Post‐operative pain management with meloxicam: a systematic literature review in the field of dentistry

Abstract

Aim: Pain is one of the clinical problems after orofacial surgeries. There have been various studies about the analgesic effect of nonsteroidal antiinflammatory drugs (NSAIDs) in this group of surgeries. In recent years, meloxicam has undergone clinical trials in dentistry. The purpose of this study was to review the efficacy of meloxicam on postoperative pain in dentistry. Materials and methods: The study design was in accordance with the PRISMA guidance. The keywords according to MeSH and related articles were searched in the EBSCO, MEDLINE (via Ovid), PubMed, Science Direct, Scopus, Web of Science and Google Scholar databases. Then eligible randomized clinical trials articles, which released up to December 2017, were thoroughly reviewed. Results: The nine eligible articles were studied. Meloxicam was administered with doses of 7.5, 10 and 15 mg (oral or intramuscular) before or after the third molar extraction. Meloxicam has a similar or significantly better analgesic effect than some of the selective and nonselective NSAIDs and significantly has a better analgesic effect than some of salicylic acids and tramadol. Conclusion: Meloxicam can be considered as an alternative analgesic agent than some NSAIDs, tramadol and salicylic acids in patients who have undergone the third molar extraction.The best way to pain intensity control following orofacial surgeries has not yet been introduced. According to a common rule, non-steroidal anti-inflammatory drugs (NSAIDs), acetaminophen or their combination are the most prescribed items for of pain intensity control after orofacial surgery 6,7 .Up to now, many studies have been conducted to evaluate the effectiveness of different analgesic drugs, including opioids, corticosteroids, salicylic acids and NSAIDs in dentistry. Generally, selective cyclooxygenase-2 (COX-2) inhibitor NSAIDs may be preferred over their non-selective ones in terms of pain intensity control and a decrease in additional Oral Surgery 13 (2020) 188--196.

Preemptive use of anti-inflammatories and analgesics in oral surgery: a review of systematic reviews

“…Oral and IM routes: Meloxicam (7.5, 10, and 15 mg, oral route) and meloxicam (7.5 and 15 mg, IM) were evaluated for postoperative pain management in patients undergoing third molar surgery. Meloxicam (any dose) had similar analgesic effects to naproxen (550 mg), diflunisal (500 mg), acetaminophen (500 mg), rofecoxib (12.5 mg), and nimesulide (100 mg) and a superior analgesic effect compared to ampiroxicam (27 mg), diclofenac (100 mg), salicylates, and tramadol ( Khosraviani et al, 2020 ).…”

Effectiveness of photodynamic therapy with curcumin against Candida species: A systematic review

“…Search results were limited to original English-language articles published by the end of 2020 using options available on the website of each database. Also, to extend the search scope, the keywords were searched in Google Scholar and the first 200 titles displayed were examined, and qualified studies were included in the study [25] . The titles were then merged into Mendeley desktop software (ver.…”