Post-mortem interval estimation using miRNAs of road traffic accident cases: A forensic molecular approach

Singh, Paurabhi; Ali, Wahid; Sandhu, Sangram; Mishra, Sridhar; Singh, U. S.; Singh, Madhulika; Ahmad, M. Kaleem; Kumari, Sangeeta

doi:10.1016/j.scijus.2023.04.011

Cited by 2 publications

(1 citation statement)

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“…miRNAs show distinctive expression patterns in response to various physiological and pathological conditions, making them potential markers as much in forensic diagnostics and medicolegal investigations as in clinical practice. By expanding our knowledge in this area, expression analyses of different miRNAs may lead to the identification of new markers for tissue changes related to aging and/or pathophysiological conditions, thereby strengthening the scope of forensic science research [ 15 , 16 , 17 ]. Indeed, in recent years, data sharing between seemingly distant fields such as forensic science and clinical practice has facilitated the cross-pollination of knowledge, leading to advances in both fields [ 12 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Special Issue “Molecular Biology in Forensic Science: Past, Present and Future”

Sessa,

Salerno

2024

IJMS

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Section: Introductionmentioning

confidence: 99%

Special Issue “Molecular Biology in Forensic Science: Past, Present and Future”

Sessa,

Salerno

2024

IJMS

View full text Add to dashboard Cite

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microRNAs as New Biomolecular Markers to Estimate Time since Death: A Systematic Review

Cianci,

Mondello,

Sapienza

et al. 2024

IJMS

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Estimating the post-mortem interval is still one of the most complex challenges in forensics. In fact, the main tools currently used are burdened by numerous limitations, which sometimes allow the time of death to be placed only within too large time intervals. In recent years, researchers have tried to identify new tools to try to narrow down the interval within which to place the time of death; among these, the analysis of microRNAs seems to be promising. An evidence-based systematic review of the literature has been conducted to evaluate the state of the art of knowledge, focusing on the potential correlation between miRNA degradation and PMI estimation. The research has been performed using the electronic databases PubMed, Scopus, and WOS. The results allowed us to highlight the usefulness of miRNAs both as markers for PMI estimation and for normalization, especially due to their stability. In fact, some miRNAs remain particularly stable for long periods and in different tissues, while others degrade faster. Furthermore, there are numerous factors capable of influencing the behavior of these molecules, among which the type of tissue, the cause of death, and the circadian rhythm appear to be the most relevant. Despite the promising results of the few articles present in the literature, because of the numerous limitations they are burdened by, further research is still necessary to achieve more solid and shareable results.

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Post-mortem interval estimation using miRNAs of road traffic accident cases: A forensic molecular approach

Cited by 2 publications

References 36 publications

Special Issue “Molecular Biology in Forensic Science: Past, Present and Future”

Special Issue “Molecular Biology in Forensic Science: Past, Present and Future”

microRNAs as New Biomolecular Markers to Estimate Time since Death: A Systematic Review

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