Post‐natal development of electrophysiological properties of rat cerebral cortical pyramidal neurones.

McCormick, David A.; Prince, David A.

doi:10.1113/jphysiol.1987.sp016851

Cited by 294 publications

(218 citation statements)

References 61 publications

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“…Consistent with our findings for Kv-mediated currents, the most dramatic changes in AP parameters occur between weeks 1 and 3, approaching adult values by weeks 3-5 (Lorenzon and Foehring 1993;McCormick and Prince 1987;Zhang 2004). Because of its relatively hyperpolarized activation range and fast kinetics (Foehring and Surmeier 1993;Yuan et al 2005), the maturation of A-type current would be expected to lead to more rapid spike repolarization and narrower spikes.…”

Section: Development Of Excitability and Firing Patternssupporting

confidence: 75%

“…Repetitive firing behavior also changes with age (Christophe et al 2005;Kasper et al 1994b;Lorenzon and Foehring 1993;Maravall et al 2004b;McCormick and Prince 1987;Oswald and Reyes 2008). The greatest changes occur between weeks 1 and 3 Lorenzon and Foehring 1993;Locke and Nerbonne 1997a;Maravall et al 2004b;Metherate and Aramakis 1999).…”

Section: Development Of Excitability and Firing Patternsmentioning

confidence: 99%

“…With postnatal age, there is increased ability to spike, decreased AP threshold, increased AP amplitude, and decreased spike width Christophe et al 2005;Kasper et al 1994b;Kriegstein et al 1987;Lorenzon and Foehring 1993;Maravall et al 2004b;McCormick and Prince 1987;Metherate and Aramakis 1999;Oswald and Reyes 2008). Spontaneous firing also increases with development .…”

Section: Development Of Excitability and Firing Patternsmentioning

confidence: 99%

“…Neocortical pyramidal cells are generated prenatally in an "inside-out" laminar pattern (Caviness 1982;Caviness et al 2009;Takahashi et al 1994), and pyramidal cell morphology and physiology mature after birth Beique et al 2004;Blue and Parnevalas 1983;Christophe et al 2005;Kasper et al 1994aKasper et al , 1994bKriegstein et al 1987;Kristt 1978;Lorenzon and Foehring 1993;Maravall et al 2004aMaravall et al , 2004bMcCormick and Prince 1987;Metherate and Aramkis 1999;Miller 1981;Miller and Peters 1981;Oswald and Reyes 2008;Wise and Jones 1976). Cortical circuits are tuned postnatally.…”

mentioning

confidence: 99%

“…Pyramidal cell resting membrane potential (RMP) becomes more hyperpolarized with postnatal development and input resistance and membrane time constant decrease Beique et al 2004;Christophe et al 2005;Kasper et al 1994aKasper et al , 1994bLorenzon and Foehring 1993;Maravall et al 2004a;McCormick and Prince 1987;Metherate and Aramkis 1999;Oswald and Reyes 2008;Tyzio et al 2003). Repetitive firing behavior also changes with age Christophe et al 2005;Kasper et al 1994aKasper et al , 1994bLorenzon and Foehring 1993;Maravall et al 2004aMaravall et al , 2004bMcCormick and Prince 1987;Metherate and Aramkis 1999;Oswald and Reyes 2008;van Brederode et al 2000;Zhang 2004). In mature pyramidal neurons, voltage-gated K ϩ channels contribute to the filtering and integration of synaptic inputs, as well as shaping firing rates and pattern (Guan et al 2007a;Higgs and Spain 2009;Schwindt et al 1988).…”

mentioning

confidence: 99%

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Postnatal development of A-type and Kv1- and Kv2-mediated potassium channel currents in neocortical pyramidal neurons

Guan

Horton

Armstrong

et al. 2011

Journal of Neurophysiology

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Guan D, Horton LR, Armstrong WE, Foehring RC. Postnatal development of A-type and Kv1-and Kv2-mediated potassium channel currents in neocortical pyramidal neurons. J Neurophysiol 105: 2976-2988, 2011. First published March 30, 2011 doi:10.1152/jn.00758.2010.-Potassium channels regulate numerous aspects of neuronal excitability, and several voltage-gated K ϩ channel subunits have been identified in pyramidal neurons of rat neocortex. Previous studies have either considered the development of outward current as a whole or divided currents into transient, A-type and persistent, delayed rectifier components but did not differentiate between current components defined by ␣-subunit type. To facilitate comparisons of studies reporting K ϩ currents from animals of different ages and to understand the functional roles of specific current components, we characterized the postnatal development of identified Kv channel-mediated currents in pyramidal neurons from layers II/III from rat somatosensory cortex. Both the persistent/slowly inactivating and transient components of the total K ϩ current increased in density with postnatal age. We used specific pharmacological agents to test the relative contributions of putative Kv1-and Kv2-mediated currents (100 nM ␣-dendrotoxin and 600 nM stromatoxin, respectively). A combination of voltage protocol, pharmacology, and curve fitting was used to isolate the rapidly inactivating A-type current. We found that the density of all identified current components increased with postnatal age, approaching a plateau at 3-5 wk. We found no significant changes in the relative proportions or kinetics of any component between postnatal weeks 1 and 5, except that the activation time constant for A-type current was longer at 1 wk. The putative Kv2-mediated component was the largest at all ages. Immunocytochemistry indicated that protein expression for Kv4.2, Kv4.3, Kv1.4, and Kv2.1 increased between 1 wk and 4 -5 wk of age. Kv channel; somatosensory cortex; voltage clamp; A current; delayed rectifier AT BIRTH, the rodent somatosensory system is immature, and somatosensory cortex undergoes dramatic changes over the first postnatal month. Neocortical pyramidal cells are generated prenatally in an "inside-out" laminar pattern (Caviness 1982; Caviness et al.

