‘Post-LA space index’ as a potential novel marker for the prenatal diagnosis of isolated total anomalous pulmonary venous connection

Kawazu, Yukiko; Inamura, Noboru; Shiono, Nobuko; Kanagawa, N.; Narita, Jun; Hamamichi, Yuji; Kayatani, Futoshi

doi:10.1002/uog.13357

Cited by 30 publications

(82 citation statements)

References 16 publications

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“…In normal fetuses, the space posterior to the left atrium (LA) is usually narrow, with the descending aorta and being close to each other . We previously reported that this space is wider in fetuses with total anomalous pulmonary venous connection (TAPVC), a rare form of severe congenital heart disease that requires emergency neonatal surgery associated with a high mortality . It is still difficult to detect TAPVC prenatally because the four‐chamber view looks normal .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the post‐LA space index in the normal fetus

et al. 2019

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Objective We previously reported the post‐LA space index (PLAS index), which is calculated as left atrial‐descending aorta distance (LD) divided by the diameter of descending aorta (DA), could be useful for prenatal diagnosis of total anomalous pulmonary venous connection (TAPVC). In this study, we evaluated PLAS index in normal fetuses to assess its usefulness. Methods In 304 normal fetuses, LD and DA were retrospectively measured, and the PLAS index was calculated. In 206 fetuses with data on the biparietal diameter (BPD) and femoral length (FL), the relationship between the PLAS index and them was investigated. We also calculated the PLAS index in 13 TAPVC fetuses. Results Mean LD was 3.0+/−0.94 mm, mean DA was 4.8+/−0.87 mm, and the mean PLAS index was 0.62+/−0.19. DA and LD were correlated with gestational age (R = 0.52, 0.25), while the PLAS index showed little variation with gestational age (R < 0.2). BPD and FL were correlated with DA (R = 0.4, 0.42) but not with LD or the PLAS index (both R < 0.2). In the TAPVC fetuses, both LD and the PLAS index were significantly higher than in normal fetuses. Conclusion In normal fetuses, the PLAS index was independent of gestational age and fetal physique and may be useful for raising the suspicion of congenital heart disease, including TAPVC.

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Section: Introductionmentioning

confidence: 99%

Evaluation of the post‐LA space index in the normal fetus

et al. 2019

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“…Forest plot of rate of favorable outcome (alive operated) for fetuses with total anomalous pulmonary venous connection, reported in 10 primary studies and five case reports. Only first author of each study is given.…”

Section: Resultsmentioning

confidence: 99%

“…Forest plots for studies on cases of total anomalous pulmonary venous connection, of rate of prenatally detected ventricular disproportion reported in eight primary studies and five case reports (a), increased area behind left atrium reported in 10 primary studies and four case reports (b) and vertical vein reported in 10 primary studies and three case reports (c). Only first author of each study is given.…”

Section: Resultsmentioning

confidence: 99%

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Prenatal diagnosis of total and partial anomalous pulmonary venous connection: multicenter cohort study and meta‐analysis

Paladini

Pistorio

et al. 2018

Ultrasound in Obstet & Gyne

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TAPVC can be associated with other cardiac and extracardiac anomalies in a significant percentage of cases. Leading sonographic signs are ventricular disproportion, increased area behind the left atrium and the finding of a vertical vein. Color/power Doppler is the key mode for diagnosis of TAPVC. Obstructed venous return can be expected in roughly one-third of cases of TAPVC and outcome is favorable in less than half of cases. Data for SS and PAPVC are too few to synthesize. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd.

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“…Y. et al described a novel and efficient ultrasound marker of TAPVC, the "post-LA space index". It has been proved, that if the ratio of the descending aortaleft atrium distance to the diameter of descending aorta is higher than 1.27, the diagnosis of TAPVC is confirmed with a sensitivity of 100% and specificity of 99% 16 . Doppler echocardiography may also be useful in diagnosis of TAPVC.…”

Section: Discussionmentioning

confidence: 99%

Prenatal Diagnosis of TAPVC on Monday, Delivery of Tuesday and Cardiac Surgery at Wednesday - A Model of Perinatal Care in 3rd Trimester in Case of Fetal/Neonatal Critical Heart Defect in Tertiary Center.

Respondek-Liberska

Sokołowski

Słodki

et al. 2016

Prenatal Cardiology

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Total anomalous pulmonary venous connection (TAPVC) is a congenital heart defect (CHD), in which all pulmonary veins connect to the systemic veins or to the right atrium/coronary sinus instead of the left atrium. We present a case report of fetus with prenatally diagnosed isolated infracardiac type of TAPVC in 38th week of gestation. In fetal echocardiographic examination performed in the Department of Prenatal Cardiology, the fetus presented lack of visible pulmonary veins connection to left atrium, abnormal venous confluence behind left atrium, additional vein leading from abdominal cavity to mediastinum and abnormal smooth Doppler blood flow in pulmonary confluence. The accurate prenatal diagnosis allowed to deliver the neonate at term, in tertiary center one day after diagnosis, and to perform surgical reposition of pulmonary veins the following day. The neonate was referred home in a good condition after 28 days of hospitalization. This case is a good example of the value of the 3rd trimester echocardiography. Key words: total anomalous pulmonary venous return, prenatal diagnosis, fetal echocardiographyCorresponding author: l.sokolowski90@gmail.com Submitted: 2016Submitted: -06-30, accepted: 2016 INTRODUCTIONTotal anomalous pulmonary venous connection (TAPVC) is a congenital heart defect (CHD), in which all pulmonary veins connect to the systemic veins or to the right atrium/ coronary sinus instead of the left atrium. TAPVC is a relatively rare pathology.

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‘Post-LA space index’ as a potential novel marker for the prenatal diagnosis of isolated total anomalous pulmonary venous connection

Abstract: Objectives To review the fetal echocardiograms of patients with total anomalous pulmonary venous connection (TAPVC) in order to

Cited by 30 publications

References 16 publications

Evaluation of the post‐LA space index in the normal fetus

Evaluation of the post‐LA space index in the normal fetus

Prenatal diagnosis of total and partial anomalous pulmonary venous connection: multicenter cohort study and meta‐analysis

Prenatal Diagnosis of TAPVC on Monday, Delivery of Tuesday and Cardiac Surgery at Wednesday - A Model of Perinatal Care in 3rd Trimester in Case of Fetal/Neonatal Critical Heart Defect in Tertiary Center.

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