified with unique immunohistochemical markers, specifically signal transducer and activator of transcription 6 (STAT6) and hematopoietic progenitor cell antigen (CD34). Including SFTs in the differential diagnosis while working up a mass can be difficult considering their relatively non-descript appearance on imaging and the low yield immunohistochemical staining that must be ordered to confirm diagnosis. The current literature identifies only a handful of cases of SFTs occurring in the pediatric population, with a majority arising from the pleura. We present the case of a 13-year-old male who underwent radical excision of a left occipital triangle neck mass after radiological and pathological workup failed to conclusively make a diagnosis. Postoperative pathologic analysis revealed it to be an SFT. Due to the exceptionally rare presentation of SFTs in pediatric patients, the aim of this case report is to discuss diagnostic measures, solitary fibrous tumor etiology, as well as a recent risk stratification system used for the evaluation of postoperative disease progression. Our hope is that clinicians will include SFTs in their differential diagnosis when working up a neck mass in the pediatric population.

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Post-operative Radiotherapy for the Treatment of Malignant Solitary Fibrous Tumor of the Nasal and Paranasal Area

Cited by 20 publications

References 27 publications

Update on Select Benign Mesenchymal and Meningothelial Sinonasal Tract Lesions

Update on Select Benign Mesenchymal and Meningothelial Sinonasal Tract Lesions

Rare Occurrence of an Intraocular Choroidal Solitary Fibrous Tumor/Hemangiopericytoma

Rare Solitary Fibrous Tumor in the Pediatric Neck: A Case Report and Review of the Literature

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