Post-mumps acute disseminated encephalomyelitis in an adolescent

Rehani, Varun; Mahto, Subodh Kumar; Sheoran, Ankita; Singh, Akanksha; Verma, Pooja; Kaushik, Kulsaurabh

doi:10.4103/jfmpc.jfmpc_437_19

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…In the patients with meningitis caused by this virus, around 50 % of cases do not noted parotids enlargement [ 3 ], and this percentage can be similar in post-infectious complications, which include ADEM. The latter condition affects the central nervous system and is characterized, in most cases, by an acute encephalopathy and variable multi-focal neurological dysfunction [ 7 , 8 ]. It is considered an autoimmune-based disorder, with most cases being triggered by an infection or vaccine [ 1 , 7 , 8 ].…”

Section: Discussionmentioning

confidence: 99%

“…The latter condition affects the central nervous system and is characterized, in most cases, by an acute encephalopathy and variable multi-focal neurological dysfunction [ 7 , 8 ]. It is considered an autoimmune-based disorder, with most cases being triggered by an infection or vaccine [ 1 , 7 , 8 ]. The diagnosis is based on clinical and imaging changes, with MRI being the most important exam.…”

Section: Discussionmentioning

confidence: 99%

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Acute disseminated encephalomyelitis after mumps infection in a vaccinated patient

Gonçalves

Gomes

Martins

et al. 2021

IDCases

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Mumps is an infectious disease caused by a paramyxovirus. It can involve several organs in the acute stage of the infection, including central nervous system. (Rubin et al., 2015) [ 1 ] Neurological complications in the post-infectious period are also described, one of which is acute disseminated encephalomyelitis (ADEM). (Jonhson et al., 2004) [ 2 ] We present the case of an healthy young man previously vaccinated, who contracted ADEM after mumps.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Acute disseminated encephalomyelitis after mumps infection in a vaccinated patient

Gonçalves

Gomes

Martins

et al. 2021

IDCases

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Influence of Ribavirin on Mumps Virus Population Diversity

Jurković

Slović

Forčić

et al. 2021

Viruses

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Frequent mumps outbreaks in vaccinated populations and the occurrence of neurological complications (e.g., aseptic meningitis or encephalitis) in patients with mumps indicate the need for the development of more efficient vaccines as well as specific antiviral therapies. RNA viruses are genetically highly heterogeneous populations that exist on the edge of an error threshold, such that additional increases in mutational burden can lead to extinction of the virus population. Deliberate modulation of their natural mutation rate is being exploited as an antiviral strategy and a possibility for rational vaccine design. The aim of this study was to examine the ability of ribavirin, a broad-spectrum antiviral agent, to introduce mutations in the mumps virus (MuV) genome and to investigate if resistance develops during long-term in vitro exposure to ribavirin. An increase in MuV population heterogeneity in the presence of ribavirin has been observed after one passage in cell culture, as well as a bias toward C-to-U and G-to-A transitions, which have previously been defined as ribavirin-related. At higher ribavirin concentration, MuV loses its infectivity during serial passaging and does not recover. At low ribavirin concentration, serial passaging leads to a more significant increase in population diversity and a stronger bias towards ribavirin-related transitions, independently of viral strain or cell culture. In these conditions, the virus retains its initial growth capacity, without development of resistance at a whole-virus population level.

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Post-mumps acute disseminated encephalomyelitis in an adolescent

Cited by 2 publications

References 8 publications

Acute disseminated encephalomyelitis after mumps infection in a vaccinated patient

Acute disseminated encephalomyelitis after mumps infection in a vaccinated patient

Influence of Ribavirin on Mumps Virus Population Diversity

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