Post-kala-azar dermal leishmaniasis due to Leishmania infantum in an HIV-negative patient treated with miltefosine

Abstract

Highlight Post-kala azar dermal leishmaniasis due to Leishmania infantum in an HIV-negative patient is very infrequent and this case highlights how it can be associated to other types of immunosuppression. Moreover, this case reports an effective therapeutic option with miltefosine which can be very useful due to the scarce experience reported.

Molecular Diagnosis of Leishmaniasis in Spain: Development and Validation of Ready-To-Use Gel-Form Nested and Real-Time PCRs To Detect Leishmania spp.

“…In recent years, the spectacular outbreak of Fuenlabrada (Madrid), with more than 700 cases so far, has shown the impact of urbanization and the role of wild animals (hares) as reservoirs increasing the risk of transmission of L. infantum when they are surrounding urban areas ( 8 – 10 ). As L. infantum is the only species of Leishmania circulating in Spain, it is responsible for autochthonous leishmaniasis, including CL and VL, while PKDL is rare and is mostly described in immunocompromised patients due to HIV ( 11 ). In contrast, imported leishmaniasis is caused by different species depending on the geographical region where it was acquired, not observing a higher frequency of any specific species ( 12 ).…”