Post–Liver Transplantation Management

Hunt, Douglas; Saab, Sammy

doi:10.1016/b978-1-4377-0881-3.00049-8

Cited by 2 publications

(1 citation statement)

References 169 publications

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“…Chronic rejection is a primary driver for reduced graft function over time ( 4 ), and patients that experience rejection may require supplementary therapeutic interventions such as re-transplantation. For example, over the last 5-10 years, it is estimated that the incidence of chronic rejection in liver transplant recipients is 2-5%, accounting for approximately 15-20% of graft losses and nearly 14% of all liver re-transplantations ( 5 , 6 ). This places a huge burden not only on the individual patient, but also on the health care system as a whole and the ever-growing waitlist for available organs.…”

Section: Introductionmentioning

confidence: 99%

Foxp3+ regulatory T cell therapy for tolerance in autoimmunity and solid organ transplantation

et al. 2022

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Regulatory T cells (Tregs) are critical for tolerance in humans. The exact mechanisms by which the loss of peripheral tolerance leads to the development of autoimmunity and the specific role Tregs play in allograft tolerance are not fully understood; however, this population of T cells presents a unique opportunity in the development of targeted therapeutics. In this review, we discuss the potential roles of Foxp3+ Tregs in the development of tolerance in transplantation and autoimmunity, and the available data regarding their use as a treatment modality.

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Section: Introductionmentioning

confidence: 99%