Post-manufacture loading of filaments and 3D printed PLA scaffolds with prednisolone and dexamethasone for tissue regeneration applications

Farto-Vaamonde, Xián; Auriemma, Giulia; Aquino, Rita Patrizia; Concheiro, Ángel; Álvarez-Lorenzo, Carmen

doi:10.1016/j.ejpb.2019.05.018

Cited by 60 publications

(59 citation statements)

References 49 publications

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“…The measured drug concentration was decreased to 79% ( w / w ) at 150 °C and 15% ( w / w ) at 250 °C. Moreover, in a study by Farto-Vaamonde et al [ 49 ], prednisolone and dexamethasone were loaded into polylactic acid filaments using the filament soaking approach. Subsequently, the drug-loaded filaments were printed at 220 °C.…”

Section: Resultsmentioning

confidence: 99%

Production of Drug Delivery Systems Using Fused Filament Fabrication: A Systematic Review

Shaqour

Samaro

Verleije³

et al. 2020

Pharmaceutics

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Fused filament fabrication (FFF) 3D printing technology is widely used in many fields. For almost a decade, medical researchers have been exploring the potential use of this technology for improving the healthcare sector. Advances in personalized medicine have been more achievable due to the applicability of producing drug delivery devices, which are explicitly designed based on patients’ needs. For the production of these devices, a filament—which is the feedstock for the FFF 3D printer—consists of a carrier polymer (or polymers) and a loaded active pharmaceutical ingredient (API). This systematic review of the literature investigates the most widely used approaches for producing drug-loaded filaments. It also focusses on several factors, such as the polymeric carrier and the drug, loading capacity and homogeneity, processing conditions, and the intended applications. This review concludes that the filament preparation method has a significant effect on both the drug homogeneity within the polymeric carrier and drug loading efficiency.

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Section: Resultsmentioning

confidence: 99%

Production of Drug Delivery Systems Using Fused Filament Fabrication: A Systematic Review

Shaqour

Samaro

Verleije³

et al. 2020

Pharmaceutics

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“…In addition, defect filling, integration to the surrounding host cartilage, and macroscopic appearance were better than those of the control group (empty defect) ( Figure 3a Finally, FDM-strategies to load drugs in 3D-printed scaffolds were developed as a way of customizing the drug release patterns for regenerative medicine aims [37,38]. One approach consisted of soaking PLA filaments into a drug solution before printing the scaffold, and another consisted of printing the scaffolds and then soaking them in the drug solution [39]. The combination of both methods offers the chance of creating concentration gradients of drugs with distinct release profiles in the same scaffold (dually loaded scaffolds).…”

Section: D-printing By Fused Deposition Modeling (Fdm)mentioning

confidence: 99%

Solvent-Free Approaches for the Processing of Scaffolds in Regenerative Medicine

2020

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The regenerative medicine field is seeking novel strategies for the production of synthetic scaffolds that are able to promote the in vivo regeneration of a fully functional tissue. The choices of the scaffold formulation and the manufacturing method are crucial to determine the rate of success of the graft for the intended tissue regeneration process. On one hand, the incorporation of bioactive compounds such as growth factors and drugs in the scaffolds can efficiently guide and promote the spreading, differentiation, growth, and proliferation of cells as well as alleviate post-surgical complications such as foreign body responses and infections. On the other hand, the manufacturing method will determine the feasible morphological properties of the scaffolds and, in certain cases, it can compromise their biocompatibility. In the case of medicated scaffolds, the manufacturing method has also a key effect in the incorporation yield and retained activity of the loaded bioactive agents. In this work, solvent-free methods for scaffolds production, i.e., technological approaches leading to the processing of the porous material with no use of solvents, are presented as advantageous solutions for the processing of medicated scaffolds in terms of efficiency and versatility. The principles of these solvent-free technologies (melt molding, 3D printing by fused deposition modeling, sintering of solid microspheres, gas foaming, and compressed CO2 and supercritical CO2-assisted foaming), a critical discussion of advantages and limitations, as well as selected examples for regenerative medicine purposes are herein presented.

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“…The use of PLA is limited by its poor thermal stability and easy hydrolysis—it degrades more easily than other aliphatic polyesters. Nevertheless, PLA has found many applications in diverse areas including the packaging industry as a food packaging polymer for short shelf life products, the pharmaceutical industry for controlled drug delivery formulations and for tissue regeneration, and agriculture for better herbicide delivery management without negative effects on crop yield ( Auras, Harte & Selke, 2004 ; Aziz, Haq & Raina, 2020 ; Farto-Vaamonde et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Polylactic acid as a suitable material for 3D printing of protective masks in times of COVID-19 pandemic

Vaňková

Kašparová

Khun

et al. 2020

PeerJ

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A critical lack of personal protective equipment has occurred during the COVID-19 pandemic. Polylactic acid (PLA), a polyester made from renewable natural resources, can be exploited for 3D printing of protective face masks using the Fused Deposition Modelling technique. Since the possible high porosity of this material raised questions regarding its suitability for protection against viruses, we have investigated its microstructure using scanning electron microscopy and aerosol generator and photometer certified as the test system according to the standards EN 143 and EN 149. Moreover, the efficiency of decontaminating PLA surfaces by conventional chemical disinfectants including 96% ethanol, 70% isopropanol, and a commercial disinfectant containing 0.85% sodium hypochlorite has been determined. We confirmed that the structure of PLA protective masks is compact and can be considered a sufficient barrier protection against particles of a size corresponding to microorganisms including viruses. Complete decontamination of PLA surfaces from externally applied Staphylococcus epidermidis, Escherichia coli, Candida albicans and SARS-CoV-2 was achieved using all disinfectants tested, and human adenovirus was completely inactivated by sodium hypochlorite-containing disinfectant. Natural contamination of PLA masks worn by test persons was decontaminated easily and efficiently by ethanol. No disinfectant caused major changes to the PLA surface properties, and the pore size did not change despite severe mechanical damage of the surface. Therefore, PLA may be regarded as a suitable material for 3D printing of protective masks during the current or future pandemic crises.

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Post-manufacture loading of filaments and 3D printed PLA scaffolds with prednisolone and dexamethasone for tissue regeneration applications

Cited by 60 publications

References 49 publications

Production of Drug Delivery Systems Using Fused Filament Fabrication: A Systematic Review

Production of Drug Delivery Systems Using Fused Filament Fabrication: A Systematic Review

Solvent-Free Approaches for the Processing of Scaffolds in Regenerative Medicine

Polylactic acid as a suitable material for 3D printing of protective masks in times of COVID-19 pandemic

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