Post-operative antibiotic use in nonperforated appendicitis

Le, Dinhkim; Rusin, Wendy; Hill, B. Jay; Langell, John T.

doi:10.1016/j.amjsurg.2009.05.028

Cited by 34 publications

(31 citation statements)

References 7 publications

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“…In the case of suppurative appendicitis, studies have concluded that there is no benefit of antibiotics for the prevention of postoperative complications [29][30][31] . For the complicated appendicitis, on the other hand, some researches have reported that there might to be a certain benefit to postoperative antibiotics; however, no optimal duration of antibiotics treatment was clearly identified [29,32] .…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for Postoperative Intra-Abdominal Abscess after Laparoscopic Appendectomy: Analysis for Consecutive 1,817 Experiences

et al. 2015

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Background: Possible risk factors for postoperative intra-abdominal abscess (IAA) formation after laparoscopic appendectomy (LA) remain controversial. A perforated appendicitis, diabetes mellitus, peritoneal irrigation, obesity and age are considered to be possible risk factors for postoperative IAA, but the existing evidence is insufficient. This study aimed to identify the risk factors for IAA formation in patients receiving LA. Methods: Between January 2010 and December 2013, 1,817 patients who underwent 3-port LA were enrolled in this study. Patients were classified into 2 groups according to the development of postoperative IAA, and the differences between the groups were analyzed. Results: The incidence of IAA after LA was 1.5%, and the only identified risk factor for IAA was peritoneal irrigation. On logistic regression analysis of those patients who received peritoneal irrigation, suppurative appendicitis and non-placement of the peritoneal drain were found to be significant risk factors for the development of IAA. Conclusions: Peritoneal irrigation in a case of abdomen contamination was shown to be a risk factor for the development of postoperative IAA after LA. When peritoneal irrigation is performed, surgeons should consider using peritoneal drainage and postoperative antibiotics (including anti-anaerobic antibiotics) to prevent postoperative IAA formation.

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Section: Discussionmentioning

confidence: 99%

Risk Factors for Postoperative Intra-Abdominal Abscess after Laparoscopic Appendectomy: Analysis for Consecutive 1,817 Experiences

et al. 2015

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“…18 They observed no significant difference in surgical site infection rate between the groups (10% vs. 9%, p = 0.64). In our study we used single preoperative antibiotic dose and two postoperatively.…”

Section: Discussionmentioning

confidence: 87%

“…[7][8][9][10][11][12] Disease process at the time of operation and the use of appropriate prophylactic antibiotics significantly affects the risk for postoperative surgical site infections in addition to patient's factors. 8,12 . The efficacy of antibiotics in reducing the risk of surgical site infections following appendicectomy has been well established in the literature.…”

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confidence: 99%

Metronidazole in Acute Non-perforated Appendicitis

2017

J Surg Pak

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“…Postoperative wound Infection can increase the morbidity and increase postoperative pain and sepsis lead to higher rates of hospital readmission with increased length of hospital stay [10,11,12]. Patients with perforated appendicitis after appendectomy are usually treated with a variable course of postoperative antibiotics because of heavy contamination of wound and peritoneal cavity however, the role of postoperative antibiotics in reducing the infective complications in non perforated appendicitis is still controversial [7,13,14].…”

Section: Discussionmentioning

confidence: 99%

“…Similarly Le et al [14] retrospectively reviewed 507 patients with nonperforated appendicitis who had received adequate preoperative antibiotics, 63% of whom had received postoperative antibiotics. Their study concluded that; the addition of postoperative antibiotics did not affect the rate of postoperative SSIs in their analysis (10% vs 9%, P = 0.64).…”

Section: Discussionmentioning

confidence: 99%

Postoperative Use of Antibiotics in Adults with Non-perforated Appendicitis Subjected to Open Appendectomy

Mlees¹

2017

ASS

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Acute appendicitis is the most common cause of acute abdominal pain necessitating appendicectomy. The aim of this study was to determine the role of postoperative antibiotics in non-perforated appendicitis regarding; superficial site infections (SSIs), deep site infections (DSIs), complications and the length of hospital stay. This prospective study was carried out on 112 patients diagnosed as acute appendicitis at the Emergency Hospital, General Surgery Department, Tanta University Hospital from March 2014 to April 2016. The patients classified into two groups: Group 1: patients who received postoperative antibiotics, these included 55 patients and Group 2: patients who did not receive postoperative antibiotics and these included 57 patients. The patients subjected to open appendectomy through a standard Grid-Iron incision. The patients' characteristics, ultrasound findings, antibiotics regimen, operative diagnosis, length of hospital stay, wound infection, complications and histopathological findings were analysed using SPSS V 20. Out of 112 patients, 72 patients were male and 40 patients were female. The patients' age ranged from 18 to 55 years with a mean age of 26 years. There is no significant difference regarding patient's age, sex, medical comorbidities, fever, radiologic findings or operative time between the two groups. Treatment with postoperative antibiotics did not significantly reduce the risk of developing superficial SSIs, DSIs. The patients received postoperative antibiotics were significantly more likely to sustain urinary tract infection (P=0.03) a postoperative diarrhea (P = 0.02), increased risk of Clostridium difficile infection (P =0.01) with higher rates of both readmission (P= 0.08) and reoperation (P = 0.07) with a significantly longer hospital stay (2.6 vs 1.4 days, P = 0.001). The use of postoperative antibiotic treatment for nonperforated appendicitis did not reduce the infectious complications while increasing postoperative morbidity and increase the length of hospital stay.

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Post-operative antibiotic use in nonperforated appendicitis

Cited by 34 publications

References 7 publications

Risk Factors for Postoperative Intra-Abdominal Abscess after Laparoscopic Appendectomy: Analysis for Consecutive 1,817 Experiences

Risk Factors for Postoperative Intra-Abdominal Abscess after Laparoscopic Appendectomy: Analysis for Consecutive 1,817 Experiences

Metronidazole in Acute Non-perforated Appendicitis

Postoperative Use of Antibiotics in Adults with Non-perforated Appendicitis Subjected to Open Appendectomy

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