Post liver transplant tuberculosis

Rodrigues, Luís Vaz; Gandara, Judit; Pires, João Valter; Duarte, Raquel; Calvário, Fernando; Domínguez, Miguel; Carvalho, Aurora; Seca, R.

doi:10.1136/bcr.05.2009.1847

Cited by 3 publications

(1 citation statement)

References 4 publications

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“…In none of them INH hepatotoxicity has been reported despite of at least 6 months of therapy (6-8). It is very important to monitor the patients with liver transplant on both anti TB and immunosuppressive drugs, in order to prevent graft rejection and maintain an effective anti TB therapy, because of high mortality of untreated TB in a transplant recipient (11). As a conclusion high degree of suspicion is necessary for diagnosis of post-liver hepatic transplant TB and should be considered in the patients with fever and night sweat as well as abnormal LFT.…”

Section: Discussionmentioning

confidence: 99%

Isolated Tuberculosis of Transplanted Liver, A Case Report and Review of the Literature

et al. 2013

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IntroductionRecipients of liver transplantation are prone to different types of infections such as tuberculosis (TB).Case PresentationHerein we report a 59-year-old man with liver transplantation due to HBV cirrhosis who developed isolated hepatic TB, 18 months after OLT (orthotropic liver transplantation). He has been successfully treated with anti-TB regimen and now after 12 months he is completely symptom-free.ConclusionsOrgan transplantation and treatment of transplanted patients with immunosuppressive drugs would prone them to various unusual infections. One of these is unusual primary involvement of liver by tuberculosis which has been extremely rare in the previous reports.

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Section: Discussionmentioning

confidence: 99%

Isolated Tuberculosis of Transplanted Liver, A Case Report and Review of the Literature

et al. 2013

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Modelling heterogeneity in host susceptibility to tuberculosis and its effect on public health interventions

Wangari¹,

Trauer

Stone

2018

PLoS ONE

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A tuberculosis (TB) model that accounts for heterogeneity in host susceptibility to tuberculosis is proposed, with the aim of investigating the implications this may have for the effectiveness of public health interventions. The model examines the possibility that recovered individuals treated from active TB and individuals treated with preventive therapy acquire different levels of immunity. This contrasts with recent studies that assume the two cohorts acquire the same level of immunity, and therefore both groups are reinfected at the same rate. The analysis presented here examines the impact of this assumption when designing intervention strategies. Comparison of reinfection rates between cohorts treated with preventive therapy and recovered individuals who were previously treated for active TB provides important epidemiological insights. It is found that the reinfection rate of the cohort treated with preventive therapy is the one that plays the key role in qualitative changes in TB dynamics. By contrast, the reinfection rate of recovered individuals (previously treated from active TB) plays a minor role. Moreover, the study shows that preventive treatment of individuals during early latency is always beneficial regardless of the level of susceptibility to reinfection. Further, if patients have greater immunity following treatment for late latent infection, then treatment is again beneficial. However, if susceptibility increases following treatment for late latent infection, the effect of treatment depends on the epidemiological setting. That is: (i) in (very) low burden settings, the effect on reactivation predominates and the burden declines with treatment; (ii) in moderate to high burden settings the effect of reinfection predominates and burden increases with treatment. The effect is most dominant between the two reinfection thresholds, RT2 and RT1, respectively associated with individuals being treated with preventive therapy and individuals with untreated late latent TB infection.

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Post Liver Transplant Granulomatous Hepatitis: Hepatic Tuberculosis Diagnosed By Synovial Aspirate of the Knee.

Bokhari¹,

Hashim²,

Haque³

et al. 2012

IJGE

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Post liver transplant tuberculosis

Cited by 3 publications

References 4 publications

Isolated Tuberculosis of Transplanted Liver, A Case Report and Review of the Literature

Isolated Tuberculosis of Transplanted Liver, A Case Report and Review of the Literature

Modelling heterogeneity in host susceptibility to tuberculosis and its effect on public health interventions

Post Liver Transplant Granulomatous Hepatitis: Hepatic Tuberculosis Diagnosed By Synovial Aspirate of the Knee.

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