Post-mortem MRI-based volumetry of the hippocampus in forensic cases of decedents with severe mental illness

Busch, Johannes Rødbro; Lundemose, Sissel Banner; Lynnerup, Niels; Jacobsen, Christina; Jørgensen, Martin Balslev; Banner, Jytte

doi:10.1007/s12024-019-00101-w

Cited by 5 publications

(3 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, its use is limited due to cost and time constraints, limited accessibility, technical complexity and challenges associated with postmortem changes which influences image quality [35,36,[38][39][40][41]. Similar to PMCT, 3D models can be created from PMMR scans, and, e.g., organ volume [42] and bone thickness [43] can be calculated.…”

Section: Three-dimensional Documentation Of the Body: Pmct Pmmr Surfa...mentioning

confidence: 99%

A Virtual, 3D Multimodal Approach to Victim and Crime Scene Reconstruction

Villa,

Lynnerup,

Jacobsen

2023

Diagnostics

View full text Add to dashboard Cite

In the last two decades, forensic pathology and crime scene investigations have seen a rapid increase in examination tools due to the implementation of several imaging techniques, e.g., CT and MR scanning, surface scanning and photogrammetry. These tools encompass relatively simple visualization tools to powerful instruments for performing virtual 3D crime scene reconstructions. A multi-modality and multiscale approach to a crime scene, where 3D models of victims and the crime scene are combined, offers several advantages. A permanent documentation of all evidence in a single 3D environment can be used during the investigation phases (e.g., for testing hypotheses) or during the court procedures (e.g., to visualize the scene and the victim in a more intuitive manner). Advanced computational approaches to understand what might have happened during a crime can also be applied by, e.g., performing a virtual animation of the victim in the actual context, which can provide important information about possible dynamics during the event. Here, we present an overview of the different techniques and modalities used in forensic pathology in conjunction with crime scene investigations. Based on our experiences, the advantages and challenges of an image-based multi-modality approach will be discussed, including how their use may introduce new visualization modalities in court, e.g., virtual reality (VR) and 3D printing. Finally, considerations about future directions in research will be mentioned.

show abstract

Section: Three-dimensional Documentation Of the Body: Pmct Pmmr Surfa...mentioning

confidence: 99%

A Virtual, 3D Multimodal Approach to Victim and Crime Scene Reconstruction

Villa,

Lynnerup,

Jacobsen

2023

Diagnostics

View full text Add to dashboard Cite

show abstract

“…Therefore, in situ post mortem MRI presents a unique possibility for validating in vivo imaging techniques. However, post mortem quantitative MRI is impaired by the temperature dependence of the MRI parameters, including T 1 , T 2 , T 2 *, mean diffusivity (MD) and fractional anisotropy (FA) [3][4][5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

“…Birkl et al [ 4 ] examined the temperature effect on relaxation parameters of fresh post mortem brain slices by heating the slices and measuring them using a 3 T MRI scanner. Scheurer et al [ 3 ], Zech et al [ 5 ], Tashiro et al [ 6 ], Ruder et al [ 8 ], Busch et al [ 9 ], as well as Flach et al [ 10 ] examined the MRI parameters as a function of the core temperature determined in the rectum with a 1.5 T MRI scanner, while Tofts et al [ 16 ] corrected the MRI parameters based on the diffusion constant in the cerebrospinal fluid of two deceased subjects with enlarged ventricular volumes. Kobayashi et al [ 7 ] revealed the temperature dependence of the MRI parameters based on tissue contrast changes, while Zech et al [ 5 ] investigated the effect of temperature on the relaxation parameters in situ with a 1.5 T MRI scanner by assessing the core temperature in the esophagus.…”

Section: Introductionmentioning

confidence: 99%

Post mortem brain temperature and its influence on quantitative MRI of the brain

Berger

Bauer

Wittig

et al. 2021

Magn Reson Mater Phy

View full text Add to dashboard Cite

Objective MRI temperature sensitivity presents a major issue in in situ post mortem MRI (PMMRI), as the tissue temperatures differ from living persons due to passive cooling of the deceased. This study aims at computing brain temperature effects on the MRI parameters to correct for temperature in PMMRI, laying the foundation for future projects on post mortem validation of in vivo MRI techniques. Materials and methods Brain MRI parameters were assessed in vivo and in situ post mortem using a 3 T MRI scanner. Post mortem brain temperature was measured in situ transethmoidally. The temperature effect was computed by fitting a linear model to the MRI parameters and the corresponding brain temperature. Results Linear positive temperature correlations were observed for T1, T2* and mean diffusivity in all tissue types. A significant negative correlation was observed for T2 in white matter. Fractional anisotropy revealed significant correlations in all gray matter regions except for the thalamus. Discussion The linear models will allow to correct for temperature in post mortem MRI. Comparing in vivo to post mortem conditions, the mean diffusivity, in contrast to T1 and T2, revealed additional effects besides temperature, such as cessation of perfusion and active diffusion.

show abstract