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Section: Development Of Excitability and Firing Patternssupporting

confidence: 75%

Section: Development Of Excitability and Firing Patternsmentioning

confidence: 99%

Section: Development Of Excitability and Firing Patternsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Postnatal development of A-type and Kv1- and Kv2-mediated potassium channel currents in neocortical pyramidal neurons

Guan

Horton

Armstrong

et al. 2011

Journal of Neurophysiology

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Distributed representation of vibrissa movement in the upper layers of somatosensory cortex revealed with voltage-sensitive dyes

1996

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We have identified large-scale patterns of electrical activity in circuits that occur in response to stimulation of peripheral receptors. Our focus was on primary (S1) vibrissal cortex of anesthetized rat, and we used optical techniques in conjunction with voltage-sensitive dyes to measure depolarization of the upper layers of cortex. Displacement of one vibrissa produced a field of activity that extends over very many cortical columns in S1. There are multiple, focal maxima within this field. A global maximum is located near the center of the field of activity, and, as determined electrically and histologically, this site maps to the cortical column appropriate for the deflected vibrissa. The amplitude of this component attains a steady-state value under continuous stimulation. Additional temporal characteristics are revealed by the response to a single displacement; the signal was triphasic and began with a prompt depolarization that was followed by a transient phase of inhibition and a final phase of long-lasting depolarization. The somatotopy of the other, satellite maxima in the field of activity were established through the reconstruction of the fields of activity produced by individual stimulation of other vibrissae. Local maxima for one vibrissa were seen to overlie the global maximum found for stimulation of nearest- and next-nearest-neighbor vibrissae. In contrast to the amplitude of the global maxima, the amplitude associated with the local maxima was not maintained with either continuous or infrequent but repetitive stimulation. Finally, the field of activity induced by alternate deflection of two neighboring vibrissae was suppressed in amplitude in comparison to the summed amplitudes of the signals elicited by deflection of each vibrissa alone. We suggest that these patterns of activity are a manifestation of the dynamic interaction among neighboring cortical columns.

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Intrinsic and synaptic properties of neurons in the vocal-control nucleus lMAN fromin vitro slice preparations of juvenile and adult zebra finches

1998

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A common theme of diverse neural systems is that circuits that are important for initial acquisition of learning do not necessarily serve as a substrate for the long‐term storage of that memory. The neural basis of vocal learning in songbirds provides an example of this phenomenon, since a circuit that is necessary for vocal production during initial stages of vocal development apparently plays no subsequent role in controlling learned vocalizations. This striking functional change suggests the possibility of marked physiological changes in synaptic transmission within this circuit. We therefore examined intrinsic and synaptic properties of neurons in the cortical nucleus lMAN (lateral magnocellular nucleus of the anterior neostriatum), which forms part of this developmentally regulated circuit, in an in vitro preparation of the zebra finch forebrain. Although both functional and morphological characteristics of these neurons change substantially during vocal development, we did not observe widespread, substantive changes in the electrophysiological characteristics of juvenile versus adult lMAN neurons examined in vitro. Overall, both the intrinsic properties and synaptic responses of lMAN neurons were similar in slices from juvenile birds (at ages when lesions of lMAN disrupt vocal production) and in slices from adult birds (when lMAN lesions have no effect on song production). However, one intrinsic property that did vary between juvenile and adult cells was spike duration, which was longer in juvenile cells, suggesting the potential for activation of second‐messenger cascades and/or enhanced synaptic transmission onto target cells of lMAN neurons. The pattern of synaptic response observed in both juvenile and adult cells suggests that lMAN projection neurons receive direct excitatory afferent inputs, as well as disynaptic inhibitory inputs from interneurons within lMAN. Activation of inhibitory interneurons rapidly curtails the excitatory response seen in projection neurons. This inhibition was abolished by bicuculline, indicating that the inhibitory interneurons normally exert their postsynaptic response via GABAA receptors on projection neurons. The inhibitory response could also be blocked by CNQX (6‐cyano‐7‐nitroquinoxaline‐2,3‐dione), suggesting that the activation of inhibitory interneurons within lMAN may be governed primarily by AMPA receptors. © 1998 John Wiley & Sons, Inc. J Neurobiol 37: 642–658, 1998

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Post‐natal development of electrophysiological properties of rat cerebral cortical pyramidal neurones.

Cited by 294 publications

References 61 publications

Postnatal development of A-type and Kv1- and Kv2-mediated potassium channel currents in neocortical pyramidal neurons

Postnatal development of A-type and Kv1- and Kv2-mediated potassium channel currents in neocortical pyramidal neurons

Distributed representation of vibrissa movement in the upper layers of somatosensory cortex revealed with voltage-sensitive dyes

Intrinsic and synaptic properties of neurons in the vocal-control nucleus lMAN fromin vitro slice preparations of juvenile and adult zebra finches

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